Editorial: Autophagy: From Big Data to Physiological Significance by Sovan Sarkar, Maria I. Vaccaro, Ioannis P. Nezis

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Selective Autophagy and Xenophagy in Infection and Disease by Vartika Sharma, Surbhi Verma, Elena Seranova, Sovan Sarkar, Dhiraj Kumar

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Biomedical Implications of Autophagy in Macromolecule Storage Disorders by Adina Maria Palhegyi, Elena Seranova, Simona Dimova, Sheabul Hoque, Sovan Sarkar

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Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. by Shuqiu Zheng, Erin B D Clabough, Sovan Sarkar, Marie Futter, David C Rubinsztein, Scott O Zeitlin

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Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast. by Thomas A Ward, Zuzana Dudášová, Sovan Sarkar, Mangesh R Bhide, Danuša Vlasáková, Miroslav Chovanec, Peter J McHugh

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Analysis of autophagy deficiency and cytotoxicity in autophagy-deficient human embryonic stem cell-derived neurons by Miriam E. Korsgen, Congxin Sun, Elena Seranova, Malgorzata Zatyka, Dewi Astuti, Tetsushi Kataura, Timothy Barrett, Viktor I. Korolchuk, Sovan Sarkar

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Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells by Dorothea Maetzel, Sovan Sarkar, Haoyi Wang, Lina Abi-Mosleh, Ping Xu, Albert W. Cheng, Qing Gao, Maisam Mitalipova, Rudolf Jaenisch

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Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells by John P. Cassady, Ana C. D’Alessio, Sovan Sarkar, Vardhan S. Dani, Zi Peng Fan, Kibibi Ganz, Reinhard Roessler, Mriganka Sur, Richard A. Young, Rudolf Jaenisch

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Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human Diseases by Prashanta Kumar Panda, Alexandra Fahrner, Somya Vats, Somya Vats, Elena Seranova, Vartika Sharma, Miruna Chipara, Priyal Desai, Jorge Torresi, Jorge Torresi, Tatiana Rosenstock, Tatiana Rosenstock, Dhiraj Kumar, Sovan Sarkar

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SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability by Sophia X. Pfister, Sara Ahrabi, Lykourgos-Panagiotis Zalmas, Sovan Sarkar, François Aymard, Csanád Z. Bachrati, Thomas Helleday, Gaëlle Legube, Nicholas B. La Thangue, Andrew C.G. Porter, Timothy C. Humphrey

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A UV-Induced Genetic Network Links the RSC Complex to Nucleotide Excision Repair and Shows Dose-Dependent Rewiring by Rohith Srivas, Thomas Costelloe, Anne-Ruxandra Carvunis, Sovan Sarkar, Erik Malta, Su Ming Sun, Marijke Pool, Katherine Licon, Tibor van Welsem, Fred van Leeuwen, Peter J. McHugh, Haico van Attikum, Trey Ideker

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Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity by Bernadette Carroll, Dorothea Maetzel, Oliver DK Maddocks, Gisela Otten, Matthew Ratcliff, Graham R Smith, Elaine A Dunlop, João F Passos, Owen R Davies, Rudolf Jaenisch, Andrew R Tee, Sovan Sarkar, Viktor I Korolchuk

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Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity by Bernadette Carroll, Dorothea Maetzel, Oliver DK Maddocks, Gisela Otten, Matthew Ratcliff, Graham R Smith, Elaine A Dunlop, João F Passos, Owen Richard Davies, Rudolf Jaenisch, Andrew R Tee, Sovan Sarkar, Viktor I Korolchuk

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Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease by Sovan Sarkar, Bernadette Carroll, Yosef Buganim, Dorothea Maetzel, Alex H.M. Ng, John P. Cassady, Malkiel A. Cohen, Souvik Chakraborty, Haoyi Wang, Eric Spooner, Hidde Ploegh, Joerg Gsponer, Viktor I. Korolchuk, Rudolf Jaenisch

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Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle by Zhe Song, Daniel R. Moore, Nathan Hodson, Carl Ward, Jessica R. Dent, Mary F. O’Leary, Andrew M. Shaw, D. Lee Hamilton, Sovan Sarkar, Yann-Gaël Gangloff, Troy A. Hornberger, Lawrence L. Spriet, George J. Heigenhauser, Andrew Philp

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Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models by Tetsushi Kataura, Lucia Sedlackova, Congxin Sun, Gamze Kocak, Niall Wilson, Peter Banks, Faisal Hayat, Sergey Trushin, Eugenia Trushina, Oliver D. K. Maddocks, John E. Oblong, Satomi Miwa, Masaya Imoto, Shinji Saiki, Daniel Erskine, Marie E. Migaud, Sovan Sarkar, Viktor I. Korolchuk

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The glutamate/aspartate transporter EAAT1 is crucial for T-cell acute lymphoblastic leukemia proliferation and survival by Vesna S. Stanulović, Shorog Al Omair, Michelle A.C. Reed, Jennie Roberts, Sandeep Potluri, Taylor Fulton-Ward, Nancy Gudgeon, Emma L. Bishop, Juliette Roels, Tracey A. Perry, Sovan Sarkar, Guy Pratt, Tom Taghon, Sarah Dimeloe, Ulrich L. Günther, Christian Ludwig, Maarten Hoogenkamp

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NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency by Congxin Sun, Elena Seranova, Malkiel A. Cohen, Miruna Chipara, Jennie Roberts, Dewi Astuti, Adina M. Palhegyi, Animesh Acharjee, Lucia Sedlackova, Tetsushi Kataura, Elsje G. Otten, Prashanta K. Panda, Samuel Lara-Reyna, Miriam E. Korsgen, Kevin J. Kauffman, Alejandro Huerta-Uribe, Malgorzata Zatyka, Luiz F.S.E. Silva, Jorge Torresi, Shupei Zhang, Georgina W. Hughes, Carl Ward, Erich R. Kuechler, David Cartwright, Sergey Trushin, Eugenia Trushina, Gaurav Sahay, Yosef Buganim, Gareth G. Lavery, Joerg Gsponer, Daniel G. Anderson, Eva-Maria Frickel, Tatiana R. Rosenstock, Timothy Barrett, Oliver D.K. Maddocks, Daniel A. Tennant, Haoyi Wang, Rudolf Jaenisch, Viktor I. Korolchuk, Sovan Sarkar

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