DRUGGABLE MM THERAPEUTICS: PATHOGENETIC PATHWAYS by Enrique M Ocio

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RELAPSED/REFRACTORY MULTIPLE MYELOMA: THE CURRENT STATE OF PLAY by María-Victoria Mateos, Enrique M. Ocio, Verónica González, Julio Dávila

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Drug-induced Thrombotic Microangiopathy During Maintenance Treatment in a Patient With Multiple Myeloma by Víctor Higuero Saavedra, Verónica González-Calle, Eduardo Sobejano, Josefa Sebastiá, Mónica Cabrero, Jose María Bastida, Noemi Puig, Enrique M. Ocio, María-Victoria Mateos

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CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype by Teresa Paíno, Enrique M. Ocio, Bruno Paiva, Laura San-Segundo, Mercedes Garayoa, Norma C. Gutiérrez, M. Eugenia Sarasquete, Atanasio Pandiella, Alberto Orfao, Jesús F. San Miguel

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The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype by Enrique Colado, Stela Álvarez-Fernández, Patricia Maiso, Jesús Martín-Sánchez, Maria Belén Vidriales, Mercedes Garayoa, Enrique M. Ocio, Juan Carlos Montero, Atanasio Pandiella, Jesús F. San Miguel

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Phase 1b Study of Isatuximab in Combination With Bortezomib, Cyclophosphamide, and Dexamethasone in Newly Diagnosed, Transplant-ineligible Multiple Myeloma Patients by Enrique M. Ocio, Sara Bringhen, Joaquin Martinez-Lopez, Jesus San-Miguel, Stefania Oliva, Paula Rodriguez-Otero, Nadia Le Roux, Yvonne Dong, Severine Doroumian, Sandrine Macé, Maria-Victoria Mateos

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Evidence of long-term disease control with panobinostat maintenance in patients with relapsed multiple myeloma by Enrique M. Ocio, Julio Dávila, Juan-Carlos Caballero, Sara Alonso, Verónica González de la Calle, Ramón García-Sanz, Lucien Gazi, Socrates Opio, Mónica Jiménez, Jesús F. San-Miguel, María-Victoria Mateos

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Phenotypic, genomic and functional characterization reveals no differences between CD138++ and CD138low subpopulations in multiple myeloma cell lines. by Teresa Paíno, María E Sarasquete, Bruno Paiva, Patryk Krzeminski, Laura San-Segundo, Luis A Corchete, Alba Redondo, Mercedes Garayoa, Ramón García-Sanz, Norma C Gutiérrez, Enrique M Ocio, Jesús F San-Miguel

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Restoration of microRNA-214 expression reduces growth of myeloma cells through positive regulation of P53 and inhibition of DNA replication by Irena Misiewicz-Krzeminska, María E. Sarasquete, Dalia Quwaider, Patryk Krzeminski, Fany V. Ticona, Teresa Paíno, Manuel Delgado, Andreia Aires, Enrique M. Ocio, Ramón García-Sanz, Jesús F. San Miguel, Norma C. Gutiérrez

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ANCHOR: melflufen plus dexamethasone and daratumumab or bortezomib in relapsed/refractory multiple myeloma: final results of a phase I/IIa study by Enrique M. Ocio, Yvonne A. Efebera, Roman Hájek, Jan Straub, Vladimir Maisnar, Jean-Richard Eveillard, Lionel Karlin, María-Victoria Mateos, Albert Oriol, Vincent Ribrag, Paul G. Richardson, Stefan Norin, Jakob Obermüller, Nicolaas A. Bakker, Luděk Pour

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A multi-center, phase Ib study of subcutaneous administration of isatuximab in combination with pomalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma by Hang Quach, Gurdeep Parmar, Enrique M. Ocio, H. Miles Prince, Albert Oriol, Helen Crowther, Nobuhiro Tsukada, Pierre Bories, Sumit Madan, Nitya Nathwani, Kazutaka Sunami, Dorothee Semiond, Disa Yu, Paul Cordero, Sandrine Macé, Florence Suzan, Philippe Moreau

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In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma by Enrique M. Ocio, David Vilanova, Peter Atadja, Patricia Maiso, Edvan Crusoe, Diego Fernández-Lázaro, Mercedes Garayoa, Laura San-Segundo, Teresa Hernández-Iglesias, Enrique de Álava, Wenlin Shao, Yung-Mae Yao, Atanasio Pandiella, Jesús F. San-Miguel

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The prognostic value of multiparameter flow cytometry minimal residual disease assessment in relapsed multiple myeloma by Bruno Paiva, Mauricio Chandia, Noemi Puig, Maria-Belen Vidriales, Jose J. Perez, Lucia Lopez-Corral, Enrique M. Ocio, Ramon Garcia-Sanz, Norma C. Gutierrez, Ana Jimenez-Ubieto, Juan-José Lahuerta, Maria-Victoria Mateos, Jesús F. San Miguel

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Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone by Ana-Alicia López-Iglesias, Lorena González-Méndez, Laura San-Segundo, Ana B. Herrero, Susana Hernández-García, Montserrat Martín-Sánchez, Norma C. Gutiérrez, Teresa Paíno, Pablo Avilés, María-Victoria Mateos, Jesús F. San-Miguel, Mercedes Garayoa, Enrique M. Ocio

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Phase I study of plitidepsin in combination with bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma by María Victoria Mateos, Felipe Prosper, Jesús Martin Sánchez, Enrique M. Ocio, Albert Oriol, Cristina Motlló, Jean‐Marie Michot, Isidro Jarque, Rebeca Iglesias, María Solé, Sara Martínez, Carmen Kahatt, Salvador Fudio, Gema Corral, Ali Zeaiter, Lola Montilla, Vincent Ribrag

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Tinostamustine (EDO-S101), an Alkylating Deacetylase Inhibitor, Enhances the Efficacy of Daratumumab in Multiple Myeloma by Upregulation of CD38 and NKG2D Ligands by Andrea Díaz-Tejedor, Javier Rodríguez-Ubreva, Laura Ciudad, Mauro Lorenzo-Mohamed, Marta González-Rodríguez, Bárbara Castellanos, Janet Sotolongo-Ravelo, Laura San-Segundo, Luis A. Corchete, Lorena González-Méndez, Montserrat Martín-Sánchez, María-Victoria Mateos, Enrique M. Ocio, Mercedes Garayoa, Teresa Paíno

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Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects. by Antonio Garcia-Gomez, Enrique M Ocio, Edvan Crusoe, Carlos Santamaria, Pilar Hernández-Campo, Juan F Blanco, Fermin M Sanchez-Guijo, Teresa Hernández-Iglesias, Jesús G Briñón, Rosa M Fisac-Herrero, Francis Y Lee, Atanasio Pandiella, Jesús F San Miguel, Mercedes Garayoa

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Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma by Esperanza M. Algarín, Dalia Quwaider, Francisco J. Campos-Laborie, Andrea Díaz-Tejedor, Pedro Mogollón, Elena Vuelta, Montserrat Martín-Sánchez, Laura San-Segundo, Lorena González-Méndez, Norma C. Gutiérrez, Ramón García-Sanz, Teresa Paíno, Javier De Las Rivas, Enrique M. Ocio, Mercedes Garayoa

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Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response by Enrique Colado, Teresa Paíno, Patricia Maiso, Enrique M. Ocio, Xi Chen, Stela Álvarez-Fernández, Norma C. Gutiérrez, Jesús Martín-Sánchez, Juan Flores-Montero, Laura San Segundo, Mercedes Garayoa, Diego Fernández-Lázaro, Maria-Belen Vidriales, Carlos M. Galmarini, Pablo Avilés, Carmen Cuevas, Atanasio Pandiella, Jesús F. San-Miguel

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Panobinostat as part of induction and maintenance for elderly patients with newly diagnosed acute myeloid leukemia: phase Ib/II panobidara study by Enrique M. Ocio, Pilar Herrera, María-Teresa Olave, Nerea Castro, José A. Pérez-Simón, Salut Brunet, Albert Oriol, Marta Mateo, Miguel-Ángel Sanz, Javier López, Pau Montesinos, María-Carmen Chillón, María-Isabel Prieto-Conde, María Díez-Campelo, Marcos González, María-Belén Vidriales, María-Victoria Mateos, Jesús F. San Miguel

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