Hasil Pencarian - Armin Giese

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  1. 1
    Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes.

    Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes. oleh Felix Schmidt, Johannes Levin, Frits Kamp, Hans Kretzschmar, Armin Giese, Kai Bötzel

    Diterbitkan 2012-01-01
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  2. 2
    The number of methylated CpG sites within the MGMT promoter region linearly correlates with outcome in glioblastoma receiving alkylating agents

    The number of methylated CpG sites within the MGMT promoter region linearly correlates with outcome in glioblastoma receiving alkylating agents oleh Sebastian Siller, Michael Lauseker, Philipp Karschnia, Maximilian Niyazi, Sabina Eigenbrod, Armin Giese, Joerg-Christian Tonn

    Diterbitkan 2021-03-01
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  3. 3
    Seeding and transgenic overexpression of alpha‐synuclein triggers dendritic spine pathology in the neocortex

    Seeding and transgenic overexpression of alpha‐synuclein triggers dendritic spine pathology in the neocortex oleh Sonja Blumenstock, Eva F Rodrigues, Finn Peters, Lidia Blazquez‐Llorca, Felix Schmidt, Armin Giese, Jochen Herms

    Diterbitkan 2017-03-01
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  4. 4
    Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease.

    Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease. oleh Kamran Honarnejad, Alexander Daschner, Armin Giese, Andrea Zall, Boris Schmidt, Aleksandra Szybinska, Jacek Kuznicki, Jochen Herms

    Diterbitkan 2013-01-01
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  5. 5
    Potential sources of interference with the highly sensitive detection and quantification of alpha‐synuclein seeds by qRT‐QuIC

    Potential sources of interference with the highly sensitive detection and quantification of alpha‐synuclein seeds by qRT‐QuIC oleh Viktoria C. Ruf, Song Shi, Felix Schmidt, Daniel Weckbecker, Georg S. Nübling, Uwe Ködel, Brit Mollenhauer, Armin Giese

    Diterbitkan 2020-05-01
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  6. 6
    Modelling Ser129 phosphorylation inhibits membrane binding of pore-forming alpha-synuclein oligomers.

    Modelling Ser129 phosphorylation inhibits membrane binding of pore-forming alpha-synuclein oligomers. oleh Georg Sebastian Nübling, Johannes Levin, Benedikt Bader, Stefan Lorenzl, Andreas Hillmer, Tobias Högen, Frits Kamp, Armin Giese

    Diterbitkan 2014-01-01
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  7. 7
    Investigation of potential adverse central nervous system effects after long term oral administration of gadolinium in mice.

    Investigation of potential adverse central nervous system effects after long term oral administration of gadolinium in mice. oleh Dominik Nörenberg, Felix Schmidt, Karin Schinke, Thomas Frenzel, Hubertus Pietsch, Armin Giese, Birgit Ertl-Wagner, Johannes Levin

    Diterbitkan 2020-01-01
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  8. 8
    Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease

    Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease oleh Benedikt Kretner, Johannes Trambauer, Akio Fukumori, Janina Mielke, Peer‐Hendrik Kuhn, Elisabeth Kremmer, Armin Giese, Stefan F Lichtenthaler, Christian Haass, Thomas Arzberger, Harald Steiner

    Diterbitkan 2016-03-01
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  9. 9
    Visinin-like protein 1 levels in blood and CSF as emerging markers for Alzheimer’s and other neurodegenerative diseases

    Visinin-like protein 1 levels in blood and CSF as emerging markers for Alzheimer’s and other neurodegenerative diseases oleh Steffen Halbgebauer, Petra Steinacker, Daniel Riedel, Patrick Oeckl, Sarah Anderl-Straub, Jolina Lombardi, Christine A. F. von Arnim, Magdalena Nagl, Armin Giese, Albert C. Ludolph, Markus Otto

    Diterbitkan 2022-11-01
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  10. 10
    Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance

    Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance oleh Miguel Lemos, Serena Venezia, Violetta Refolo, Antonio Heras-Garvin, Sabine Schmidhuber, Armin Giese, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Gergana Galabova, Guenther Staffler, Gregor Karl Wenning, Nadia Stefanova

    Diterbitkan 2020-09-01
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  11. 11
    Travel-associated neurological disease terminated in a postmortem diagnosed atypical HSV-1 encephalitis after high-dose steroid therapy – a case report

    Travel-associated neurological disease terminated in a postmortem diagnosed atypical HSV-1 encephalitis after high-dose steroid therapy – a case report oleh Andreas Osterman, Viktoria C. Ruf, Cristina Domingo, Andreas Nitsche, Peter Eichhorn, Hanna Zimmermann, Klaus Seelos, Sabine Zange, Konstantinos Dimitriadis, Hans-Walter Pfister, Thorsten Thye, Armin Giese, Dennis Tappe, Stephan Böhm

    Diterbitkan 2020-02-01
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  12. 12
    Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice.

    Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice. oleh Sabina Eigenbrod, Petra Frick, Uwe Bertsch, Gerda Mitteregger-Kretzschmar, Janina Mielke, Marko Maringer, Niklas Piening, Alexander Hepp, Nathalie Daude, Otto Windl, Johannes Levin, Armin Giese, Vignesh Sakthivelu, Jörg Tatzelt, Hans Kretzschmar, David Westaway

    Diterbitkan 2017-01-01
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  13. 13
    The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils

    The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils oleh Leif Antonschmidt, Dirk Matthes, Rıza Dervişoğlu, Benedikt Frieg, Christian Dienemann, Andrei Leonov, Evgeny Nimerovsky, Vrinda Sant, Sergey Ryazanov, Armin Giese, Gunnar F. Schröder, Stefan Becker, Bert L. de Groot, Christian Griesinger, Loren B. Andreas

    Diterbitkan 2022-09-01
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  14. 14
    Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial

    Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, dou... oleh Johannes Levin, Nand Sing, Sue Melbourne, Amber Morgan, Carla Mariner, Maria Grazia Spillantini, Michal Wegrzynowicz, Jeffrey W. Dalley, Simon Langer, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Felix Schmidt, Daniel Weckbecker, Kai Prager, Torsten Matthias, Armin Giese

    Diterbitkan 2022-06-01
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  15. 15
    Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein

    Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein oleh Yanina Dening, Theresa Straßl, Viktoria Ruf, Petra Dirscherl, Alexandra Chovsepian, Alicia Stievenard, Amit Khairnar, Felix Schmidt, Florian Giesert, Jochen Herms, Johannes Levin, Marianne Dieterich, Peter Falkai, Daniela Vogt Weisenhorn, Wolfgang Wurst, Armin Giese, Francisco Pan-Montojo

    Diterbitkan 2022-12-01
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  16. 16
    DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex

    DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex oleh Gilles Gasparoni, Sebastian Bultmann, Pavlo Lutsik, Theo F. J. Kraus, Sabrina Sordon, Julia Vlcek, Vanessa Dietinger, Martina Steinmaurer, Melanie Haider, Christopher B. Mulholland, Thomas Arzberger, Sigrun Roeber, Matthias Riemenschneider, Hans A. Kretzschmar, Armin Giese, Heinrich Leonhardt, Jörn Walter

    Diterbitkan 2018-07-01
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  17. 17
    Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau

    Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau oleh Matthias Brendel, Maximilian Deussing, Tanja Blume, Lena Kaiser, Federico Probst, Felix Overhoff, Finn Peters, Barbara von Ungern-Sternberg, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Andreas Zwergal, Johannes Levin, Peter Bartenstein, Igor Yakushev, Paul Cumming, Guido Boening, Sibylle Ziegler, Jochen Herms, Armin Giese, Axel Rominger

    Diterbitkan 2019-08-01
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  18. 18
    The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology

    The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology oleh Ana Martinez Hernandez, Hendrik Urbanke, Alan L Gillman, Joon Lee, Sergey Ryazanov, Hope Y Agbemenyah, Eva Benito, Gaurav Jain, Lalit Kaurani, Gayane Grigorian, Andrei Leonov, Nasrollah Rezaei‐Ghaleh, Petra Wilken, Fernando Teran Arce, Jens Wagner, Martin Fuhrmann, Mario Caruana, Angelique Camilleri, Neville Vassallo, Markus Zweckstetter, Roland Benz, Armin Giese, Anja Schneider, Martin Korte, Ratnesh Lal, Christian Griesinger, Gregor Eichele, Andre Fischer

    Diterbitkan 2017-12-01
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  19. 19
    Risk willingness in multiple system atrophy and Parkinson’s disease understanding patient preferences

    Risk willingness in multiple system atrophy and Parkinson’s disease understanding patient preferences oleh Alexander Maximilian Bernhardt, Marc Oeller, Isabel Friedrich, Emre Kocakavuk, Eliana Nachman, Kevin Peikert, Malte Roderigo, Andreas Rossmann, Tabea Schröter, Lea Olivia Wilhelm, Tino Prell, Christoph van Riesen, Johanna Nieweler, Sabrina Katzdobler, Markus Weiler, Heike Jacobi, Tobias Warnecke, Inga Claus, Carla Palleis, Stephan Breimann, Björn Falkenburger, Moritz Brandt, Andreas Hermann, Jost-Julian Rumpf, Joseph Claßen, Günter Höglinger, Florin Gandor, Johannes Levin, Armin Giese, Annette Janzen, Wolfgang Hermann Oertel

    Diterbitkan 2024-08-01
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  20. 20
    A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex

    A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex oleh Rebecca G. Smith, Ehsan Pishva, Gemma Shireby, Adam R. Smith, Janou A. Y. Roubroeks, Eilis Hannon, Gregory Wheildon, Diego Mastroeni, Gilles Gasparoni, Matthias Riemenschneider, Armin Giese, Andrew J. Sharp, Leonard Schalkwyk, Vahram Haroutunian, Wolfgang Viechtbauer, Daniel L. A. van den Hove, Michael Weedon, Danielle Brokaw, Paul T. Francis, Alan J. Thomas, Seth Love, Kevin Morgan, Jörn Walter, Paul D. Coleman, David A. Bennett, Philip L. De Jager, Jonathan Mill, Katie Lunnon

    Diterbitkan 2021-06-01
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