Hasil Pencarian - Geert Jan Groeneveld

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  1. 1
    Analgesic drug development: proof-of-mechanism and proof-of-concept in early phase clinical studies

    Analgesic drug development: proof-of-mechanism and proof-of-concept in early phase clinical studies oleh Hemme J. Hijma, MSc, Geert Jan Groeneveld, MD, PhD

    Diterbitkan 2021-06-01
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  2. 2
    Inflammatory plasma biomarkers in subjects with preclinical Alzheimer’s disease

    Inflammatory plasma biomarkers in subjects with preclinical Alzheimer’s disease oleh Samantha Prins, Marieke L. de Kam, Charlotte E. Teunissen, Geert Jan Groeneveld

    Diterbitkan 2022-08-01
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  3. 3
    A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly selective Nav1.8 inhibitor, in healthy adults

    A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly... oleh Hemme J. Hijma, Emilie M. J. vanBrummelen, Pieter S. Siebenga, Geert Jan Groeneveld

    Diterbitkan 2022-04-01
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  4. 4
    A cross-sectional study in healthy elderly subjects aimed at development of an algorithm to increase identification of Alzheimer pathology for the purpose of clinical trial participation

    A cross-sectional study in healthy elderly subjects aimed at development of an algorithm to increase identification of Alzheimer pathology for the purpose of clinical trial partici... oleh Samantha Prins, Ahnjili Zhuparris, Ellen P. Hart, Robert-Jan Doll, Geert Jan Groeneveld

    Diterbitkan 2021-07-01
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  5. 5
    Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders

    Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders oleh Maurits F. J. M. Vissers, Jules A. A. C. Heuberger, Geert Jan Groeneveld

    Diterbitkan 2021-02-01
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  6. 6
    Integration of healthy volunteers in early phase clinical trials with immuno-oncological compounds

    Integration of healthy volunteers in early phase clinical trials with immuno-oncological compounds oleh Igor Radanovic, Igor Radanovic, Naomi Klarenbeek, Robert Rissmann, Robert Rissmann, Geert Jan Groeneveld, Geert Jan Groeneveld, Emilie M. J. van Brummelen, Matthijs Moerland, Matthijs Moerland, Jacobus J. Bosch, Jacobus J. Bosch

    Diterbitkan 2022-08-01
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  7. 7
    Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Nav1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects

    Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Nav1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects oleh Pieter Siebenga, Guido vanAmerongen, Justin L. Hay, Aoibhinn McDonnell, Donal Gorman, Richard Butt, Geert Jan Groeneveld

    Diterbitkan 2020-03-01
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  8. 8
    Machine Learning Techniques for Developing Remotely Monitored Central Nervous System Biomarkers Using Wearable Sensors: A Narrative Literature Review

    Machine Learning Techniques for Developing Remotely Monitored Central Nervous System Biomarkers Using Wearable Sensors: A Narrative Literature Review oleh Ahnjili ZhuParris, Annika A. de Goede, Iris E. Yocarini, Wessel Kraaij, Geert Jan Groeneveld, Robert Jan Doll

    Diterbitkan 2023-05-01
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  9. 9
    False negatives in GBA1 sequencing due to polymerase dependent allelic imbalance

    False negatives in GBA1 sequencing due to polymerase dependent allelic imbalance oleh Jonas M. den Heijer, Arnoud Schmitz, Peter Lansbury, Valerie C. Cullen, Dana C. Hilt, Vincenzo Bonifati, Geert Jan Groeneveld

    Diterbitkan 2021-01-01
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  10. 10
    Muscle velocity recovery cycles as pharmacodynamic biomarker: Effects of mexiletine in a randomized double‐blind placebo‐controlled cross‐over study

    Muscle velocity recovery cycles as pharmacodynamic biomarker: Effects of mexiletine in a randomized double‐blind placebo‐controlled cross‐over study oleh Titia Q. Ruijs, Ingrid W. Koopmans, Marieke L. deKam, Martijn R. Tannemaat, Geert Jan Groeneveld, Jules A. A. C. Heuberger

    Diterbitkan 2022-12-01
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  11. 11
    Clinical trial evaluating apomorphine oromucosal solution in Parkinson's disease patients

    Clinical trial evaluating apomorphine oromucosal solution in Parkinson's disease patients oleh Eva Thijssen, Bert Tuk, Michel Cakici, Veerle vanVelze, Erica Klaassen, Frans Merkus, Teus vanLaar, Philip Kremer, Geert Jan Groeneveld

    Diterbitkan 2024-05-01
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  12. 12
    Objective Monitoring of Facioscapulohumeral Dystrophy During Clinical Trials Using a Smartphone App and Wearables: Observational Study

    Objective Monitoring of Facioscapulohumeral Dystrophy During Clinical Trials Using a Smartphone App and Wearables: Observational Study oleh Ghobad Maleki, Ahnjili Zhuparris, Ingrid Koopmans, Robert J Doll, Nicoline Voet, Adam Cohen, Emilie van Brummelen, Geert Jan Groeneveld, Joris De Maeyer

    Diterbitkan 2022-09-01
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  13. 13
    EEG machine learning for accurate detection of cholinergic intervention and Alzheimer’s disease

    EEG machine learning for accurate detection of cholinergic intervention and Alzheimer’s disease oleh Sonja Simpraga, Ricardo Alvarez-Jimenez, Huibert D. Mansvelder, Joop M. A. van Gerven, Geert Jan Groeneveld, Simon-Shlomo Poil, Klaus Linkenkaer-Hansen

    Diterbitkan 2017-07-01
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  14. 14
    First‐in‐human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS‐penetrant soluble guanylyl cyclase stimulator

    First‐in‐human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS‐penetrant soluble guanylyl cyclase stimulator oleh Sebastiaan J. W. vanKraaij, Pim Gal, Laura G. J. M. Borghans, Erica S. Klaassen, Francis Dijkstra, Christopher Winrow, Chad Glasser, Geert Jan Groeneveld

    Diterbitkan 2023-08-01
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  15. 15
    A leucine‐rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls

    A leucine‐rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls oleh Maurits F. J. M. Vissers, Matthew D. Troyer, Eva Thijssen, Diana R. Pereira, | Jules A. A. C. Heuberger, Geert Jan Groeneveld, Sarah Huntwork‐Rodriguez

    Diterbitkan 2023-08-01
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  16. 16
    The interactive walkway provides fit‐for‐purpose fall‐risk biomarkers in the elderly: Comparison of zolpidem and suvorexant

    The interactive walkway provides fit‐for‐purpose fall‐risk biomarkers in the elderly: Comparison of zolpidem and suvorexant oleh Ingrid Koopmans, Daphne Geerse, Lara deRidder, Melvyn Roerdink, Maria Joanna Juachon, Clemens Muehlan, Jasper Dingemanse, Joop vanGerven, Geert Jan Groeneveld, Rob Zuiker

    Diterbitkan 2024-07-01
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  17. 17
    Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine

    Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine oleh Charlotte Bakker, Jasper van derAart, Ellen P. Hart, Erica S. Klaassen, Kirsten R. Bergmann, Michiel J. vanEsdonk, Denis G. Kay, Geert Jan Groeneveld

    Diterbitkan 2020-01-01
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  18. 18
    Smartphone and Wearable Sensors for the Estimation of Facioscapulohumeral Muscular Dystrophy Disease Severity: Cross-sectional Study

    Smartphone and Wearable Sensors for the Estimation of Facioscapulohumeral Muscular Dystrophy Disease Severity: Cross-sectional Study oleh Ahnjili Zhuparris, Ghobad Maleki, Ingrid Koopmans, Robert J Doll, Nicoline Voet, Wessel Kraaij, Adam Cohen, Emilie van Brummelen, Joris H De Maeyer, Geert Jan Groeneveld

    Diterbitkan 2023-03-01
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  19. 19
    Randomized, placebo‐controlled study on the effects of intravenous GSK3858279 (anti‐CCL17) on a battery of evoked pain tests in healthy participants

    Randomized, placebo‐controlled study on the effects of intravenous GSK3858279 (anti‐CCL17) on a battery of evoked pain tests in healthy participants oleh Yvonne Boyle, Hemme J. Hijma, Jamie Rees, Jagtar Nijjar, Eirini Panoilia, Yolanda Alvarez, Sarah Siederer, Emma Greening, Edward Emery, Kathy Abbott Banner, Geert Jan Groeneveld

    Diterbitkan 2024-09-01
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  20. 20
    Kinetics of myelin breakdown products: A labeling study in patients with progressive multiple sclerosis

    Kinetics of myelin breakdown products: A labeling study in patients with progressive multiple sclerosis oleh Kawita M. S. Kanhai, Sebastiaan C. Goulooze, Jeroen van derGrond, Amy C. Harms, Thomas Hankemeier, Ajay Verma, Gersham Dent, Juan Chavez, Henri Meijering, Geert Jan Groeneveld

    Diterbitkan 2022-03-01
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