MET Suppresses Epithelial VEGFR2 via Intracrine VEGF-induced Endoplasmic Reticulum-associated Degradation by Tom T. Chen, Ellen Filvaroff, Jing Peng, Scot Marsters, Adrian Jubb, Hartmut Koeppen, Mark Merchant, Avi Ashkenazi

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High cell-surface density of HER2 deforms cell membranes by Inhee Chung, Mike Reichelt, Lily Shao, Robert W. Akita, Hartmut Koeppen, Linda Rangell, Gabriele Schaefer, Ira Mellman, Mark X. Sliwkowski

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MET gene copy number alterations and expression of MET and hepatocyte growth factor are potential biomarkers in angiosarcomas and undifferentiated pleomorphic sarcomas. by Katja Schmitz, Hartmut Koeppen, Elke Binot, Jana Fassunke, Helen Künstlinger, Michaela A Ihle, Carina Heydt, Eva Wardelmann, Reinhard Büttner, Sabine Merkelbach-Bruse, Josef Rüschoff, Hans-Ulrich Schildhaus

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TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma. by Kui Lin, James R Taylor, Thomas D Wu, Johnny Gutierrez, J Michael Elliott, Jean-Michel Vernes, Hartmut Koeppen, Heidi S Phillips, Frederic J de Sauvage, Y Gloria Meng

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601 Identification of non-squamous NSCLC molecular subtypes and association with outcomes in the phase 3 IMpower150 study of 1L atezolizumab ± bevacizumab + carboplatin-paclitaxel... by Aditi Qamra, Hartmut Koeppen, Fabrice Barlesi, Federico Cappuzzo, Martin Reck, Mark A Socinski, Marcus Ballinger, Robert M Jotte, Barzin Nabet, Minu K Srivastava, Soren Muller, Tianshi Lu, Howard West, Habib Hamidi, Assaf Amitai, David S Shames

Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers. by Erica B Schleifman, Rupal Desai, Jill M Spoerke, Yuanyuan Xiao, Cheryl Wong, Ilma Abbas, Carol O'Brien, Rajesh Patel, Teiko Sumiyoshi, Ling Fu, Rachel N Tam, Hartmut Koeppen, Timothy R Wilson, Rajiv Raja, Garret M Hampton, Mark R Lackner

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Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α by Adrien Le Thomas, Elena Ferri, Scot Marsters, Jonathan M. Harnoss, David A. Lawrence, Iratxe Zuazo-Gaztelu, Zora Modrusan, Sara Chan, Margaret Solon, Cécile Chalouni, Weihan Li, Hartmut Koeppen, Joachim Rudolph, Weiru Wang, Thomas D. Wu, Peter Walter, Avi Ashkenazi

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Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer by Mélanie Desbois, Akshata R. Udyavar, Lisa Ryner, Cleopatra Kozlowski, Yinghui Guan, Milena Dürrbaum, Shan Lu, Jean-Philippe Fortin, Hartmut Koeppen, James Ziai, Ching-Wei Chang, Shilpa Keerthivasan, Marie Plante, Richard Bourgon, Carlos Bais, Priti Hegde, Anneleen Daemen, Shannon Turley, Yulei Wang

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Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice by Janet Lau, Jeanne Cheung, Armando Navarro, Steve Lianoglou, Benjamin Haley, Klara Totpal, Laura Sanders, Hartmut Koeppen, Patrick Caplazi, Jacqueline McBride, Henry Chiu, Rebecca Hong, Jane Grogan, Vincent Javinal, Robert Yauch, Bryan Irving, Marcia Belvin, Ira Mellman, Jeong M. Kim, Maike Schmidt

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606 IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab or chemotherapy by Robert Johnston, Hartmut Koeppen, Roy S Herbst, Kurt Schalper, Filippo De Marinis, Giuseppe Giaccone, Jacek Jassem, Marcus Ballinger, Barani Kumar Rajendran, David R Spigel, Miguel López de Rodas, Minu K Srivastava, Jennifer M Giltnane, Barzin Y Nabet, David S Shames, Velimir Gayevskiy, Vy Ma, Ivette Estay, Tien Hoang, Reena Amin

Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma by Jeffrey J. Wallin, Johanna C. Bendell, Roel Funke, Mario Sznol, Konstanty Korski, Suzanne Jones, Genevive Hernandez, James Mier, Xian He, F. Stephen Hodi, Mitchell Denker, Vincent Leveque, Marta Cañamero, Galina Babitski, Hartmut Koeppen, James Ziai, Neeraj Sharma, Fabien Gaire, Daniel S. Chen, Daniel Waterkamp, Priti S. Hegde, David F. McDermott

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Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors by Kristin M. Zimmerman Savill, Brian B. Lee, Jason Oeh, Jie Lin, Eva Lin, Wei-Jen Chung, Amy Young, Wennie Chen, Monika Miś, Kathryn Mesh, Jeffrey Eastham, Florian Gnad, Zhaoshi Jiang, Eric W. Stawiski, Benjamin Haley, Anneleen Daemen, Xiaojing Wang, Hartmut Koeppen, Zora Modrusan, Scott E. Martin, Deepak Sampath, Kui Lin

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Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors. by Mark Merchant, John Moffat, Gabriele Schaefer, Jocelyn Chan, Xi Wang, Christine Orr, Jason Cheng, Thomas Hunsaker, Lily Shao, Stephanie J Wang, Marie-Claire Wagle, Eva Lin, Peter M Haverty, Sheerin Shahidi-Latham, Hai Ngu, Margaret Solon, Jeffrey Eastham-Anderson, Hartmut Koeppen, Shih-Min A Huang, Jacob Schwarz, Marcia Belvin, Daniel Kirouac, Melissa R Junttila

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Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors. by Mark Merchant, John Moffat, Gabriele Schaefer, Jocelyn Chan, Xi Wang, Christine Orr, Jason Cheng, Thomas Hunsaker, Lily Shao, Stephanie J Wang, Marie-Claire Wagle, Eva Lin, Peter M Haverty, Sheerin Shahidi-Latham, Hai Ngu, Margaret Solon, Jeffrey Eastham-Anderson, Hartmut Koeppen, Shih-Min A Huang, Jacob Schwarz, Marcia Belvin, Daniel Kirouac, Melissa R Junttila

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CEA-CD3 bispecific antibody cibisatamab with or without atezolizumab in patients with CEA-positive solid tumours: results of two multi-institutional Phase 1 trials by Neil H. Segal, Ignacio Melero, Victor Moreno, Neeltje Steeghs, Aurelien Marabelle, Kristoffer Rohrberg, Maria E. Rodriguez-Ruiz, Joseph P. Eder, Cathy Eng, Gulam A. Manji, Daniel Waterkamp, Barbara Leutgeb, Said Bouseida, Nick Flinn, Meghna Das Thakur, Markus C. Elze, Hartmut Koeppen, Candice Jamois, Meret Martin-Facklam, Christopher H. Lieu, Emiliano Calvo, Luis Paz-Ares, Josep Tabernero, Guillem Argilés

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Multimodal Microvascular Imaging Reveals that Selective Inhibition of Class I PI3K Is Sufficient to Induce an Antivascular Response by Deepak Sampath, Jason Oeh, Shelby K. Wyatt, Tim C. Cao, Hartmut Koeppen, Jeffrey Eastham-Anderson, Liliane Robillard, Calvin C.K. Ho, Jed Ross, Guanglei Zhuang, Hani Bou Reslan, Philip Vitorino, Kai H. Barck, Sharon E. Ungersma, Jean Michel Vernes, Maresa Caunt, Nick Van Bruggen, Weilan Ye, Ulka Vijapurkar, Yu-Ju Gloria Meng, Napoleone Ferrara, Lori S. Friedman, Richard A.D. Carano

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Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers by Jennifer Cantley, Xiaofen Ye, Emma Rousseau, Tom Januario, Brian D. Hamman, Christopher M. Rose, Tommy K. Cheung, Trent Hinkle, Leofal Soto, Connor Quinn, Alicia Harbin, Elizabeth Bortolon, Xin Chen, Roy Haskell, Eva Lin, Shang-Fan Yu, Geoff Del Rosario, Emily Chan, Debra Dunlap, Hartmut Koeppen, Scott Martin, Mark Merchant, Matt Grimmer, Fabio Broccatelli, Jing Wang, Jennifer Pizzano, Peter S. Dragovich, Michael Berlin, Robert L. Yauch

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Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade by Marcin Kowanetz, Thomas Powles, Hartmut Koeppen, Jane Grogan, Patrick Caplazi, Ira Mellman, Wei Zou, Sanjeev Mariathasan, Priti S. Hegde, Mark McCleland, Jacqueline McBride, Zora Modrusan, Romain Banchereau, Avantika S. Chitre, Alexis Scherl, Thomas D. Wu, Namrata S. Patil, Patricia de Almeida, Edward E. Kadel, III, Shravan Madireddi, Amelia Au-Yeung, Chikara Takahashi, Ying-Jiun Chen, Rhea Nersesian, Ehab A. El-Gabry, Mark D. Robida, Jeffrey C. Hung, Shadi Toghi Eshgi, W. Rodney Mathews, William E O'Gorman

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