Hasil Pencarian - Jason E. Gestwicki

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  1. 1
    Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks

    Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks oleh Laura C Cesa, Anna K Mapp, Jason E Gestwicki

    Diterbitkan 2015-08-01
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  2. 2
    Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells

    Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells oleh Seung-Keun Hong, Dmytro Starenki, Oleta T. Johnson, Jason E. Gestwicki, Jong-In Park

    Diterbitkan 2022-01-01
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  3. 3
    Identification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaK.

    Identification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaK. oleh Peter Man-Un Ung, Andrea D Thompson, Lyra Chang, Jason E Gestwicki, Heather A Carlson

    Diterbitkan 2013-01-01
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  4. 4
    The YΦ motif defines the structure-activity relationships of human 20S proteasome activators

    The YΦ motif defines the structure-activity relationships of human 20S proteasome activators oleh Kwadwo A. Opoku-Nsiah, Andres H. de la Pena, Sarah K. Williams, Nikita Chopra, Andrej Sali, Gabriel C. Lander, Jason E. Gestwicki

    Diterbitkan 2022-03-01
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  5. 5
    Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

    Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau oleh Rebecca Freilich, Miguel Betegon, Eric Tse, Sue-Ann Mok, Olivier Julien, David A. Agard, Daniel R. Southworth, Koh Takeuchi, Jason E. Gestwicki

    Diterbitkan 2018-11-01
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  6. 6
    Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate

    Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate oleh Daniel C. Carrettiero, Maria C. Almeida, Andrew P. Longhini, Jennifer N. Rauch, Dasol Han, Xuemei Zhang, Saeed Najafi, Jason E. Gestwicki, Kenneth S. Kosik

    Diterbitkan 2022-06-01
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  7. 7
    Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models

    Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models oleh Pengfei Xu, Joy C. Yang, Shu Ning, Bo Chen, Christopher Nip, Qiang Wei, Liangren Liu, Oleta T. Johnson, Allen C. Gao, Jason E. Gestwicki, Christopher P. Evans, Chengfei Liu

    Diterbitkan 2023-03-01
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  8. 8
    Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP

    Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP oleh Cory M. Nadel, Saugat Pokhrel, Kristin Wucherer, Abby Oehler, Aye C. Thwin, Koli Basu, Matthew D. Callahan, Daniel R. Southworth, Daniel A. Mordes, Charles S. Craik, Jason E. Gestwicki

    Diterbitkan 2024-09-01
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  9. 9
    Correction: Rhodacyanine Derivative Selectively Targets Cancer Cells and Overcomes Tamoxifen Resistance.

    Correction: Rhodacyanine Derivative Selectively Targets Cancer Cells and Overcomes Tamoxifen Resistance. oleh John Koren, Yoshinari Miyata, Janine Kiray, John C. O'Leary, Lana Nguyen, Jianping Guo, Laura J. Blair, Xiaokai Li, Umesh K. Jinwal, Jin Q. Cheng, Jason E. Gestwicki, Chad A. Dickey

    Diterbitkan 2012-01-01
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  10. 10
    Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance.

    Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. oleh John Koren, Yoshinari Miyata, Janine Kiray, John C O'Leary, Lana Nguyen, Jianping Guo, Laura J Blair, Xiaokai Li, Umesh K Jinwal, Jin Q Cheng, Jason E Gestwicki, Chad A Dickey

    Diterbitkan 2012-01-01
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  11. 11
    Predicting protein targets for drug-like compounds using transcriptomics.

    Predicting protein targets for drug-like compounds using transcriptomics. oleh Nicolas A Pabon, Yan Xia, Samuel K Estabrooks, Zhaofeng Ye, Amanda K Herbrand, Evelyn Süß, Ricardo M Biondi, Victoria A Assimon, Jason E Gestwicki, Jeffrey L Brodsky, Carlos J Camacho, Ziv Bar-Joseph

    Diterbitkan 2018-12-01
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  12. 12
    A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystrophy in rats

    A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystrophy in rats oleh Miyuu Tanaka, Miyuu Tanaka, Ryoko Fujikawa, Takahiro Sekiguchi, Jason Hernandez, Oleta T. Johnson, Daisuke Tanaka, Kenta Kumafuji, Tadao Serikawa, Hieu Hoang Trung, Kosuke Hattori, Tomoji Mashimo, Mitsuru Kuwamura, Jason E. Gestwicki, Takashi Kuramoto, Takashi Kuramoto

    Diterbitkan 2024-02-01
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  13. 13
    Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy

    Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy oleh Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Michelle Arkin, Ana Maria Cuervo, Li Gan

    Diterbitkan 2020-01-01
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  14. 14
    Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

    Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy oleh Chao Wang, Li Fan, Rabia R. Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Sue-Ann Mok, Jason E. Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan

    Diterbitkan 2022-04-01
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  15. 15
    Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer

    Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer oleh Pengfei Xu, Joy C. Yang, Bo Chen, Shu Ning, Xiong Zhang, Leyi Wang, Christopher Nip, Yuqiu Shen, Oleta T. Johnson, Gabriela Grigorean, Brett Phinney, Liangren Liu, Qiang Wei, Eva Corey, Clifford G. Tepper, Hong-Wu Chen, Christopher P. Evans, Marc A. Dall’Era, Allen C. Gao, Jason E. Gestwicki, Chengfei Liu

    Diterbitkan 2024-08-01
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  16. 16
    Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

    Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice oleh Benjamin Caballero, Mathieu Bourdenx, Enrique Luengo, Antonio Diaz, Peter Dongmin Sohn, Xu Chen, Chao Wang, Yves R. Juste, Susanne Wegmann, Bindi Patel, Zapporah T. Young, Szu Yu Kuo, Jose Antonio Rodriguez-Navarro, Hao Shao, Manuela G. Lopez, Celeste M. Karch, Alison M. Goate, Jason E. Gestwicki, Bradley T. Hyman, Li Gan, Ana Maria Cuervo

    Diterbitkan 2021-04-01
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  17. 17
    Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor

    Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor oleh Bahareh Eftekharzadeh, Varuna C. Banduseela, Giulio Chiesa, Paula Martínez-Cristóbal, Jennifer N. Rauch, Samir R. Nath, Daniel M. C. Schwarz, Hao Shao, Marta Marin-Argany, Claudio Di Sanza, Elisa Giorgetti, Zhigang Yu, Roberta Pierattelli, Isabella C. Felli, Isabelle Brun-Heath, Jesús García, Ángel R. Nebreda, Jason E. Gestwicki, Andrew P. Lieberman, Xavier Salvatella

    Diterbitkan 2019-08-01
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  18. 18
    Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor

    Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor oleh Bahareh Eftekharzadeh, Varuna C. Banduseela, Giulio Chiesa, Paula Martínez-Cristóbal, Jennifer N. Rauch, Samir R. Nath, Daniel M. C. Schwarz, Hao Shao, Marta Marin-Argany, Claudio Di Sanza, Elisa Giorgetti, Zhigang Yu, Roberta Pierattelli, Isabella C. Felli, Isabelle Brun-Heath, Jesús García, Ángel R. Nebreda, Jason E. Gestwicki, Andrew P. Lieberman, Xavier Salvatella

    Diterbitkan 2019-10-01
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  19. 19
    Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

    Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates oleh Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn-Moron, Claudia Fontsere, Merve Ceylan, Megan L. Koleske, Niklas Handin, Virginia M. Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur Zalevsky, Andrej Sali, Colin M. Brand, Finn D. Wolfreys, Jia Yang, Jason E. Gestwicki, John A. Capra, Per Artursson, John W. Newman, Tomàs Marquès-Bonet, Kathleen M. Giacomini

    Diterbitkan 2024-05-01
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  20. 20
    Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks

    Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks oleh Melanie Meister-Broekema, Rebecca Freilich, Chandhuru Jagadeesan, Jennifer N. Rauch, Rocio Bengoechea, William W. Motley, E. F. Elsiena Kuiper, Melania Minoia, Gabriel V. Furtado, Maria A. W. H. van Waarde, Shawn J. Bird, Adriana Rebelo, Stephan Zuchner, Peter Pytel, Steven S. Scherer, Federica F. Morelli, Serena Carra, Conrad C. Weihl, Steven Bergink, Jason E. Gestwicki, Harm H. Kampinga

    Diterbitkan 2018-12-01
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