Search Results - Kenneth R. Chien

Kenneth R. Chien

Kenneth R. Chien (born 1951) is an American doctor and medical scientist who has been a research director at Karolinska Institute, in Stockholm, since 2013. Chien has several papers with over 1,000 citations and a h-index of 132. His area of expertise is cardiovascular science. His research into regenerative cardiovascular medicine, specifically while director of the Cardiovascular Program of the Harvard Stem Cell Institute, led to his co-founding, in 2010, of ModeRNA Therapeutics. In 2018, the company re-branded as Moderna, Inc. Chien is a recipient of the Walter Bradford Cannon Award of the American Physiology Society and the Pasarow Award. He is a member of the Norwegian Academy of Science and Letters, the Austrian Academy of Sciences, and has received an honorary doctorate from the University of Edinburgh. Provided by Wikipedia
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  1. 1
    Alchemy and the new age of cardiac muscle cell biology.

    Alchemy and the new age of cardiac muscle cell biology. by Kenneth R Chien

    Published 2005-04-01
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  2. 2
    Isolation of human ESC-derived cardiac derivatives and embryonic heart cells for population and single-cell RNA-seq analysis

    Isolation of human ESC-derived cardiac derivatives and embryonic heart cells for population and single-cell RNA-seq analysis by Federica Santoro, Kenneth R. Chien, Makoto Sahara

    Published 2021-03-01
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  3. 3
    Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA

    Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA by Kathy O. Lui, Lior Zangi, Kenneth R. Chien

    Published 2014-11-01
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  4. 4
    In search of the next super models

    In search of the next super models by Alexander Goedel, Niels Grote Beverborg, Makoto Sahara, Kenneth R Chien

    Published 2019-12-01
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  5. 5
    The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload.

    The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload. by Marie-Louise Bang, Yusu Gu, Nancy D Dalton, Kirk L Peterson, Kenneth R Chien, Ju Chen

    Published 2014-01-01
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  6. 6
    An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation

    An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation by Eduarde Rohner, Nevin Witman, Jesper Sohlmer, Erwin De Genst, William E. Louch, Makoto Sahara, Kenneth R. Chien

    Published 2021-09-01
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  7. 7
    Model‐Based Analysis Reveals a Sustained and Dose‐Dependent Acceleration of Wound Healing by VEGF‐A mRNA (AZD8601)

    Model‐Based Analysis Reveals a Sustained and Dose‐Dependent Acceleration of Wound Healing by VEGF‐A mRNA (AZD8601) by Joachim Almquist, S. Michaela Rikard, Maria Wågberg, Anthony C. Bruce, Peter Gennemark, Regina Fritsche‐Danielson, Kenneth R. Chien, Shayn M. Peirce, Kenny Hansson, Anna Lundahl

    Published 2020-07-01
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  8. 8
    Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development

    Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development by Nevin Witman, Chikai Zhou, Timm Häneke, Yao Xiao, Xiaoting Huang, Eduarde Rohner, Jesper Sohlmér, Niels Grote Beverborg, Miia L. Lehtinen, Kenneth R. Chien, Makoto Sahara

    Published 2023-09-01
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  9. 9
    Author Correction: Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development

    Author Correction: Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development by Nevin Witman, Chikai Zhou, Timm Häneke, Yao Xiao, Xiaoting Huang, Eduarde Rohner, Jesper Sohlmér, Niels Grote Beverborg, Miia L. Lehtinen, Kenneth R. Chien, Makoto Sahara

    Published 2024-01-01
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  10. 10
    Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes

    Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes by Li-Ming Gan, Maria Lagerström-Fermér, Leif G. Carlsson, Cecilia Arfvidsson, Ann-Charlotte Egnell, Anna Rudvik, Magnus Kjaer, Anna Collén, James D. Thompson, John Joyal, Ligia Chialda, Thomas Koernicke, Rainard Fuhr, Kenneth R. Chien, Regina Fritsche-Danielson

    Published 2019-02-01
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  11. 11
    Correction: Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells

    Correction: Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells by Boon-Seng Soh, Shi-Yan Ng, Hao Wu, Kristina Buac, Joo-Hye C. Park, Xiaojun Lian, Jiejia Xu, Kylie S Foo, Ulrika Felldin, Xiaobing He, Massimo Nichane, Henry Yang, Lie Bu, Ronald A Li, Bing Lim, Kenneth R Chien

    Published 2016-07-01
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  12. 12
    Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells

    Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells by Boon-Seng Soh, Shi-Yan Ng, Hao Wu, Kristina Buac, Joo-Hye C. Park, Xiaojun Lian, Jiejia Xu, Kylie S. Foo, Ulrika Felldin, Xiaobing He, Massimo Nichane, Henry Yang, Lei Bu, Ronald A. Li, Bing Lim, Kenneth R. Chien

    Published 2016-03-01
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  13. 13
    Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors

    Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors by Clara Sze Man Tang, Mimmi Mononen, Wai-Yee Lam, Sheng Chih Jin, Xuehan Zhuang, Maria-Mercè Garcia-Barcelo, Qiongfen Lin, Yujia Yang, Makoto Sahara, Elif Eroglu, Kenneth R. Chien, Haifa Hong, Paul Kwong Hang Tam, Peter J. Gruber

    Published 2022-01-01
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  14. 14
    Amnion signals are essential for mesoderm formation in primates

    Amnion signals are essential for mesoderm formation in primates by Ran Yang, Alexander Goedel, Yu Kang, Chenyang Si, Chu Chu, Yi Zheng, Zhenzhen Chen, Peter J. Gruber, Yao Xiao, Chikai Zhou, Nevin Witman, Elif Eroglu, Chuen-Yan Leung, Yongchang Chen, Jianping Fu, Weizhi Ji, Fredrik Lanner, Yuyu Niu, Kenneth R. Chien

    Published 2021-08-01
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  15. 15
    Derivation of human primordial germ cell-like cells in an embryonic-like culture

    Derivation of human primordial germ cell-like cells in an embryonic-like culture by Sajedeh Nasr Esfahani, Yi Zheng, Auriana Arabpour, Agnes M. Resto Irizarry, Norio Kobayashi, Xufeng Xue, Yue Shao, Cheng Zhao, Nicole L. Agranonik, Megan Sparrow, Timothy J. Hunt, Jared Faith, Mary Jasmine Lara, Qiu Ya Wu, Sherman Silber, Sophie Petropoulos, Ran Yang, Kenneth R. Chien, Amander T. Clark, Jianping Fu

    Published 2024-01-01
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  16. 16
    Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure

    Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure by Erwin De Genst, Kylie S. Foo, Yao Xiao, Eduarde Rohner, Emma de Vries, Jesper Sohlmér, Nevin Witman, Alejandro Hidalgo, Terje R. S. Kolstad, William E. Louch, Susanne Pehrsson, Andrew Park, Yasuhiro Ikeda, Xidan Li, Lorenz M. Mayr, Kate Wickson, Karin Jennbacken, Kenny Hansson, Regina Fritsche-Danielson, James Hunt, Kenneth R. Chien

    Published 2022-05-01
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  17. 17
    Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine

    Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine by Leif Carlsson, Jonathan C. Clarke, Christopher Yen, Francine Gregoire, Tamsin Albery, Martin Billger, Ann-Charlotte Egnell, Li-Ming Gan, Karin Jennbacken, Edvin Johansson, Gunilla Linhardt, Sofia Martinsson, Muhammad Waqas Sadiq, Nevin Witman, Qing-Dong Wang, Chien-Hsi Chen, Yu-Ping Wang, Susan Lin, Barry Ticho, Patrick C.H. Hsieh, Kenneth R. Chien, Regina Fritsche-Danielson

    Published 2018-06-01
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  18. 18
    Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

    Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells by Faye M. Drawnel, Stefano Boccardo, Michael Prummer, Frédéric Delobel, Alexandra Graff, Michael Weber, Régine Gérard, Laura Badi, Tony Kam-Thong, Lei Bu, Xin Jiang, Jean-Christophe Hoflack, Anna Kiialainen, Elena Jeworutzki, Natsuyo Aoyama, Coby Carlson, Mark Burcin, Gianni Gromo, Markus Boehringer, Henning Stahlberg, Benjamin J. Hall, Maria Chiara Magnone, Kyle Kolaja, Kenneth R. Chien, Jacques Bailly, Roberto Iacone

    Published 2014-11-01
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  19. 19
    Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy

    Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy by Niels Grote Beverborg, Daniela Später, Ralph Knöll, Alejandro Hidalgo, Steve T. Yeh, Zaher Elbeck, Herman H. W. Silljé, Tim R. Eijgenraam, Humam Siga, Magdalena Zurek, Malin Palmér, Susanne Pehrsson, Tamsin Albery, Nils Bomer, Martijn F. Hoes, Cornelis J. Boogerd, Michael Frisk, Eva van Rooij, Sagar Damle, William E. Louch, Qing-Dong Wang, Regina Fritsche-Danielson, Kenneth R. Chien, Kenny M. Hansson, Adam E. Mullick, Rudolf A. de Boer, Peter van der Meer

    Published 2021-08-01
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