Hasil Pencarian - Stephen C Pak

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  1. 1
    Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

    Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis oleh Qingya Shi, Fen Pei, Gary A. Silverman, Stephen C. Pak, David H. Perlmutter, Bing Liu, Ivet Bahar

    Diterbitkan 2020-04-01
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  2. 2
    A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.

    A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans. oleh Mark T Miedel, Nathan J Graf, Kate E Stephen, Olivia S Long, Stephen C Pak, David H Perlmutter, Gary A Silverman, Cliff J Luke

    Diterbitkan 2012-01-01
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  3. 3
    Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency.

    Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency. oleh Erin E Cummings, Linda P O'Reilly, Dale E King, Richard M Silverman, Mark T Miedel, Cliff J Luke, David H Perlmutter, Gary A Silverman, Stephen C Pak

    Diterbitkan 2015-01-01
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  4. 4
    Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency.

    Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency. oleh Jie Li, Stephen C Pak, Linda P O'Reilly, Joshua A Benson, Yan Wang, Tunda Hidvegi, Pamela Hale, Christine Dippold, Michael Ewing, Gary A Silverman, David H Perlmutter

    Diterbitkan 2014-01-01
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  5. 5
    An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z.

    An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z. oleh Yan Wang, Murat C Cobanoglu, Jie Li, Tunda Hidvegi, Pamela Hale, Michael Ewing, Andrew S Chu, Zhenwei Gong, Radhika Muzumdar, Stephen C Pak, Gary A Silverman, Ivet Bahar, David H Perlmutter

    Diterbitkan 2019-01-01
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  6. 6
    Model organisms contribute to diagnosis and discovery in the undiagnosed diseases network: current state and a future vision

    Model organisms contribute to diagnosis and discovery in the undiagnosed diseases network: current state and a future vision oleh Dustin Baldridge, Michael F. Wangler, Angela N. Bowman, Shinya Yamamoto, Undiagnosed Diseases Network, Tim Schedl, Stephen C. Pak, John H. Postlethwait, Jimann Shin, Lilianna Solnica-Krezel, Hugo J. Bellen, Monte Westerfield

    Diterbitkan 2021-05-01
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  7. 7
    A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during C. elegans post-embryonic development and identifies compounds that modulate autophagy

    A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during C. elegans post-embryonic development and identifies compounds that modula... oleh Zachary D. Dawson, Hemalatha Sundaramoorthi, Suk Regmi, Bo Zhang, Stephanie Morrison, Sara M. Fielder, Jessie R. Zhang, Hieu Hoang, David H. Perlmutter, Cliff J. Luke, Gary A. Silverman, Stephen C. Pak

    Diterbitkan 2024-12-01
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  8. 8
    Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z.

    Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z. oleh Sager J Gosai, Joon Hyeok Kwak, Cliff J Luke, Olivia S Long, Dale E King, Kevin J Kovatch, Paul A Johnston, Tong Ying Shun, John S Lazo, David H Perlmutter, Gary A Silverman, Stephen C Pak

    Diterbitkan 2010-11-01
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  9. 9
    SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation

    SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation oleh Songyan Wang, Cliff J. Luke, Stephen C. Pak, Victoria Shi, Liyun Chen, Jonathan Moore, Arlise P. Andress, Kay Jayachandran, Jin Zhang, Yi Huang, Marina Platik, Anthony A. Apicelli, Julie K. Schwarz, Perry W. Grigsby, Gary A. Silverman, Stephanie Markovina

    Diterbitkan 2022-01-01
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  10. 10
    Multiple Genes Core to ERAD, Macroautophagy and Lysosomal Degradation Pathways Participate in the Proteostasis Response in α1-Antitrypsin DeficiencySummary

    Multiple Genes Core to ERAD, Macroautophagy and Lysosomal Degradation Pathways Participate in the Proteostasis Response in α1-Antitrypsin DeficiencySummary oleh Jie Li, Francesca Moretti, Tunda Hidvegi, Sanja Sviben, James A.J. Fitzpatrick, Hemalatha Sundaramoorthi, Stephen C. Pak, Gary A. Silverman, Britta Knapp, Ireos Filipuzzi, John Alford, John Reece-Hoyes, Florian Nigsch, Leon O. Murphy, Beat Nyfeler, David H. Perlmutter

    Diterbitkan 2024-01-01
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  11. 11
    CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans.

    CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans. oleh Brian J Thomas, Ira E Wight, Wendy Y Y Chou, Marco Moreno, Zachary Dawson, Arielle Homayouni, Huiyan Huang, Hyori Kim, Hanna Jia, Justin R Buland, Jennifer A Wambach, F Sessions Cole, Stephen C Pak, Gary A Silverman, Cliff J Luke

    Diterbitkan 2019-01-01
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  12. 12
    Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

    Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins oleh Cliff J. Luke, Stephanie Markovina, Misty Good, Ira E. Wight, Brian J. Thomas, John M. Linneman, Wyatt E. Lanik, Olga Koroleva, Maggie R. Coffman, Mark T. Miedel, Qingqing Gong, Arlise Andress, Marlene Campos Guerrero, Songyan Wang, LiYun Chen, Wandy L. Beatty, Kelsey N. Hausmann, Frances V. White, James A. J. Fitzpatrick, Anthony Orvedahl, Stephen C. Pak, Gary A. Silverman

    Diterbitkan 2022-01-01
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  13. 13
    Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling.

    Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling. oleh Ronit Marom, Bo Zhang, Megan E Washington, I-Wen Song, Lindsay C Burrage, Vittoria C Rossi, Ava S Berrier, Anika Lindsey, Jacob Lesinski, Michael L Nonet, Jian Chen, Dustin Baldridge, Gary A Silverman, V Reid Sutton, Jill A Rosenfeld, Alyssa A Tran, M John Hicks, David R Murdock, Hongzheng Dai, MaryAnn Weis, Shalini N Jhangiani, Donna M Muzny, Richard A Gibbs, Richard Caswell, Carrie Pottinger, Deirdre Cilliers, Karen Stals, Undiagnosed Diseases Network, David Eyre, Deborah Krakow, Tim Schedl, Stephen C Pak, Brendan H Lee

    Diterbitkan 2023-11-01
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  14. 14
    Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors

    Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors oleh Jana Willim, Daniel Woike, Daniel Greene, Sarada Das, Kevin Pfeifer, Weimin Yuan, Anika Lindsey, Omar Itani, Amber L. Böhme, Debora Tibbe, Hans-Hinrich Hönck, Fatemeh Hassani Nia, Undiagnosed Diseases Network, Michael Zech, Theresa Brunet, Laurence Faivre, Arthur Sorlin, Antonio Vitobello, Thomas Smol, Cindy Colson, Kristin Baranano, Krista Schatz, Allan Bayat, Kelly Schoch, Rebecca Spillmann, Erica E. Davis, Erin Conboy, Francesco Vetrini, Konrad Platzer, Sonja Neuser, Janina Gburek-Augustat, Alexandra Noel Grace, Bailey Mitchell, Alexander Stegmann, Margje Sinnema, Naomi Meeks, Carol Saunders, Maxime Cadieux-Dion, Juliane Hoyer, Julien Van-Gils, Jean-Madeleine de Sainte-Agathe, Michelle L. Thompson, E. Martina Bebin, Monika Weisz-Hubshman, Anne-Claude Tabet, Alain Verloes, Jonathan Levy, Xenia Latypova, Sönke Harder, Gary A. Silverman, Stephen C. Pak, Tim Schedl, Kathleen Freson, Andrew Mumford, Ernest Turro, Christian Schlein, Vandana Shashi, Hans-Jürgen Kreienkamp

    Diterbitkan 2024-09-01
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