Pan-resistant HIV-1 emergence in the era of integrase strand-transfer inhibitors: a case report oleh Maria C Puertas, PhD, George Ploumidis, MD, Michalis Ploumidis, MD, Emilio Fumero, MD, Bonaventura Clotet, MD, Charles M Walworth, MD, Christos J Petropoulos, PhD, Javier Martinez-Picado, PhD