Hasil Pencarian - David E. Root

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  1. 1
    Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool.

    Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool. oleh Katherine F Donovan, Mudra Hegde, Meagan Sullender, Emma W Vaimberg, Cory M Johannessen, David E Root, John G Doench

    Diterbitkan 2017-01-01
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  2. 2
    Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

    Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression oleh Joseph Rosenbluh, Han Xu, William Harrington, Stanley Gill, Xiaoxing Wang, Francisca Vazquez, David E. Root, Aviad Tsherniak, William C. Hahn

    Diterbitkan 2017-05-01
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  3. 3
    Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects

    Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects oleh Joshua M. Dempster, Isabella Boyle, Francisca Vazquez, David E. Root, Jesse S. Boehm, William C. Hahn, Aviad Tsherniak, James M. McFarland

    Diterbitkan 2021-12-01
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  4. 4
    Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

    Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus oleh Clotilde Guyon, Nada Jmari, Francine Padonou, Yen-Chin Li, Olga Ucar, Noriyuki Fujikado, Fanny Coulpier, Christophe Blanchet, David E Root, Matthieu Giraud

    Diterbitkan 2020-04-01
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  5. 5
    Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects.

    Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects. oleh Shantanu Singh, Xiaoyun Wu, Vebjorn Ljosa, Mark-Anthony Bray, Federica Piccioni, David E Root, John G Doench, Jesse S Boehm, Anne E Carpenter

    Diterbitkan 2015-01-01
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  6. 6
    High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons.

    High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons. oleh Thomas J F Nieland, David J Logan, Jessica Saulnier, Daniel Lam, Caroline Johnson, David E Root, Anne E Carpenter, Bernardo L Sabatini

    Diterbitkan 2014-01-01
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  7. 7
    A Targeted RNA Interference Screen Reveals Novel Epigenetic Factors That Regulate Herpesviral Gene Expression

    A Targeted RNA Interference Screen Reveals Novel Epigenetic Factors That Regulate Herpesviral Gene Expression oleh Hyung Suk Oh, Kevin F. Bryant, Thomas J. F. Nieland, Aprotim Mazumder, Mukta Bagul, Mark Bathe, David E. Root, David M. Knipe

    Diterbitkan 2014-02-01
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  8. 8
    Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis

    Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis oleh Baobing Zhao, Ganesan Keerthivasan, Yang Mei, Jing Yang, James McElherne, Piu Wong, John G. Doench, Gang Feng, David E. Root, Peng Ji

    Diterbitkan 2014-07-01
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  9. 9
    CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines

    CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines oleh Daniel J. Merk, Linda Paul, Foteini Tsiami, Helen Hohenthanner, Ghazal Mohseni Kouchesfahani, Lara A. Haeusser, Bianca Walter, Adam Brown, Nicole S. Persky, David E. Root, Ghazaleh Tabatabai

    Diterbitkan 2024-06-01
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  10. 10
    Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map.

    Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map. oleh Ian Smith, Peyton G Greenside, Ted Natoli, David L Lahr, David Wadden, Itay Tirosh, Rajiv Narayan, David E Root, Todd R Golub, Aravind Subramanian, John G Doench

    Diterbitkan 2017-11-01
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  11. 11
    Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

    Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities oleh Kendall R. Sanson, Ruth E. Hanna, Mudra Hegde, Katherine F. Donovan, Christine Strand, Meagan E. Sullender, Emma W. Vaimberg, Amy Goodale, David E. Root, Federica Piccioni, John G. Doench

    Diterbitkan 2018-12-01
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  12. 12
    Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma

    Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma oleh Foteini Tsiami, Chiara Lago, Noemi Pozza, Federica Piccioni, Xuesong Zhao, Fabienne Lülsberg, David E. Root, Luca Tiberi, Marcel Kool, Jens Schittenhelm, Pratiti Bandopadhayay, Rosalind A. Segal, Ghazaleh Tabatabai, Daniel J. Merk

    Diterbitkan 2024-08-01
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  13. 13
    Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal

    Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal oleh J. Michael Krill-Burger, Joshua M. Dempster, Ashir A. Borah, Brenton R. Paolella, David E. Root, Todd R. Golub, Jesse S. Boehm, William C. Hahn, James M. McFarland, Francisca Vazquez, Aviad Tsherniak

    Diterbitkan 2023-08-01
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  14. 14
    The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.

    The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. oleh Claire Marie Filone, Ignacio S Caballero, Ken Dower, Marc L Mendillo, Glenn S Cowley, Sandro Santagata, Daniel K Rozelle, Judy Yen, Kathleen H Rubins, Nir Hacohen, David E Root, Lisa E Hensley, John Connor

    Diterbitkan 2014-02-01
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  15. 15
    CK1epsilon is required for breast cancers dependent on beta-catenin activity.

    CK1epsilon is required for breast cancers dependent on beta-catenin activity. oleh So Young Kim, Ian F Dunn, Ron Firestein, Piyush Gupta, Leslie Wardwell, Kara Repich, Anna C Schinzel, Ben Wittner, Serena J Silver, David E Root, Jesse S Boehm, Sridhar Ramaswamy, Eric S Lander, William C Hahn

    Diterbitkan 2010-02-01
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  16. 16
    Correction: Corrigendum: PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA

    Correction: Corrigendum: PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA oleh Tovah A. Day, Jacob V. Layer, J. Patrick Cleary, Srijoy Guha, Kristen E. Stevenson, Trevor Tivey, Sunhee Kim, Anna C Schinzel, Francesca Izzo, John Doench, David E. Root, William C. Hahn, Brendan D. Price, David M. Weinstock

    Diterbitkan 2017-06-01
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  17. 17
    PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA

    PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA oleh Tovah A. Day, Jacob V. Layer, J. Patrick Cleary, Srijoy Guha, Kristen E. Stevenson, Trevor Tivey, Sunhee Kim, Anna C. Schinzel, Francesca Izzo, John Doench, David E. Root, William C. Hahn, Brendan D. Price, David M. Weinstock

    Diterbitkan 2017-04-01
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  18. 18
    Mapping the landscape of genetic dependencies in chordoma

    Mapping the landscape of genetic dependencies in chordoma oleh Tanaz Sharifnia, Mathias J. Wawer, Amy Goodale, Yenarae Lee, Mariya Kazachkova, Joshua M. Dempster, Sandrine Muller, Joan Levy, Daniel M. Freed, Josh Sommer, Jérémie Kalfon, Francisca Vazquez, William C. Hahn, David E. Root, Paul A. Clemons, Stuart L. Schreiber

    Diterbitkan 2023-04-01
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  19. 19
    Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants

    Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants oleh Lisa Brenan, Aleksandr Andreev, Ofir Cohen, Sasha Pantel, Atanas Kamburov, Davide Cacchiarelli, Nicole S. Persky, Cong Zhu, Mukta Bagul, Eva M. Goetz, Alex B. Burgin, Levi A. Garraway, Gad Getz, Tarjei S. Mikkelsen, Federica Piccioni, David E. Root, Cory M. Johannessen

    Diterbitkan 2016-10-01
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  20. 20
    Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries

    Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries oleh Sean A. Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G. Doench, David E. Root, James M. McFarland, Rameen Beroukhim, Jesse S. Boehm

    Diterbitkan 2024-06-01
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