Hasil Pencarian - Alexander J Whitworth

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  1. 1
    FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo.

    FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo. oleh Alvaro Sanchez-Martinez, Aitor Martinez, Alexander J Whitworth

    Diterbitkan 2023-08-01
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  2. 2
    Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.

    Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes. oleh Ana Terriente-Felix, Emma L Wilson, Alexander J Whitworth

    Diterbitkan 2020-10-01
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  3. 3
    Antioxidant Therapy in Parkinson’s Disease: Insights from <i>Drosophila melanogaster</i>

    Antioxidant Therapy in Parkinson’s Disease: Insights from <i>Drosophila melanogaster</i> oleh Federica De Lazzari, Federica Sandrelli, Alexander J. Whitworth, Marco Bisaglia

    Diterbitkan 2020-01-01
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  4. 4
    DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury

    DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury oleh Federica De Lazzari, Hiran A. Prag, Anja V. Gruszczyk, Alexander J. Whitworth, Marco Bisaglia

    Diterbitkan 2021-05-01
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  5. 5
    Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster

    Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster oleh Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst

    Diterbitkan 2023-01-01
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  6. 6
    The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy.

    The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy. oleh Joe H Pogson, Rachael M Ivatt, Alvaro Sanchez-Martinez, Roberta Tufi, Emma Wilson, Heather Mortiboys, Alexander J Whitworth

    Diterbitkan 2014-11-01
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  7. 7
    Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects.

    Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects. oleh Alvaro Sanchez-Martinez, Manuel Calleja, Susana Peralta, Yuichi Matsushima, Rosana Hernandez-Sierra, Alexander J Whitworth, Laurie S Kaguni, Rafael Garesse

    Diterbitkan 2012-01-01
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  8. 8
    USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the <i>Drosophila</i> Brain and in Human Neurons

    USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the <i>Drosophila</i> Brain and in Human Neurons oleh Sofia Mauri, Greta Bernardo, Aitor Martinez, Mariavittoria Favaro, Marta Trevisan, Gael Cobraiville, Marianne Fillet, Federico Caicci, Alexander J. Whitworth, Elena Ziviani

    Diterbitkan 2023-04-01
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  9. 9
    Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models

    Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models oleh Aitor Martinez, Alvaro Sanchez-Martinez, Jake T. Pickering, Madeleine J. Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J. Whitworth

    Diterbitkan 2024-01-01
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  10. 10
    DJ-1 promotes energy balance by regulating both mitochondrial and autophagic homeostasis

    DJ-1 promotes energy balance by regulating both mitochondrial and autophagic homeostasis oleh Federica De Lazzari, Francesco Agostini, Nicoletta Plotegher, Michele Sandre, Elisa Greggio, Aram Megighian, Luigi Bubacco, Federica Sandrelli, Alexander J. Whitworth, Marco Bisaglia

    Diterbitkan 2023-01-01
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  11. 11
    An assessment of the rescue action of resveratrol in parkin loss of function-induced oxidative stress in Drosophila melanogaster

    An assessment of the rescue action of resveratrol in parkin loss of function-induced oxidative stress in Drosophila melanogaster oleh Adeola O. Adedara, Ayoade D. Babalola, Flora Stephano, Ifeoluwa O. Awogbindin, James O. Olopade, João B. T. Rocha, Alexander J. Whitworth, Amos O. Abolaji

    Diterbitkan 2022-03-01
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  12. 12
    Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disorders.

    Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disorders. oleh Domenica Lovero, Luca Giordano, René Massimiliano Marsano, Alvaro Sanchez-Martinez, Hadi Boukhatmi, Maik Drechsler, Marta Oliva, Alexander J Whitworth, Damiano Porcelli, Corrado Caggese

    Diterbitkan 2018-01-01
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  13. 13
    Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo

    Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo oleh Roberta Tufi, Thomas P. Gleeson, Sophia von Stockum, Victoria L. Hewitt, Juliette J. Lee, Ana Terriente-Felix, Alvaro Sanchez-Martinez, Elena Ziviani, Alexander J. Whitworth

    Diterbitkan 2019-04-01
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  14. 14
    Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease models

    Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease models oleh Madeleine J. Twyning, Roberta Tufi, Thomas P. Gleeson, Kinga M. Kolodziej, Susanna Campesan, Ana Terriente-Felix, Lewis Collins, Federica De Lazzari, Flaviano Giorgini, Alexander J. Whitworth

    Diterbitkan 2024-02-01
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  15. 15
    Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

    Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration oleh Andrea Loreto, Ciaran S. Hill, Victoria L. Hewitt, Giuseppe Orsomando, Carlo Angeletti, Jonathan Gilley, Cristiano Lucci, Alvaro Sanchez-Martinez, Alexander J. Whitworth, Laura Conforti, Federico Dajas-Bailador, Michael P. Coleman

    Diterbitkan 2020-02-01
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  16. 16
    Protective capacity of carotenoid trans-astaxanthin in rotenone-induced toxicity in Drosophila melanogaster

    Protective capacity of carotenoid trans-astaxanthin in rotenone-induced toxicity in Drosophila melanogaster oleh Temitope C. Akinade, Oreoluwa O. Babatunde, Adeola O. Adedara, Olugbenga E. Adeyemi, Titilayomi A. Otenaike, Onaara P. Ashaolu, Titilayo O. Johnson, Ana Terriente-Felix, Alexander J. Whitworth, Amos O. Abolaji

    Diterbitkan 2022-03-01
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  17. 17
    Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations

    Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations oleh Helen I. Woodroof, Joe H. Pogson, Mike Begley, Lewis C. Cantley, Maria Deak, David G. Campbell, Daan M. F. van Aalten, Alexander J. Whitworth, Dario R. Alessi, Miratul M. K. Muqit

    Diterbitkan 2011-01-01
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  18. 18
    A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit

    A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit oleh Pedro Rebelo-Guiomar, Simone Pellegrino, Kyle C. Dent, Aldema Sas-Chen, Leonor Miller-Fleming, Caterina Garone, Lindsey Van Haute, Jack F. Rogan, Adam Dinan, Andrew E. Firth, Byron Andrews, Alexander J. Whitworth, Schraga Schwartz, Alan J. Warren, Michal Minczuk

    Diterbitkan 2022-02-01
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  19. 19
    Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila

    Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila oleh Simonetta Andreazza, Colby L. Samstag, Alvaro Sanchez-Martinez, Erika Fernandez-Vizarra, Aurora Gomez-Duran, Juliette J. Lee, Roberta Tufi, Michael J. Hipp, Elizabeth K. Schmidt, Thomas J. Nicholls, Payam A. Gammage, Patrick F. Chinnery, Michal Minczuk, Leo J. Pallanck, Scott R. Kennedy, Alexander J. Whitworth

    Diterbitkan 2019-07-01
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  20. 20
    SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

    SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis oleh Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo, Guillaume M. Hautbergue

    Diterbitkan 2021-08-01
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