Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands by Johannes M Freudenberg, Ian Dunham, Philippe Sanseau, Deepak K Rajpal

Get full text

Empowering the discovery of novel target-disease associations via machine learning approaches in the open targets platform by Yingnan Han, Katherine Klinger, Deepak K. Rajpal, Cheng Zhu, Erin Teeple

Get full text

An integrative network-based approach for drug target indication expansion. by Yingnan Han, Clarence Wang, Katherine Klinger, Deepak K Rajpal, Cheng Zhu

Get full text

Genome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research Repository by Samuel Lessard, Chunla He, Deepak K. Rajpal, Katherine Klinger, Christine Loh, Tim Harris, Jennifer Dumont

Get full text

A Hidradenitis Suppurativa molecular disease signature derived from patient samples by high-throughput RNA sequencing and re-analysis of previously reported transcriptomic data set... by Johannes M Freudenberg, Zhi Liu, Jennifer Singh, Elizabeth Thomas, Christopher Traini, Deepak K Rajpal, Christopher J Sayed

Get full text

A Hidradenitis Suppurativa molecular disease signature derived from patient samples by high-throughput RNA sequencing and re-analysis of previously reported transcriptomic data set... by Johannes M. Freudenberg, Zhi Liu, Jennifer Singh, Elizabeth Thomas, Christopher Traini, Deepak K. Rajpal, Christopher J. Sayed

Get full text

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models. by Deepak K Rajpal, Jean-Louis Klein, David Mayhew, Joyce Boucheron, Aaron T Spivak, Vinod Kumar, Karen Ingraham, Mark Paulik, Lihong Chen, Stephanie Van Horn, Elizabeth Thomas, Ganesh Sathe, George P Livi, David J Holmes, James R Brown

Get full text

Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease. by William C Reisdorf, Qing Xie, Xin Zeng, Wensheng Xie, Neetu Rajpal, Bao Hoang, Mark E Burgert, Vinod Kumar, Mark R Hurle, Deepak K Rajpal, Sarah O'Donnell, Thomas T MacDonald, Anna Vossenkämper, Lin Wang, Mike Reilly, Bart J Votta, Yolanda Sanchez, Pankaj Agarwal

Get full text

Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility. by Shian-Huey Chiang, W Wallace Harrington, Guizhen Luo, Naphtali O Milliken, John C Ulrich, Jing Chen, Deepak K Rajpal, Ying Qian, Tiffany Carpenter, Rusty Murray, Robert S Geske, Stephen A Stimpson, Henning F Kramer, Curt D Haffner, J David Becherer, Frank Preugschat, Andrew N Billin

Get full text

Phenome-wide association study using research participants' self-reported data provides insight into the Th17 and IL-17 pathway. by Margaret G Ehm, Jennifer L Aponte, Mathias N Chiano, Laura M Yerges-Armstrong, Toby Johnson, Jonathan N Barker, Suzanne F Cook, Akanksha Gupta, David A Hinds, Li Li, Matthew R Nelson, Michael A Simpson, Chao Tian, Linda C McCarthy, Deepak K Rajpal, Dawn M Waterworth

Get full text

Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury by Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell

Get full text

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury by Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell

Get full text

Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress by Pu Qin, Pelin Arabacilar, Roberta E. Bernard, Weike Bao, Alan R. Olzinski, Yuanjun Guo, Hind Lal, Stephen H. Eisennagel, Michael C. Platchek, Wensheng Xie, Julius del Rosario, Mohamad Nayal, Quinn Lu, Theresa Roethke, Christine G. Schnackenberg, Fe Wright, Michael P. Quaile, Wendy S. Halsey, Ashley M. Hughes, Ganesh M. Sathe, George P. Livi, Robert B. Kirkpatrick, Xiaoyan A. Qu, Deepak K. Rajpal, Maria Faelth Savitski, Marcus Bantscheff, Gerard Joberty, Giovanna Bergamini, Thomas L. Force, Gregory J. Gatto, Erding Hu, Robert N. Willette

Get full text

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness by Sara M. Willems, Daniel J. Wright, Felix R. Day, Katerina Trajanoska, Peter K. Joshi, John A. Morris, Amy M. Matteini, Fleur C. Garton, Niels Grarup, Nikolay Oskolkov, Anbupalam Thalamuthu, Massimo Mangino, Jun Liu, Ayse Demirkan, Monkol Lek, Liwen Xu, Guan Wang, Christopher Oldmeadow, Kyle J. Gaulton, Luca A. Lotta, Eri Miyamoto-Mikami, Manuel A. Rivas, Tom White, Po-Ru Loh, Mette Aadahl, Najaf Amin, John R. Attia, Krista Austin, Beben Benyamin, Søren Brage, Yu-Ching Cheng, Paweł Cięszczyk, Wim Derave, Karl-Fredrik Eriksson, Nir Eynon, Allan Linneberg, Alejandro Lucia, Myosotis Massidda, Braxton D. Mitchell, Motohiko Miyachi, Haruka Murakami, Sandosh Padmanabhan, Ashutosh Pandey, Ioannis Papadimitriou, Deepak K. Rajpal, Craig Sale, Theresia M. Schnurr, Francesco Sessa, Nick Shrine, Martin D. Tobin, Ian Varley, Louise V. Wain, Naomi R. Wray, Cecilia M. Lindgren, Daniel G. MacArthur, Dawn M. Waterworth, Mark I. McCarthy, Oluf Pedersen, Kay-Tee Khaw, Douglas P. Kiel, GEFOS Any-Type of Fracture Consortium, Yannis Pitsiladis, Noriyuki Fuku, Paul W. Franks, Kathryn N. North, Cornelia M. van Duijn, Karen A. Mather, Torben Hansen, Ola Hansson, Tim Spector, Joanne M. Murabito, J. Brent Richards, Fernando Rivadeneira, Claudia Langenberg, John R. B. Perry, Nick J. Wareham, Robert A. Scott

Get full text