Vaccinating against cancer: getting to prime time by Lawrence Fong, Ryan Chang

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Shuffling the deck with CTLA-4 therapy: Deep sequencing of rearranged TCRB genes demonstrates T cell repertoire remodeling in cancer patients by Edward Cha, Lawrence Fong

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Editorial: Advancements in immunology and immunotherapy for breast cancer by Tomoharu Sugie, Roberto Salgado, Roberto Salgado, Lawrence Fong

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Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response by Bridget P. Keenan, Lawrence Fong, Robin K. Kelley

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E-cigarette exposure disrupts antitumor immunity and promotes metastasis by Marcel Arias-Badia, Chien-Chun Steven Pai, PeiXi Chen, Anthony Chang, Yee May Lwin, Aahir Srinath, Jeffrey E. Gotts, Stanton A. Glantz, Stanton A. Glantz, Stanton A. Glantz, Lawrence Fong, Lawrence Fong, Lawrence Fong

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Interplay between CD8α+ dendritic cells and monocytes in response to Listeria monocytogenes infection attenuates T cell responses. by Dilnawaz Kapadia, Aida Sadikovic, Yannick Vanloubbeeck, Dirk Brockstedt, Lawrence Fong

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Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy by Riyue Bao, Aung Naing, Lawrence Fong, Jason J. Luke, Robert D. Leone, Ryan C. Augustin

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548 Evolution of myeloid-mediated mechanisms of immunotherapy resistance at single-cell resolution with human prostate cancer progression by Lawrence Fong, Eliezer Van Allen, Alec Starzinski, Zenghua Fan, Diamond Luong, Aram Lyu, Ali Setayesh

Neoadjuvant sipuleucel-T induces both Th1 activation and immune regulation in localized prostate cancer by Katsunobu Hagihara, Stephen Chan, Li Zhang, David Y. Oh, Xiao X. Wei, Jeffry Simko, Lawrence Fong

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423 A phase 2 study of ibrutinib as neoadjuvant therapy in patients with localized prostate cancer by Lawrence Fong, Russell Pachynski, Peter Oppelt, Melissa Reimers, Cody Weimholt, Katie Slane, Jason Frankel, Robert Figenshau, Eric Kim, Gerald Andriole

TCR Convergence in Individuals Treated With Immune Checkpoint Inhibition for Cancer by Timothy John Looney, Denise Topacio-Hall, Geoffrey Lowman, Jeffrey Conroy, Jeffrey Conroy, Carl Morrison, Carl Morrison, David Oh, Lawrence Fong, Li Zhang

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263 Pleiotropic effects of IL-7 in prostate cancer patients receiving Sipuleucel-T vaccination by Chihiro Morishima, Lawrence Fong, Holden Maecker, Leonard D’Amico, Steven Fling, Martin Cheever, Nirasha Ramchurren, Sean Bendall, Caroline Duault, Mina Pichavant, Bita Sahaf

1502 Tumor heterogeneity impedes immunotherapy through driving spatially organized pockets of immunosuppression by Lawrence Fong, Alexis Combes, Miho Tanaka, Lotus Lum, Kenneth Ng, Zoe Adams, Daphne Superville, Max Krummel, Kenneth Hu, Cecilia Ledezma-Soto, Bushra Samad, Kelly Kersten, Melissa Q Reeves

In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET by Ning Zhao, Conner Bardine, André Luiz Lourenço, Yung-hua Wang, Yangjie Huang, Simon J. Cleary, David M. Wilson, David Y. Oh, Lawrence Fong, Mark R. Looney, Michael J. Evans, Charles S. Craik

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676 Altered circulating myeloid states associated with anti-PD-1 resistance induce T cell paralysis in human biliary cancer by Li Zhang, David Lee, Yang Sun, Lawrence Fong, Kathryn Allaire, Alexander Cheung, Elizabeth McCarthy, Bridget Keenan, Arielle Ilano, Hai Yang, Zenghua Fan, Tony Li, Hewitt Chang, Brenna Sheldon, Robin Kelley, Chun Jimmie Ye

Phase II Study of Ipilimumab in Men With Metastatic Prostate Cancer With an Incomplete Response to Androgen Deprivation Therapy by Julie N. Graff, Julie N. Graff, Mark N. Stein, Rishi Surana, Luai Al Rabadi, Luai Al Rabadi, Eric Liu, Lawrence Fong, Shawna Bailey, Emile Latour, Timothy A. Newby, Amy E. Moran, Tomasz M. Beer

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Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity by David Wang, Jason Quiros, Kelly Mahuron, Chien-Chun Pai, Valeria Ranzani, Arabella Young, Stephanie Silveria, Tory Harwin, Arbi Abnousian, Massimiliano Pagani, Michael D. Rosenblum, Frederic Van Gool, Lawrence Fong, Jeffrey A. Bluestone, Michel DuPage

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1361 Neoadjuvant CD40 agonism remodels the tumor immune microenvironment in locally advanced esophageal/gastroesophageal junction cancer by Li Zhang, Lawrence Fong, Andrew H Ko, Brandon Chen, Alexander Cheung, Alec Starzinski, Hai Yang, Tony Li, Bridget P Keenan, Maira Soto, Erin L Filbert, Stephanie Starzinski, Marissa Gin, Phi Le, Brandon Bol, Frank J Hsu

759 ADPORT-601 (TT-10–101): first-in-human study of adenosine 2A (A2A) and adenosine 2B (A2B) receptor antagonists in participants with selected advanced solid tumors by Lawrence Fong, Sumit Subudhi, Gerald S Falchook, Russell Pachynski, Anthony El-Khoueiry, Ian Walters, Robert Krämer, Sushant Kumar, Kasim Mookhtiar, Justin Fairchild, Mohamad A Salkeni, Jaspreet Grewal, William Tester, Samik Upadhaya, Ana Rosa Saez Ibanez, Desa Rae Stanton-Pastore

862 TLR9 agonism promotes cytotoxic T cell persistence and myeloid remodeling when combined with radiation therapy and PD-1 blockade in oligometastatic prostate cancer patients by Li Zhang, Lawrence Fong, David Y Oh, Eliezer Van Allen, Felix Y Feng, Anthony Wong, Eric J Small, Terence W Friedlander, Alec Starzinski, Zenghua Fan, Tony Li, Hewitt Chang, Marissa Gin, Katsuto Shinohara, Hao Nguyen, Caleb Hwang, Christopher De Leon, Rahul R Aggarwal