245 Development and application of physiologically based pharmacokinetic – pharmacodynamic (PBPK-PD) model for dose optimization of TAK-102: GPC3 targeted CAR-T armored with IL-7 a... oleh Yasutoshi Kuboki, Takako Eguchi Nakajima, Takafumi Koyama, Eriko Sumi, Kotaro Suzuki, Agnish Dey, Hideaki Kagehara, Petar Pop-Damkov, Eiki Maeda, Takenori Akaike, Kondala Atkuri, Masashi Ochi, Ganesh M Mugundu, Aman Singh