CRISPR/Cas9 nickase mediated signal amplification integrating with the trans-cleavage activity of Cas12a for highly selective and sensitive detection of single base mutations oleh Xiao-Wen Fan, Zi-Fan Gao, Dong-Dong Ling, De-Hui Wang, Ying Cui, Hui-Qun Du, Chun-Lin Li, Xing Zhou