Hasil Pencarian - Jim R. Hughes

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  1. 1
    Multi Locus View: an extensible web-based tool for the analysis of genomic data.

    Multi Locus View: an extensible web-based tool for the analysis of genomic data. oleh Martin J. Sergeant, Jim R. Hughes, Lance Hentges, Gerton Lunter, Damien J. Downes, Stephen Taylor

    Diterbitkan 2021-05-01
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  2. 2
    A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus

    A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus oleh A. Marieke Oudelaar, Caroline L. Harrold, Lars L. P. Hanssen, Jelena M. Telenius, Douglas R. Higgs, Jim R. Hughes

    Diterbitkan 2019-11-01
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  3. 3
    Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells.

    Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells. oleh Ioanna Pavlaki, Michael Shapiro, Giuseppina Pisignano, Stephanie M E Jones, Jelena Telenius, Silvia Muñoz-Descalzo, Robert J Williams, Jim R Hughes, Keith W Vance

    Diterbitkan 2022-06-01
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  4. 4
    Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells

    Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells oleh Ioanna Pavlaki, Michael Shapiro, Giuseppina Pisignano, Stephanie M. E. Jones, Jelena Telenius, Silvia Muñoz-Descalzo, Robert J. Williams, Jim R. Hughes, Keith W. Vance

    Diterbitkan 2022-06-01
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  5. 5
    Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells [version 2; peer review: 2 approved]

    Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells [version 2; peer review: 2 approved] oleh Jason M. Torres, Vibe Nylander, Han Sun, Martijn van de Bunt, Damien J. Downes, Mark I. McCarthy, Jim R. Hughes, Anna L. Gloyn

    Diterbitkan 2023-08-01
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  6. 6
    Causes and consequences of chromatin variation between inbred mice.

    Causes and consequences of chromatin variation between inbred mice. oleh Mona Hosseini, Leo Goodstadt, Jim R Hughes, Monika S Kowalczyk, Marco de Gobbi, Georg W Otto, Richard R Copley, Richard Mott, Douglas R Higgs, Jonathan Flint

    Diterbitkan 2013-06-01
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  7. 7
    ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes

    ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes oleh Hsiao P.J. Voon, Jim R. Hughes, Christina Rode, Inti A. De La Rosa-Velázquez, Thomas Jenuwein, Robert Feil, Douglas R. Higgs, Richard J. Gibbons

    Diterbitkan 2015-04-01
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  8. 8
    A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker

    A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker oleh Yavor K. Bozhilov, Damien J. Downes, Jelena Telenius, A. Marieke Oudelaar, Emmanuel N. Olivier, Joanne C. Mountford, Jim R. Hughes, Richard J. Gibbons, Douglas R. Higgs

    Diterbitkan 2021-06-01
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  9. 9
    The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin

    The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin oleh Julia Truch, Damien J. Downes, Caroline Scott, E. Ravza Gür, Jelena M. Telenius, Emmanouela Repapi, Ron Schwessinger, Matthew Gosden, Jill M. Brown, Stephen Taylor, Pak Leng Cheong, Jim R. Hughes, Douglas R. Higgs, Richard J. Gibbons

    Diterbitkan 2022-06-01
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  10. 10
    DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

    DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation oleh Laura Godfrey, Nicholas T. Crump, Ross Thorne, I-Jun Lau, Emmanouela Repapi, Dimitra Dimou, Alastair L. Smith, Joe R. Harman, Jelena M. Telenius, A. Marieke Oudelaar, Damien J. Downes, Paresh Vyas, Jim R. Hughes, Thomas A. Milne

    Diterbitkan 2019-06-01
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  11. 11
    Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development

    Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development oleh Dominic D. G. Owens, Giorgio Anselmi, A. Marieke Oudelaar, Damien J. Downes, Alessandro Cavallo, Joe R. Harman, Ron Schwessinger, Akin Bucakci, Lucas Greder, Sara de Ornellas, Danuta Jeziorska, Jelena Telenius, Jim R. Hughes, Marella F. T. R. de Bruijn

    Diterbitkan 2022-02-01
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  12. 12
    A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions

    A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions oleh Jill M. Brown, Nigel A. Roberts, Bryony Graham, Dominic Waithe, Christoffer Lagerholm, Jelena M. Telenius, Sara De Ornellas, A. Marieke Oudelaar, Caroline Scott, Izabela Szczerbal, Christian Babbs, Mira T. Kassouf, Jim R. Hughes, Douglas R. Higgs, Veronica J. Buckle

    Diterbitkan 2018-09-01
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  13. 13
    Dynamics of the 4D genome during in vivo lineage specification and differentiation

    Dynamics of the 4D genome during in vivo lineage specification and differentiation oleh A. Marieke Oudelaar, Robert A. Beagrie, Matthew Gosden, Sara de Ornellas, Emily Georgiades, Jon Kerry, Daniel Hidalgo, Joana Carrelha, Arun Shivalingam, Afaf H. El-Sagheer, Jelena M. Telenius, Tom Brown, Veronica J. Buckle, Merav Socolovsky, Douglas R. Higgs, Jim R. Hughes

    Diterbitkan 2020-06-01
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  14. 14
    A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells

    A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells oleh Andrea M. Chiariello, Simona Bianco, A. Marieke Oudelaar, Andrea Esposito, Carlo Annunziatella, Luca Fiorillo, Mattia Conte, Alfonso Corrado, Antonella Prisco, Martin S.C. Larke, Jelena M. Telenius, Renato Sciarretta, Francesco Musella, Veronica J. Buckle, Douglas R. Higgs, Jim R. Hughes, Mario Nicodemi

    Diterbitkan 2020-02-01
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  15. 15
    High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

    High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale oleh Damien J. Downes, Robert A. Beagrie, Matthew E. Gosden, Jelena Telenius, Stephanie J. Carpenter, Lea Nussbaum, Sara De Ornellas, Martin Sergeant, Chris Q. Eijsbouts, Ron Schwessinger, Jon Kerry, Nigel Roberts, Arun Shivalingam, Afaf El-Sagheer, A. Marieke Oudelaar, Tom Brown, Veronica J. Buckle, James O. J. Davies, Jim R. Hughes

    Diterbitkan 2021-01-01
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  16. 16
    Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia

    Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia oleh Sachith Mettananda, Chris A. Fisher, Deborah Hay, Mohsin Badat, Lynn Quek, Kevin Clark, Philip Hublitz, Damien Downes, Jon Kerry, Matthew Gosden, Jelena Telenius, Jackie A. Sloane-Stanley, Paula Faustino, Andreia Coelho, Jessica Doondeea, Batchimeg Usukhbayar, Paul Sopp, Jacqueline A. Sharpe, Jim R. Hughes, Paresh Vyas, Richard J. Gibbons, Douglas R. Higgs

    Diterbitkan 2017-09-01
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  17. 17
    Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

    Hepcidin is regulated by promoter-associated histone acetylation and HDAC3 oleh Sant-Rayn Pasricha, Pei Jin Lim, Tiago L. Duarte, Carla Casu, Dorenda Oosterhuis, Katarzyna Mleczko-Sanecka, Maria Suciu, Ana Rita Da Silva, Kinda Al-Hourani, João Arezes, Kirsty McHugh, Sarah Gooding, Joe N. Frost, Katherine Wray, Ana Santos, Graça Porto, Emmanouela Repapi, Nicki Gray, Simon J. Draper, Neil Ashley, Elizabeth Soilleux, Peter Olinga, Martina U. Muckenthaler, Jim R. Hughes, Stefano Rivella, Thomas A. Milne, Andrew E. Armitage, Hal Drakesmith

    Diterbitkan 2017-09-01
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  18. 18
    HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

    HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis oleh TingDong Yan, Wen Fong Ooi, Aditi Qamra, Alice Cheung, DongLiang Ma, Gopinath Meenakshi Sundaram, Chang Xu, Manjie Xing, LaiFong Poon, Jing Wang, Yan Ping Loh, Jess Hui Jie Ho, Joscelyn Jun Quan Ng, Muhammad Khairul Ramlee, Luay Aswad, Steve G. Rozen, Sujoy Ghosh, Frederic A. Bard, Prabha Sampath, Vinay Tergaonkar, James O. J. Davies, Jim R. Hughes, Eyleen Goh, Xuezhi Bi, Melissa Jane Fullwood, Patrick Tan, Shang Li

    Diterbitkan 2018-01-01
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  19. 19
    Reactivation of a developmentally silenced embryonic globin gene

    Reactivation of a developmentally silenced embryonic globin gene oleh Andrew J. King, Duantida Songdej, Damien J. Downes, Robert A. Beagrie, Siyu Liu, Megan Buckley, Peng Hua, Maria C. Suciu, A. Marieke Oudelaar, Lars L. P. Hanssen, Danuta Jeziorska, Nigel Roberts, Stephanie J. Carpenter, Helena Francis, Jelena Telenius, Aude-Anais Olijnik, Jacqueline A. Sharpe, Jacqueline Sloane-Stanley, Jennifer Eglinton, Mira T. Kassouf, Stuart H. Orkin, Len A. Pennacchio, James O. J. Davies, Jim R. Hughes, Douglas R. Higgs, Christian Babbs

    Diterbitkan 2021-07-01
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  20. 20
    Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity

    Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity oleh Wen Fong Ooi, Manjie Xing, Chang Xu, Xiaosai Yao, Muhammad Khairul Ramlee, Mei Chee Lim, Fan Cao, Kevin Lim, Deepak Babu, Lai-Fong Poon, Joyce Lin Suling, Aditi Qamra, Astrid Irwanto, James Qu Zhengzhong, Tannistha Nandi, Ai Ping Lee-Lim, Yang Sun Chan, Su Ting Tay, Ming Hui Lee, James O. J. Davies, Wai Keong Wong, Khee Chee Soo, Weng Hoong Chan, Hock Soo Ong, Pierce Chow, Chow Yin Wong, Sun Young Rha, Jianjun Liu, Axel M. Hillmer, Jim R. Hughes, Steve Rozen, Bin Tean Teh, Melissa Jane Fullwood, Shang Li, Patrick Tan

    Diterbitkan 2016-09-01
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