Hasil Pencarian - Len Neckers

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  1. 1
    The Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors

    The Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors oleh Abhinav Joshi, Takeshi Ito, Didier Picard, Len Neckers

    Diterbitkan 2022-06-01
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  2. 2
    ErbB2 and NFκB overexpression as predictors of chemoradiation resistance and putative targets to overcome resistance in muscle-invasive bladder cancer.

    ErbB2 and NFκB overexpression as predictors of chemoradiation resistance and putative targets to overcome resistance in muscle-invasive bladder cancer. oleh Fumitaka Koga, Soichiro Yoshida, Manabu Tatokoro, Satoru Kawakami, Yasuhisa Fujii, Jiro Kumagai, Len Neckers, Kazunori Kihara

    Diterbitkan 2011-01-01
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  3. 3
    Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.

    Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism. oleh Céline Douarre, Carole Sourbier, Ilaria Dalla Rosa, Benu Brata Das, Christophe E Redon, Hongliang Zhang, Len Neckers, Yves Pommier

    Diterbitkan 2012-01-01
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  4. 4
    Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma.

    Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma. oleh Alessio Giubellino, Carole Sourbier, Min-Jung Lee, Brad Scroggins, Petra Bullova, Michael Landau, Weiwen Ying, Len Neckers, Jane B Trepel, Karel Pacak

    Diterbitkan 2013-01-01
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  5. 5
    Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics

    Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics oleh Qingdi Quentin Li, Jian-Jiang Hao, Zheng Zhang, L. Spencer Krane, Kai H. Hammerich, Thomas Sanford, Jane B. Trepel, Len Neckers, Piyush K. Agarwal

    Diterbitkan 2017-03-01
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  6. 6
    Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation

    Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation oleh Ashleigh B. Bachman, Dimitra Keramisanou, Wanping Xu, Kristin Beebe, Michael A. Moses, M. V. Vasantha Kumar, Geoffrey Gray, Radwan Ebna Noor, Arjan van der Vaart, Len Neckers, Ioannis Gelis

    Diterbitkan 2018-01-01
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  7. 7
    HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts

    HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts oleh Nina H. Pipalia, Syed Z. Saad, Kanagaraj Subramanian, Abigail Cross, Aisha al-Motawa, Kunal Garg, Brian S.J. Blagg, Len Neckers, Paul Helquist, Olaf Wiest, Daniel S. Ory, Frederick R. Maxfield

    Diterbitkan 2021-01-01
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  8. 8
    Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.

    Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants. oleh Thomas L Prince, Toshiki Kijima, Manabu Tatokoro, Sunmin Lee, Shinji Tsutsumi, Kendrick Yim, Candy Rivas, Sylvia Alarcon, Harvey Schwartz, Kofi Khamit-Kush, Bradley T Scroggins, Kristin Beebe, Jane B Trepel, Len Neckers

    Diterbitkan 2015-01-01
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  9. 9
    HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

    HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation oleh Toshiki Kijima, Thomas L. Prince, Megan L. Tigue, Kendrick H. Yim, Harvey Schwartz, Kristin Beebe, Sunmin Lee, Marek A. Budzynski, Heinric Williams, Jane B. Trepel, Lea Sistonen, Stuart Calderwood, Len Neckers

    Diterbitkan 2018-05-01
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  10. 10
    Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1

    Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1 oleh Wanping Xu, Kristin Beebe, Juan D. Chavez, Marta Boysen, YinYing Lu, Abbey D. Zuehlke, Dimitra Keramisanou, Jane B. Trepel, Christosomos Prodromou, Matthias P. Mayer, James E. Bruce, Ioannis Gelis, Len Neckers

    Diterbitkan 2019-06-01
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  11. 11
    The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis

    The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis oleh Abhinav Joshi, Li Dai, Yanxin Liu, Jungsoon Lee, Nastaran Mohammadi Ghahhari, Gregory Segala, Kristin Beebe, Lisa M. Jenkins, Gaelyn C. Lyons, Lilia Bernasconi, Francis T. F. Tsai, David A. Agard, Len Neckers, Didier Picard

    Diterbitkan 2020-01-01
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  12. 12
    Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma

    Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma oleh Roma Pahwa, Janhavi Dubhashi, Anand Singh, Parthav Jailwala, Alexei Lobanov, Craig J. Thomas, Michele Ceribelli, Kelli Wilson, Christopher J. Ricketts, Cathy D. Vocke, Catherine Wells, Donald P. Bottaro, W. Marston Linehan, Len Neckers, Ramaprasad Srinivasan

    Diterbitkan 2022-06-01
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  13. 13
    An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans

    An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans oleh Abbey D. Zuehlke, Michael Reidy, Coney Lin, Paul LaPointe, Sarah Alsomairy, D. Joshua Lee, Genesis M. Rivera-Marquez, Kristin Beebe, Thomas Prince, Sunmin Lee, Jane B. Trepel, Wanping Xu, Jill Johnson, Daniel Masison, Len Neckers

    Diterbitkan 2017-05-01
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  14. 14
    Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target.

    Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target. oleh Mariëlle I Gallegos Ruiz, Karijn Floor, Paul Roepman, José A Rodriguez, Gerrit A Meijer, Wolter J Mooi, Ewa Jassem, Jacek Niklinski, Thomas Muley, Nico van Zandwijk, Egbert F Smit, Kristin Beebe, Len Neckers, Bauke Ylstra, Giuseppe Giaccone

    Diterbitkan 2008-03-01
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  15. 15
    Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

    Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors oleh Mark R. Woodford, Andrew W. Truman, Diana M. Dunn, Sandra M. Jensen, Richard Cotran, Renee Bullard, Mourad Abouelleil, Kristin Beebe, Donald Wolfgeher, Sara Wierzbicki, Dawn E. Post, Tiffany Caza, Shinji Tsutsumi, Barry Panaretou, Stephen J. Kron, Jane B. Trepel, Steve Landas, Chrisostomos Prodromou, Oleg Shapiro, William G. Stetler-Stevenson, Dimitra Bourboulia, Len Neckers, Gennady Bratslavsky, Mehdi Mollapour

    Diterbitkan 2016-02-01
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  16. 16
    c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

    c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells oleh Diana M. Dunn, Mark R. Woodford, Andrew W. Truman, Sandra M. Jensen, Jacqualyn Schulman, Tiffany Caza, Taylor C. Remillard, David Loiselle, Donald Wolfgeher, Brian S.J. Blagg, Lucas Franco, Timothy A. Haystead, Soumya Daturpalli, Matthias P. Mayer, Jane B. Trepel, Rhodri M.L. Morgan, Chrisostomos Prodromou, Stephen J. Kron, Barry Panaretou, William G. Stetler-Stevenson, Steve K. Landas, Len Neckers, Gennady Bratslavsky, Dimitra Bourboulia, Mehdi Mollapour

    Diterbitkan 2015-08-01
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