Shifting Gears in Precision Oncology—Challenges and Opportunities of Integrative Data Analysis by Ka-Won Noh, Reinhard Buettner, Sebastian Klein

Get full text

A heart-hand syndrome gene: Tfap2b plays a critical role in the development and remodeling of mouse ductus arteriosus and limb patterning. by Feng Zhao, Anja-Katrin Bosserhoff, Reinhard Buettner, Markus Moser

Get full text

Diffusion kernel-based predictive modeling of KRAS dependency in KRAS wild type cancer cell lines by Bastian Ulmer, Margarete Odenthal, Reinhard Buettner, Wilfried Roth, Michael Kloth

Get full text

AP-2δ is a crucial transcriptional regulator of the posterior midbrain. by Katrin Hesse, Kristina Vaupel, Simone Kurt, Reinhard Buettner, Jutta Kirfel, Markus Moser

Get full text

SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance. by Soyoung Lim, Astrid Becker, Andreas Zimmer, Jianrong Lu, Reinhard Buettner, Jutta Kirfel

Get full text

Proteomic analysis of pleomorphic dermal sarcoma reveals a fibroblastic cell of origin and distinct immune evasion mechanisms by Sebastian Klein, Yuri Tolkach, Hans Christian Reinhardt, Reinhard Buettner, Alexander Quaas, Doris Helbig

Get full text

Concurrent KRAS p.G12C mutation and ANK3::RET fusion in a patient with metastatic colorectal cancer: a case report by Tillmann Bedau, Carina Heydt, Udo Siebolts, Thomas Zander, Max Kraemer, Heike Loeser, Reinhard Buettner, Alexander Quaas

Get full text

Cardiac metastasis causes paradoxical malignant embolism by Britta Janina Wagner, Hans‐Peter Hobbach, Anastasia Janina Hobbach, Lena Katharina Hieggelke, Martin Grond, Nadejda Monsefi, Reinhard Buettner

Get full text

First report on two cases of pleomorphic dermal sarcoma successfully treated with immune checkpoint inhibitors by Sebastian Klein, Oana-Diana Persa, Cornelia Mauch, Ka-Won Noh, Roberto Pappesch, Svenja Wagener-Ryczek, Reinhard Buettner, Alexander Quaas, Doris Helbig

Get full text

Fetal gut cell-like differentiation in esophageal adenocarcinoma defines a rare tumor subtype with therapeutically relevant claudin-6 positivity and SWI/SNF gene alteration by Max Kraemer, Thomas Zander, Hakan Alakus, Reinhard Buettner, Su Ir Lyu, Adrian Georg Simon, Wolfgang Schroeder, Christiane J. Bruns, Alexander Quaas

Get full text

Indoleamine 2,3-Dioxygenase (IDO) Expression Is an Independent Prognostic Marker in Esophageal Adenocarcinoma by Heike Loeser, Max Kraemer, Florian Gebauer, Christiane Bruns, Wolfgang Schröder, Thomas Zander, Hakan Alakus, Arnulf Hoelscher, Reinhard Buettner, Philipp Lohneis, Alexander Quaas

Get full text

Mesothelin expression in esophageal adenocarcinoma and squamous cell carcinoma and its possible impact on future treatment strategies by Valeska Moentenich, Erdem Comut, Florian Gebauer, Armin Tuchscherer, Christiane Bruns, Wolfgang Schroeder, Reinhard Buettner, Hakan Alakus, Heike Loeser, Thomas Zander, Alexander Quaas

Get full text

Why loss of Y? A pan-cancer genome analysis of tumors with loss of Y chromosome by Philipp Müller, Oscar Velazquez Camacho, Ali M. Yazbeck, Christina Wölwer, Weiwei Zhai, Johannes Schumacher, Dominik Heider, Reinhard Buettner, Alexander Quaas, Axel M. Hillmer

Get full text

Genomic Characterization of TP53–Wild-Type Esophageal Carcinoma by Alexander Quaas, Carina Heydt, Florian Gebauer, Hakan Alakus, Heike Loeser, Reinhard Buettner, Axel Hillmer, Christiane Bruns, Sabine Merkelbach-Bruse, Thomas Zander, Peter Frommolt

Get full text

The expression of the immune checkpoint regulator VISTA correlates with improved overall survival in pT1/2 tumor stages in esophageal adenocarcinoma by Heike Loeser, Max Kraemer, Florian Gebauer, Christiane Bruns, Wolfgang Schröder, Thomas Zander, Oana-Diana Persa, Hakan Alakus, Arnulf Hoelscher, Reinhard Buettner, Philipp Lohneis, Alexander Quaas

Get full text

Tumour area infiltration and cell count in endoscopic biopsies of therapy-naive upper GI tract carcinomas by QuPath analysis: implications for predictive biomarker testing by Andreas H. Scheel, Hannah Lamberty, Yuri Tolkach, Florian Gebauer, Birgid Schoemig-Markiefka, Thomas Zander, Reinhard Buettner, Josef Rueschoff, Christiane Josephine Bruns, Wolfgang Schroeder, Alexander Quaas

Get full text

Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model. by Katharina König, Lydia Meder, Cornelia Kröger, Linda Diehl, Alexandra Florin, Ursula Rommerscheidt-Fuss, Philip Kahl, Eva Wardelmann, Thomas M Magin, Reinhard Buettner, Lukas C Heukamp

Get full text

Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma by Simon Schallenberg, Julian Bork, Ahlem Essakly, Hakan Alakus, Reinhard Buettner, Axel M. Hillmer, Christiane Bruns, Wolfgang Schroeder, Thomas Zander, Heike Loeser, Florian Gebauer, Alexander Quaas

Get full text

PIK3CA and KRAS Amplification in Esophageal Adenocarcinoma and their Impact on the Inflammatory Tumor Microenvironment and Prognosis by Ahlem Essakly, Heike Loeser, Max Kraemer, Hakan Alakus, Seung-Hun Chon, Thomas Zander, Reinhard Buettner, Axel M. Hillmer, Christiane J. Bruns, Wolfgang Schroeder, Florian Gebauer, Alexander Quaas

Get full text

The LIM-only protein FHL2 reduces vascular lesion formation involving inhibition of proliferation and migration of smooth muscle cells. by Kondababu Kurakula, Mariska Vos, Iker Otermin Rubio, Goran Marinković, Reinhard Buettner, Lukas C Heukamp, Jan Stap, Vivian de Waard, Claudia M van Tiel, Carlie J M de Vries

Get full text