Hasil Pencarian - Richard T. Timms

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  1. 1
    ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

    ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex oleh Richard T. Timms, Iva A. Tchasovnikarova, Robin Antrobus, Gordon Dougan, Paul J. Lehner

    Diterbitkan 2016-10-01
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  2. 2
    Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells.

    Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells. oleh Lidia M Duncan, Richard T Timms, Eszter Zavodszky, Florencia Cano, Gordon Dougan, Felix Randow, Paul J Lehner

    Diterbitkan 2012-01-01
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  3. 3
    Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

    Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms oleh Christopher H. Douse, Stuart Bloor, Yangci Liu, Maria Shamin, Iva A. Tchasovnikarova, Richard T. Timms, Paul J. Lehner, Yorgo Modis

    Diterbitkan 2018-02-01
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  4. 4
    The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

    The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1 oleh Sam A Menzies, Norbert Volkmar, Dick JH van den Boomen, Richard T Timms, Anna S Dickson, James A Nathan, Paul J Lehner

    Diterbitkan 2018-12-01
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  5. 5
    Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases.

    Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases. oleh Richard T Timms, Lidia M Duncan, Iva A Tchasovnikarova, Robin Antrobus, Duncan L Smith, Gordon Dougan, Michael P Weekes, Paul J Lehner

    Diterbitkan 2013-01-01
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  6. 6
    Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

    Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens oleh Richard T. Timms, Sam A. Menzies, Iva A. Tchasovnikarova, Lea C. Christensen, James C. Williamson, Robin Antrobus, Gordon Dougan, Lars Ellgaard, Paul J. Lehner

    Diterbitkan 2016-06-01
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  7. 7
    Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase

    Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase oleh Xinyan Chen, Anat Raiff, Shanshan Li, Qiong Guo, Jiahai Zhang, Hualin Zhou, Richard T. Timms, Xuebiao Yao, Stephen J. Elledge, Itay Koren, Kaiming Zhang, Chao Xu

    Diterbitkan 2024-04-01
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  8. 8
    TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

    TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control oleh Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis

    Diterbitkan 2020-10-01
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