Hasil Pencarian - Rolf Hilgenfeld

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  1. 1
    Evidence for a two-metal-ion mechanism in the cytidyltransferase KdsB, an enzyme involved in lipopolysaccharide biosynthesis.

    Evidence for a two-metal-ion mechanism in the cytidyltransferase KdsB, an enzyme involved in lipopolysaccharide biosynthesis. oleh Helgo Schmidt, Jeroen R Mesters, Jing Wu, Ronald W Woodard, Rolf Hilgenfeld, Uwe Mamat

    Diterbitkan 2011-01-01
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  2. 2
    From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease

    From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease oleh Matthias Göhl, Linlin Zhang, Haifa El Kilani, Xinyuanyuan Sun, Kaixuan Zhang, Mark Brönstrup, Rolf Hilgenfeld

    Diterbitkan 2022-07-01
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  3. 3
    Identification of a Dual Inhibitor of Secreted Phospholipase A<sub>2</sub> (GIIA sPLA<sub>2</sub>) and SARS-CoV-2 Main Protease

    Identification of a Dual Inhibitor of Secreted Phospholipase A<sub>2</sub> (GIIA sPLA<sub>2</sub>) and SARS-CoV-2 Main Protease oleh Maria A. Theodoropoulou, Giorgos S. Koutoulogenis, Linlin Zhang, Ifigeneia Akrani, Emmanuel Mikros, Rolf Hilgenfeld, George Kokotos

    Diterbitkan 2022-08-01
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  4. 4
    Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold

    Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold oleh Wei Liang Tan, Ka H. Wong, Jian Lei, Naoki Sakai, Hong Wei Tan, Rolf Hilgenfeld, James P. Tam

    Diterbitkan 2017-07-01
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  5. 5
    Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

    Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments oleh Daniel Becker, Zuzanna Kaczmarska, Christoph Arkona, Robert Schulz, Carolin Tauber, Gerhard Wolber, Rolf Hilgenfeld, Miquel Coll, Jörg Rademann

    Diterbitkan 2016-09-01
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  6. 6
    Why is the Omicron main protease of SARS-CoV-2 less stable than its wild-type counterpart? A crystallographic, biophysical, and theoretical study

    Why is the Omicron main protease of SARS-CoV-2 less stable than its wild-type counterpart? A crystallographic, biophysical, and theoretical study oleh Mohamed Ibrahim, Xinyuanyuan Sun, Vinicius Martins de Oliveira, Ruibin Liu, Joseph Clayton, Haifa El Kilani, Jana Shen, Rolf Hilgenfeld

    Diterbitkan 2024-08-01
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  7. 7
    Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

    Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication oleh Jenny Kouretova, M. Zouhir Hammamy, Anton Epp, Kornelia Hardes, Stephanie Kallis, Linlin Zhang, Rolf Hilgenfeld, Ralf Bartenschlager, Torsten Steinmetzer

    Diterbitkan 2017-01-01
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  8. 8
    Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes.

    Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes. oleh Annika Rennenberg, Christine Lehmann, Anna Heitmann, Tina Witt, Guido Hansen, Krishna Nagarajan, Christina Deschermeier, Vito Turk, Rolf Hilgenfeld, Volker T Heussler

    Diterbitkan 2010-03-01
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  9. 9
    The SARS-unique domain (SUD) of SARS coronavirus contains two macrodomains that bind G-quadruplexes.

    The SARS-unique domain (SUD) of SARS coronavirus contains two macrodomains that bind G-quadruplexes. oleh Jinzhi Tan, Clemens Vonrhein, Oliver S Smart, Gerard Bricogne, Michela Bollati, Yuri Kusov, Guido Hansen, Jeroen R Mesters, Christian L Schmidt, Rolf Hilgenfeld

    Diterbitkan 2009-05-01
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  10. 10
    Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts

    Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts oleh Daniel Jan Strub, Michał Talma, Maria Strub, Wioletta Rut, Mikolaj Zmudzinski, Władysław Brud, Johan Neyts, Laura Vangeel, Linlin Zhang, Xinyuanyuan Sun, Zongyang Lv, Digant Nayak, Shaun K. Olsen, Rolf Hilgenfeld, Dirk Jochmans, Marcin Drąg

    Diterbitkan 2022-08-01
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  11. 11
    Design of wide-spectrum inhibitors targeting coronavirus main proteases.

    Design of wide-spectrum inhibitors targeting coronavirus main proteases. oleh Haitao Yang, Weiqing Xie, Xiaoyu Xue, Kailin Yang, Jing Ma, Wenxue Liang, Qi Zhao, Zhe Zhou, Duanqing Pei, John Ziebuhr, Rolf Hilgenfeld, Kwok Yung Yuen, Luet Wong, Guangxia Gao, Saijuan Chen, Zhu Chen, Dawei Ma, Mark Bartlam, Zihe Rao

    Diterbitkan 2005-10-01
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  12. 12
    Correction: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.

    Correction: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases. oleh Haitao Yang, Weiqing Xie, Xiaoyu Xue, Kailin Yang, Jing Ma, Wenxue Liang, Qi Zhao, Zhe Zhou, Duanqing Pei, John Ziebuhr, Rolf Hilgenfeld, Kwok Yung Yuen, Luet Wong, Guangxia Gao, Saijuan Chen, Zhu Chen, Dawei Ma, Mark Bartlam, Zihe Rao

    Diterbitkan 2005-11-01
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  13. 13
    Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase

    Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase oleh Mikolaj Zmudzinski, Wioletta Rut, Kamila Olech, Jarosław Granda, Mirosław Giurg, Małgorzata Burda-Grabowska, Rafał Kaleta, Michala Zgarbova, Renata Kasprzyk, Linlin Zhang, Xinyuanyuan Sun, Zongyang Lv, Digant Nayak, Malgorzata Kesik-Brodacka, Shaun K. Olsen, Jan Weber, Rolf Hilgenfeld, Jacek Jemielity, Marcin Drag

    Diterbitkan 2023-06-01
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  14. 14
    Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design

    Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design oleh Lisa-Marie Funk, Gereon Poschmann, Fabian Rabe von Pappenheim, Ashwin Chari, Kim M. Stegmann, Antje Dickmanns, Marie Wensien, Nora Eulig, Elham Paknia, Gabi Heyne, Elke Penka, Arwen R. Pearson, Carsten Berndt, Tobias Fritz, Sophia Bazzi, Jon Uranga, Ricardo A. Mata, Matthias Dobbelstein, Rolf Hilgenfeld, Ute Curth, Kai Tittmann

    Diterbitkan 2024-01-01
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  15. 15
    The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors.

    The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors. oleh Susanne Pfefferle, Julia Schöpf, Manfred Kögl, Caroline C Friedel, Marcel A Müller, Javier Carbajo-Lozoya, Thorsten Stellberger, Ekatarina von Dall'Armi, Petra Herzog, Stefan Kallies, Daniela Niemeyer, Vanessa Ditt, Thomas Kuri, Roland Züst, Ksenia Pumpor, Rolf Hilgenfeld, Frank Schwarz, Ralf Zimmer, Imke Steffen, Friedemann Weber, Volker Thiel, Georg Herrler, Heinz-Jürgen Thiel, Christel Schwegmann-Wessels, Stefan Pöhlmann, Jürgen Haas, Christian Drosten, Albrecht von Brunn

    Diterbitkan 2011-10-01
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  16. 16
    Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

    Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication oleh Dorothée Bardiot, Laura Vangeel, Mohamed Koukni, Philippe Arzel, Marleen Zwaagstra, Heyrhyoung Lyoo, Patrick Wanningen, Shamshad Ahmad, Linlin Zhang, Xinyuanyuan Sun, Adrien Delpal, Cecilia Eydoux, Jean-Claude Guillemot, Eveline Lescrinier, Hugo Klaassen, Pieter Leyssen, Dirk Jochmans, Karolien Castermans, Rolf Hilgenfeld, Colin Robinson, Etienne Decroly, Bruno Canard, Eric J. Snijder, Martijn J. van Hemert, Frank van Kuppeveld, Patrick Chaltin, Johan Neyts, Steven De Jonghe, Arnaud Marchand

    Diterbitkan 2022-02-01
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