Chronic Exposure to Nitric Oxide Induces P53 Mutations and Malignant-like Features in Human Breast Epithelial Cells by Robert Y. S. Cheng, Sandra Burkett, Stefan Ambs, Terry Moody, David A. Wink, Lisa A. Ridnour

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Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2. by Suzanne A Hartford, Rajanikant Chittela, Xia Ding, Aradhana Vyas, Betty Martin, Sandra Burkett, Diana C Haines, Eileen Southon, Lino Tessarollo, Shyam K Sharan

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BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage by Kajal Biswas, Subha Philip, Aditya Yadav, Betty K. Martin, Sandra Burkett, Vaibhav Singh, Anav Babbar, Susan Lynn North, Suhwan Chang, Shyam K. Sharan

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Six induced pluripotent stem cell lines from fibroblasts of individuals with CLN3-related conditions by Ewelina Dwojak, Danielle O’Mard, Jizhong Zou, Christopher A. Wassif, Sandra Burkett, Michael Eckhaus, Fabio Rueda Faucz, Cameron Padilla, Rafael Villasmil, Wei Zheng, An N. Dang Do

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The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation by Xiaoping Xu, Kai Ni, Yafeng He, Jianke Ren, Chongkui Sun, Yie Liu, Mirit I. Aladjem, Sandra Burkett, Richard Finney, Xia Ding, Shyam K. Sharan, Kathrin Muegge

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Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases. by Olga Aprelikova, Christine C Tomlinson, Mark Hoenerhoff, Julie A Hixon, Scott K Durum, Ting-Hu Qiu, Siping He, Sandra Burkett, Zi-Yao Liu, Steven M Swanson, Jeffrey E Green

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An IKKα-Nucleophosmin Axis Utilizes Inflammatory Signaling to Promote Genome Integrity by Xiaojun Xia, Shuang Liu, Zuoxiang Xiao, Feng Zhu, Na-Young Song, Ming Zhou, Bigang Liu, Jianjun Shen, Kunio Nagashima, Timothy D. Veenstra, Sandra Burkett, Mahesh Datla, Jami Willette-Brown, Haifa Shen, Yinling Hu

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Loss of Brca1 and Trp53 in adult mouse mammary ductal epithelium results in development of hormone receptor-positive or hormone receptor-negative tumors, depending on inactivation... by Ludmila Szabova, Melanie B. Gordon, Lucy Lu, Nathan Pate, Laura Bassel, Anthony J. Iacovelli, Baktiar Karim, Philip J. Homan, Deborah B. Householder, Theresa M. Guerin, Sandra Burkett, Amanda M. Day, Wendi Custer, Zoe Weaver Ohler

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Saturation genome editing of 11 codons and exon 13 of BRCA2 coupled with chemotherapeutic drug response accurately determines pathogenicity of variants. by Sounak Sahu, Teresa L Sullivan, Alexander Y Mitrophanov, Mélissa Galloux, Darryl Nousome, Eileen Southon, Dylan Caylor, Arun Prakash Mishra, Christine N Evans, Michelle E Clapp, Sandra Burkett, Tyler Malys, Raj Chari, Kajal Biswas, Shyam K Sharan

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Thymidylate synthase accelerates Men1-mediated pancreatic tumor progression and reduces survival by Vinod Vijayakurup, Kyungah Maeng, Hye Seung Lee, Benjamin Meyer, Sandra Burkett, Akbar Nawab, Michael W. Dougherty, Christian Jobin, Iqbal Mahmud, Timothy J. Garrett, Michael Feely, Kyoung Bun Lee, Frederic J. Kaye, Maria V. Guijarro, Maria Zajac-Kaye

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Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant by Arun Prakash Mishra, Suzanne Hartford, Rajani Kant Chittela, Sounak Sahu, Suhas S. Kharat, Lucia Alvaro-Aranda, Aida Contreras-Perez, Teresa Sullivan, Betty K. Martin, Mary Albaugh, Eileen Southon, Sandra Burkett, Baktiar Karim, Aura Carreira, Lino Tessarollo, Shyam K. Sharan

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Gene-edited pseudogene resurrection corrects p47phox-deficient chronic granulomatous disease by Randall K. Merling, Douglas B. Kuhns, Colin L. Sweeney, Xiaolin Wu, Sandra Burkett, Jessica Chu, Janet Lee, Sherry Koontz, Giovanni Di Pasquale, Sandra A. Afione, John A. Chiorini, Elizabeth M. Kang, Uimook Choi, Suk See De Ravin, Harry L. Malech

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BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at replication-induced and meiotic DNA double strand breaks by Arun Prakash Mishra, Suzanne A. Hartford, Sounak Sahu, Kimberly Klarmann, Rajani Kant Chittela, Kajal Biswas, Albert B. Jeon, Betty K. Martin, Sandra Burkett, Eileen Southon, Susan Reid, Mary E. Albaugh, Baktiar Karim, Lino Tessarollo, Jonathan R. Keller, Shyam K. Sharan

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Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response by Ruhul Amin, Anjali Shukla, Jacqueline Jufen Zhu, Sohyoung Kim, Ping Wang, Simon Zhongyuan Tian, Andy D. Tran, Debasish Paul, Steven D. Cappell, Sandra Burkett, Huaitian Liu, Maxwell P. Lee, Michael J. Kruhlak, Jennifer E. Dwyer, R. Mark Simpson, Gordon L. Hager, Yijun Ruan, Kent W. Hunter

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A novel mouse model of PMS2 founder mutation that causes mismatch repair defect due to aberrant splicing by Kajal Biswas, Martin Couillard, Luca Cavallone, Sandra Burkett, Stacey Stauffer, Betty K. Martin, Eileen Southon, Susan Reid, Teri M. Plona, Ryan N. Baugher, Stephanie D. Mellott, Kristen M. Pike, Mary E. Albaugh, Chelsea Maedler-Kron, Nancy Hamel, Lino Tessarollo, Victoria Marcus, William D. Foulkes, Shyam K. Sharan

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Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies by Xia Ding, Arnab Ray Chaudhuri, Elsa Callen, Yan Pang, Kajal Biswas, Kimberly D. Klarmann, Betty K. Martin, Sandra Burkett, Linda Cleveland, Stacey Stauffer, Teresa Sullivan, Aashish Dewan, Hanna Marks, Anthony T. Tubbs, Nancy Wong, Eugen Buehler, Keiko Akagi, Scott E. Martin, Jonathan R. Keller, André Nussenzweig, Shyam K. Sharan

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Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer by Yurong Song, Travis D. Kerr, Chelsea Sanders, Lisheng Dai, Shaneen S. Baxter, Brandon Somerville, Ryan N. Baugher, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Teri M. Plona, Bingfang Xu, Lei Wei, Qiang Hu, Song Liu, Alan Hutson, Baktiar Karim, Sandra Burkett, Simone Difilippantonio, Ligia Pinto, Johannes Gebert, Matthias Kloor, Steven M. Lipkin, Shizuko Sei, Robert H. Shoemaker

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Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas. by Yuwei Zhang, Rodrigo Calado, Mahadev Rao, Julie A Hong, Alan K Meeker, Bogdan Dumitriu, Scott Atay, Peter J McCormick, Susan H Garfield, Danny Wangsa, Hesed M Padilla-Nash, Sandra Burkett, Mary Zhang, Tricia F Kunst, Nathan R Peterson, Sichuan Xi, Suzanne Inchauste, Nasser K Altorki, Alan G Casson, David G Beer, Curtis C Harris, Thomas Ried, Neal S Young, David S Schrump

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