Single-Cell Mononucleotide Microsatellite Analysis Reveals Differential Insertion-Deletion Dynamics in Mouse T Cells by Elli-Mari Aska, Bulat Zagidullin, Bulat Zagidullin, Esa Pitkänen, Esa Pitkänen, Esa Pitkänen, Liisa Kauppi

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Spectral decoupling for training transferable neural networks in medical imaging by Joona Pohjonen, Carolin Stürenberg, Antti Rannikko, Tuomas Mirtti, Esa Pitkänen

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Towards pan-genome read alignment to improve variation calling by Daniel Valenzuela, Tuukka Norri, Niko Välimäki, Esa Pitkänen, Veli Mäkinen

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Whole-exome sequencing identifies novel candidate predisposition genes for familial polycythemia vera by Elina A. M. Hirvonen, Esa Pitkänen, Kari Hemminki, Lauri A. Aaltonen, Outi Kilpivaara

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Identification of multiplicatively acting modulatory mutational signatures in cancer by Dovydas Kičiatovas, Qingli Guo, Miika Kailas, Henri Pesonen, Jukka Corander, Samuel Kaski, Esa Pitkänen, Ville Mustonen

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Tackling the translational challenges of multi-omics research in the realm of European personalised medicine: A workshop report by Emanuela Oldoni, Gary Saunders, Florence Bietrix, Maria Laura Garcia Bermejo, Anna Niehues, Anna Niehues, Peter A. C. ’t Hoen, Jessica Nordlund, Marian Hajduch, Andreas Scherer, Katja Kivinen, Katja Kivinen, Katja Kivinen, Esa Pitkänen, Esa Pitkänen, Esa Pitkänen, Tomi Pekka Mäkela, Tomi Pekka Mäkela, Ivo Gut, Serena Scollen, Łukasz Kozera, Manel Esteller, Manel Esteller, Manel Esteller, Manel Esteller, Leming Shi, Anton Ussi, Antonio L. Andreu, Alain J. van Gool

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Detection of subclonal L1 transductions in colorectal cancer by long-distance inverse-PCR and Nanopore sequencing by Barun Pradhan, Tatiana Cajuso, Riku Katainen, Päivi Sulo, Tomas Tanskanen, Outi Kilpivaara, Esa Pitkänen, Lauri A. Aaltonen, Liisa Kauppi, Kimmo Palin

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Mutation-Attention (MuAt): deep representation learning of somatic mutations for tumour typing and subtyping by Prima Sanjaya, Katri Maljanen, Riku Katainen, Sebastian M. Waszak, Genomics England Research Consortium, Lauri A. Aaltonen, Oliver Stegle, Jan O. Korbel, Esa Pitkänen

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Comparative genome-scale reconstruction of gapless metabolic networks for present and ancestral species. by Esa Pitkänen, Paula Jouhten, Jian Hou, Muhammad Fahad Syed, Peter Blomberg, Jana Kludas, Merja Oja, Liisa Holm, Merja Penttilä, Juho Rousu, Mikko Arvas

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S175: SINGLE-CELL ANALYSIS REVEALS SOMATIC TP53 MUTATIONS EMERGE IN EARLY PROGENITOR CELLS BUT BECOME ENRICHED IN THE ERYTHROID LINEAGE IN ERCC6L2 DISEASE by Laura Langohr, Ilse Kaaja, Suvi Douglas, Tuulia Räisänen, Sadiksha Adhikari, Markus Vähä-Koskela, Caroline Heckman, Jenni Lahtela, Ulla Wartiovaara-Kautto, Esa Pitkänen, Outi Kilpivaara

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Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas by Hanna-Riikka Heinonen, Annukka Pasanen, Oskari Heikinheimo, Tomas Tanskanen, Kimmo Palin, Jaana Tolvanen, Pia Vahteristo, Jari Sjöberg, Esa Pitkänen, Ralf Bützow, Netta Mäkinen, Lauri A. Aaltonen

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Nationwide registry-based analysis of cancer clustering detects strong familial occurrence of Kaposi sarcoma. by Eevi Kaasinen, Mervi Aavikko, Pia Vahteristo, Toni Patama, Yilong Li, Silva Saarinen, Outi Kilpivaara, Esa Pitkänen, Paul Knekt, Maarit Laaksonen, Miia Artama, Rainer Lehtonen, Lauri A Aaltonen, Eero Pukkala

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Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia by Suvi P. M. Douglas, Atte K. Lahtinen, Jessica R. Koski, Lilli Leimi, Mikko A. I. Keränen, Minna Koskenvuo, Caroline A. Heckman, Kirsi Jahnukainen, Esa Pitkänen, Ulla Wartiovaara-Kautto, Outi Kilpivaara

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sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies by Reza Nasirigerdeh, Reihaneh Torkzadehmahani, Julian Matschinske, Tobias Frisch, Markus List, Julian Späth, Stefan Weiss, Uwe Völker, Esa Pitkänen, Dominik Heider, Nina Kerstin Wenke, Georgios Kaissis, Daniel Rueckert, Tim Kacprowski, Jan Baumbach

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Exome-wide somatic mutation characterization of small bowel adenocarcinoma. by Ulrika A Hänninen, Riku Katainen, Tomas Tanskanen, Roosa-Maria Plaketti, Riku Laine, Jiri Hamberg, Ari Ristimäki, Eero Pukkala, Minna Taipale, Jukka-Pekka Mecklin, Linda M Forsström, Esa Pitkänen, Kimmo Palin, Niko Välimäki, Netta Mäkinen, Lauri A Aaltonen

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Eleven candidate susceptibility genes for common familial colorectal cancer. by Alexandra E Gylfe, Riku Katainen, Johanna Kondelin, Tomas Tanskanen, Tatiana Cajuso, Ulrika Hänninen, Jussi Taipale, Minna Taipale, Laura Renkonen-Sinisalo, Heikki Järvinen, Jukka-Pekka Mecklin, Outi Kilpivaara, Esa Pitkänen, Pia Vahteristo, Sari Tuupanen, Auli Karhu, Lauri A Aaltonen

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Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones by Aleksandr Ianevski, Kristen Nader, Kyriaki Driva, Wojciech Senkowski, Daria Bulanova, Lidia Moyano-Galceran, Tanja Ruokoranta, Heikki Kuusanmäki, Nemo Ikonen, Philipp Sergeev, Markus Vähä-Koskela, Anil K. Giri, Anna Vähärautio, Mika Kontro, Kimmo Porkka, Esa Pitkänen, Caroline A. Heckman, Krister Wennerberg, Tero Aittokallio

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Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival by Tatiana Cajuso, Päivi Sulo, Tomas Tanskanen, Riku Katainen, Aurora Taira, Ulrika A. Hänninen, Johanna Kondelin, Linda Forsström, Niko Välimäki, Mervi Aavikko, Eevi Kaasinen, Ari Ristimäki, Selja Koskensalo, Anna Lepistö, Laura Renkonen-Sinisalo, Toni Seppälä, Teijo Kuopio, Jan Böhm, Jukka-Pekka Mecklin, Outi Kilpivaara, Esa Pitkänen, Kimmo Palin, Lauri A. Aaltonen

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Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancer by Johanna Kondelin, Kari Salokas, Lilli Saarinen, Kristian Ovaska, Heli Rauanheimo, Roosa‐Maria Plaketti, Jiri Hamberg, Xiaonan Liu, Leena Yadav, Alexandra E Gylfe, Tatiana Cajuso, Ulrika A Hänninen, Kimmo Palin, Heikki Ristolainen, Riku Katainen, Eevi Kaasinen, Tomas Tanskanen, Mervi Aavikko, Minna Taipale, Jussi Taipale, Laura Renkonen‐Sinisalo, Anna Lepistö, Selja Koskensalo, Jan Böhm, Jukka‐Pekka Mecklin, Halit Ongen, Emmanouil T Dermitzakis, Outi Kilpivaara, Pia Vahteristo, Mikko Turunen, Sampsa Hautaniemi, Sari Tuupanen, Auli Karhu, Niko Välimäki, Markku Varjosalo, Esa Pitkänen, Lauri A Aaltonen

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Contribution of allelic imbalance to colorectal cancer by Kimmo Palin, Esa Pitkänen, Mikko Turunen, Biswajyoti Sahu, Päivi Pihlajamaa, Teemu Kivioja, Eevi Kaasinen, Niko Välimäki, Ulrika A. Hänninen, Tatiana Cajuso, Mervi Aavikko, Sari Tuupanen, Outi Kilpivaara, Linda van den Berg, Johanna Kondelin, Tomas Tanskanen, Riku Katainen, Marta Grau, Heli Rauanheimo, Roosa-Maria Plaketti, Aurora Taira, Päivi Sulo, Tuomo Hartonen, Kashyap Dave, Bernhard Schmierer, Sandeep Botla, Maria Sokolova, Anna Vähärautio, Kornelia Gladysz, Halit Ongen, Emmanouil Dermitzakis, Jesper Bertram Bramsen, Torben Falck Ørntoft, Claus Lindbjerg Andersen, Ari Ristimäki, Anna Lepistö, Laura Renkonen-Sinisalo, Jukka-Pekka Mecklin, Jussi Taipale, Lauri A. Aaltonen

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