Hasil Pencarian - John G Doench

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  1. 1
    Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens.

    Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens. oleh Mudra Hegde, Christine Strand, Ruth E Hanna, John G Doench

    Diterbitkan 2018-01-01
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  2. 2
    Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons.

    Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons. oleh Stefan Zdraljevic, Christine Strand, Hannah S Seidel, Daniel E Cook, John G Doench, Erik C Andersen

    Diterbitkan 2017-07-01
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  3. 3
    High-Throughput CRISPR Screens To Dissect Macrophage-Shigella Interactions

    High-Throughput CRISPR Screens To Dissect Macrophage-Shigella Interactions oleh Yong Lai, Liang Cui, Gregory H. Babunovic, Sarah M. Fortune, John G. Doench, Timothy K. Lu

    Diterbitkan 2021-12-01
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  4. 4
    Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening

    Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening oleh Peter C. DeWeirdt, Abby V. McGee, Fengyi Zheng, Ifunanya Nwolah, Mudra Hegde, John G. Doench

    Diterbitkan 2022-09-01
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  5. 5
    Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

    Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death oleh Eduardo Balsa, Elizabeth A. Perry, Christopher F. Bennett, Mark Jedrychowski, Steven P. Gygi, John G. Doench, Pere Puigserver

    Diterbitkan 2020-06-01
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  6. 6
    Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool.

    Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool. oleh Katherine F Donovan, Mudra Hegde, Meagan Sullender, Emma W Vaimberg, Cory M Johannessen, David E Root, John G Doench

    Diterbitkan 2017-01-01
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  7. 7
    Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects.

    Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects. oleh Shantanu Singh, Xiaoyun Wu, Vebjorn Ljosa, Mark-Anthony Bray, Federica Piccioni, David E Root, John G Doench, Jesse S Boehm, Anne E Carpenter

    Diterbitkan 2015-01-01
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  8. 8
    Genetic screens in isogenic mammalian cell lines without single cell cloning

    Genetic screens in isogenic mammalian cell lines without single cell cloning oleh Peter C. DeWeirdt, Annabel K. Sangree, Ruth E. Hanna, Kendall R. Sanson, Mudra Hegde, Christine Strand, Nicole S. Persky, John G. Doench

    Diterbitkan 2020-02-01
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  9. 9
    A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion

    A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion oleh Joseph S. Park, Jennifer D. Helble, Jacob E. Lazarus, Guanhua Yang, Carlos J. Blondel, John G. Doench, Michael N. Starnbach, Matthew K. Waldor

    Diterbitkan 2019-01-01
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  10. 10
    Protocol for in vivo CRISPR screening using selective CRISPR antigen removal lentiviral vectors

    Protocol for in vivo CRISPR screening using selective CRISPR antigen removal lentiviral vectors oleh Sarah Kate Lane-Reticker, Emily A. Kessler, Audrey J. Muscato, Sarah Y. Kim, John G. Doench, Kathleen B. Yates, Robert T. Manguso, Juan Dubrot

    Diterbitkan 2023-03-01
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  11. 11
    Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis

    Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis oleh Baobing Zhao, Ganesan Keerthivasan, Yang Mei, Jing Yang, James McElherne, Piu Wong, John G. Doench, Gang Feng, David E. Root, Peng Ji

    Diterbitkan 2014-07-01
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  12. 12
    CRISPR Screen Reveals that EHEC’s T3SS and Shiga Toxin Rely on Shared Host Factors for Infection

    CRISPR Screen Reveals that EHEC’s T3SS and Shiga Toxin Rely on Shared Host Factors for Infection oleh Alline R. Pacheco, Jacob E. Lazarus, Brandon Sit, Stefanie Schmieder, Wayne I. Lencer, Carlos J. Blondel, John G. Doench, Brigid M. Davis, Matthew K. Waldor

    Diterbitkan 2018-07-01
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  13. 13
    Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS

    Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS oleh Xiaojian Shi, Bryn Reinstadler, Hardik Shah, Tsz-Leung To, Katie Byrne, Luanna Summer, Sarah E. Calvo, Olga Goldberger, John G. Doench, Vamsi K. Mootha, Hongying Shen

    Diterbitkan 2022-05-01
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  14. 14
    Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform

    Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform oleh Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L. Wilson, Ryan Steger, Annabel K. Sangree, Medina Colic, Sidney H. Wang, John G. Doench, Traver Hart

    Diterbitkan 2024-04-01
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  15. 15
    Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2

    Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2 oleh Annabel K. Sangree, Audrey L. Griffith, Zsofia M. Szegletes, Priyanka Roy, Peter C. DeWeirdt, Mudra Hegde, Abby V. McGee, Ruth E. Hanna, John G. Doench

    Diterbitkan 2022-03-01
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  16. 16
    Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

    Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism oleh Stefan Zdraljevic, Bennett William Fox, Christine Strand, Oishika Panda, Francisco J Tenjo, Shannon C Brady, Tim A Crombie, John G Doench, Frank C Schroeder, Erik C Andersen

    Diterbitkan 2019-04-01
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  17. 17
    Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map.

    Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map. oleh Ian Smith, Peyton G Greenside, Ted Natoli, David L Lahr, David Wadden, Itay Tirosh, Rajiv Narayan, David E Root, Todd R Golub, Aravind Subramanian, John G Doench

    Diterbitkan 2017-11-01
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  18. 18
    Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

    Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities oleh Kendall R. Sanson, Ruth E. Hanna, Mudra Hegde, Katherine F. Donovan, Christine Strand, Meagan E. Sullender, Emma W. Vaimberg, Amy Goodale, David E. Root, Federica Piccioni, John G. Doench

    Diterbitkan 2018-12-01
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  19. 19
    Developing SHP2-based combination therapy for KRAS-amplified cancer

    Developing SHP2-based combination therapy for KRAS-amplified cancer oleh Tianxia Li, Osamu Kikuchi, Jin Zhou, Yichen Wang, Babita Pokharel, Klavdija Bastl, Prafulla Gokhale, Aine Knott, Yanxi Zhang, John G. Doench, Zandra V. Ho, Daniel V.T. Catenacci, Adam J. Bass

    Diterbitkan 2023-02-01
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  20. 20
    Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites

    Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites oleh Marina Maurizio, Maria Masid, Kerry Woods, Reto Caldelari, John G. Doench, Arunasalam Naguleswaran, Denis Joly, Martín González-Fernández, Jonas Zemp, Mélanie Borteele, Vassily Hatzimanikatis, Volker Heussler, Sven Rottenberg, Philipp Olias

    Diterbitkan 2024-07-01
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