Hasil Pencarian - Gabriel Helmlinger

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  1. 1
    A mechanistic tumor penetration model to guide antibody drug conjugate design.

    A mechanistic tumor penetration model to guide antibody drug conjugate design. oleh Christina Vasalou, Gabriel Helmlinger, Bruce Gomes

    Diterbitkan 2015-01-01
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  2. 2
    A Generic Mechanism for Enhanced Cytokine Signaling via Cytokine-Neutralizing Antibodies.

    A Generic Mechanism for Enhanced Cytokine Signaling via Cytokine-Neutralizing Antibodies. oleh Boris Shulgin, Gabriel Helmlinger, Yuri Kosinsky

    Diterbitkan 2016-01-01
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  3. 3
    Interpretation of metabolic memory phenomenon using a physiological systems model: What drives oxidative stress following glucose normalization?

    Interpretation of metabolic memory phenomenon using a physiological systems model: What drives oxidative stress following glucose normalization? oleh Veronika Voronova, Kirill Zhudenkov, Gabriel Helmlinger, Kirill Peskov

    Diterbitkan 2017-01-01
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  4. 4
    Role of T Cell-To-Dendritic Cell Chemoattraction in T Cell Priming Initiation in the Lymph Node: An Agent-Based Modeling Study

    Role of T Cell-To-Dendritic Cell Chemoattraction in T Cell Priming Initiation in the Lymph Node: An Agent-Based Modeling Study oleh Ivan Azarov, Kirill Peskov, Kirill Peskov, Gabriel Helmlinger, Yuri Kosinsky

    Diterbitkan 2019-06-01
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  5. 5
    Quantification of Scheduling Impact on Safety and Efficacy Outcomes of Brain Metastasis Radio- and Immuno-Therapies: A Systematic Review and Meta-Analysis

    Quantification of Scheduling Impact on Safety and Efficacy Outcomes of Brain Metastasis Radio- and Immuno-Therapies: A Systematic Review and Meta-Analysis oleh Veronika Voronova, Svetlana Lebedeva, Marina Sekacheva, Gabriel Helmlinger, Kirill Peskov, Kirill Peskov

    Diterbitkan 2020-09-01
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  6. 6
    A workflow for the joint modeling of longitudinal and event data in the development of therapeutics: Tools, statistical methods, and diagnostics

    A workflow for the joint modeling of longitudinal and event data in the development of therapeutics: Tools, statistical methods, and diagnostics oleh Kirill Zhudenkov, Sergey Gavrilov, Alina Sofronova, Oleg Stepanov, Nataliya Kudryashova, Gabriel Helmlinger, Kirill Peskov

    Diterbitkan 2022-04-01
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  7. 7
    Assessment of NSCLC disease burden: A survival model-based meta-analysis study

    Assessment of NSCLC disease burden: A survival model-based meta-analysis study oleh Nataliya Kudryashova, Boris Shulgin, Nikolai Katuninks, Victoria Kulesh, Gabriel Helmlinger, Kirill Zhudenkov, Kirill Peskov

    Diterbitkan 2024-12-01
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  8. 8
    Quantitative Mechanistic Modeling in Support of Pharmacological Therapeutics Development in Immuno-Oncology

    Quantitative Mechanistic Modeling in Support of Pharmacological Therapeutics Development in Immuno-Oncology oleh Kirill Peskov, Kirill Peskov, Ivan Azarov, Lulu Chu, Veronika Voronova, Yuri Kosinsky, Gabriel Helmlinger

    Diterbitkan 2019-04-01
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  9. 9
    Elaborating on anti CTLA-4 mechanisms of action using an agent-based modeling approach

    Elaborating on anti CTLA-4 mechanisms of action using an agent-based modeling approach oleh Ivan Azarov, Ivan Azarov, Gabriel Helmlinger, Yuri Kosinsky, Yuri Kosinsky, Kirill Peskov, Kirill Peskov, Kirill Peskov

    Diterbitkan 2022-10-01
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  10. 10
    Optimization of the MACE endpoint composition to increase power in studies of lipid-lowering therapies—a model-based meta-analysis

    Optimization of the MACE endpoint composition to increase power in studies of lipid-lowering therapies—a model-based meta-analysis oleh Alina Volkova, Alina Volkova, Boris Shulgin, Gabriel Helmlinger, Kirill Peskov, Kirill Peskov, Kirill Peskov, Victor Sokolov, Victor Sokolov

    Diterbitkan 2024-01-01
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  11. 11
    A Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human BeingsSummary

    A Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human BeingsSummary oleh Veronika Voronova, Victor Sokolov, Amani Al-Khaifi, Sara Straniero, Chanchal Kumar, Kirill Peskov, Gabriel Helmlinger, Mats Rudling, Bo Angelin

    Diterbitkan 2020-01-01
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  12. 12
    Mathematical modeling of endogenous and exogenously administered T cell recirculation in mouse and its application to pharmacokinetic studies of cell therapies

    Mathematical modeling of endogenous and exogenously administered T cell recirculation in mouse and its application to pharmacokinetic studies of cell therapies oleh Antonina Nikitich, Antonina Nikitich, Gabriel Helmlinger, Kirill Peskov, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov

    Diterbitkan 2024-04-01
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  13. 13
    An integrative mechanistic model of thymocyte dynamics

    An integrative mechanistic model of thymocyte dynamics oleh Victoria Kulesh, Victoria Kulesh, Kirill Peskov, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gabriel Helmlinger, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov

    Diterbitkan 2024-02-01
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  14. 14
    Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia[S]

    Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia[S] oleh Victor Sokolov, Gabriel Helmlinger, Catarina Nilsson, Kirill Zhudenkov, Stanko Skrtic, Bengt Hamrén, Kirill Peskov, Eva Hurt-Camejo, Rasmus Jansson-Löfmark

    Diterbitkan 2019-09-01
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  15. 15
    Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

    Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model oleh Yuri Kosinsky, Simon J. Dovedi, Kirill Peskov, Veronika Voronova, Lulu Chu, Helen Tomkinson, Nidal Al-Huniti, Donald R. Stanski, Gabriel Helmlinger

    Diterbitkan 2018-02-01
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  16. 16
    Differentiating the Sodium‐Glucose Cotransporter 1 Inhibition Capacity of Canagliflozin vs. Dapagliflozin and Empagliflozin Using Quantitative Systems Pharmacology Modeling

    Differentiating the Sodium‐Glucose Cotransporter 1 Inhibition Capacity of Canagliflozin vs. Dapagliflozin and Empagliflozin Using Quantitative Systems Pharmacology Modeling oleh Victor Sokolov, Tatiana Yakovleva, Lulu Chu, Weifeng Tang, Peter J. Greasley, Susanne Johansson, Kirill Peskov, Gabriel Helmlinger, David W. Boulton, Robert C. Penland

    Diterbitkan 2020-04-01
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  17. 17
    Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysis

    Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysis oleh Boris Shulgin, Yuri Kosinsky, Andrey Omelchenko, Lulu Chu, Ganesh Mugundu, Sergey Aksenov, Rodrigo Pimentel, Garrett DeYulia, Geoffrey Kim, Kirill Peskov, Gabriel Helmlinger

    Diterbitkan 2020-01-01
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  18. 18
    Mathematical modeling in autoimmune diseases: from theory to clinical application

    Mathematical modeling in autoimmune diseases: from theory to clinical application oleh Yaroslav Ugolkov, Yaroslav Ugolkov, Antonina Nikitich, Antonina Nikitich, Cristina Leon, Gabriel Helmlinger, Kirill Peskov, Kirill Peskov, Kirill Peskov, Kirill Peskov, Victor Sokolov, Victor Sokolov, Alina Volkova, Alina Volkova

    Diterbitkan 2024-03-01
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  19. 19
    Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model

    Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model oleh Veronika Voronova, Kirill Peskov, Kirill Peskov, Yuri Kosinsky, Gabriel Helmlinger, Lulu Chu, Alexandra Borodovsky, Richard Woessner, Kris Sachsenmeier, Wenlin Shao, Rakesh Kumar, Gayle Pouliot, Melinda Merchant, Holly Kimko, Ganesh Mugundu

    Diterbitkan 2021-03-01
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  20. 20
    Quantitative Systems Pharmacology: An Exemplar Model‐Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development

    Quantitative Systems Pharmacology: An Exemplar Model‐Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development oleh Gabriel Helmlinger, Victor Sokolov, Kirill Peskov, Karen M. Hallow, Yuri Kosinsky, Veronika Voronova, Lulu Chu, Tatiana Yakovleva, Ivan Azarov, Daniel Kaschek, Artem Dolgun, Henning Schmidt, David W. Boulton, Robert C. Penland

    Diterbitkan 2019-06-01
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