Hasil Pencarian - Alex N. Bullock

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  1. 1
    ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex

    ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex oleh Eleanor Williams, Elise Riesebos, Georgina Kerr, Alex N. Bullock

    Diterbitkan 2021-01-01
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  2. 2
    Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12

    Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12 oleh Zhuoyao Chen, Gregory A. Wasney, Sarah Picaud, Panagis Filippakopoulos, Masoud Vedadi, Vincenzo D'Angiolella, Alex N. Bullock

    Diterbitkan 2020-06-01
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  3. 3
    Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva

    Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva oleh Francesc Ventura, Eleanor Williams, Makoto Ikeya, Alex N. Bullock, Peter ten Dijke, Marie-José Goumans, Gonzalo Sanchez-Duffhues

    Diterbitkan 2021-02-01
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  4. 4
    Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.

    Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor. oleh Alex N Bullock, Santina Russo, Ann Amos, Nicholas Pagano, Howard Bregman, Judit E Debreczeni, Wen Hwa Lee, Frank von Delft, Eric Meggers, Stefan Knapp

    Diterbitkan 2009-10-01
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  5. 5
    CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function

    CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function oleh Peter Canning, Kwangjin Park, João Gonçalves, Chunmei Li, Conor J. Howard, Timothy D. Sharpe, Liam J. Holt, Laurence Pelletier, Alex N. Bullock, Michel R. Leroux

    Diterbitkan 2018-01-01
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  6. 6
    Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients.

    Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients. oleh Kirsten A Petrie, Wen Hwa Lee, Alex N Bullock, Jenny J Pointon, Roger Smith, R Graham G Russell, Matthew A Brown, B Paul Wordsworth, James T Triffitt

    Diterbitkan 2009-01-01
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  7. 7
    Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP)

    Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Sarac... oleh Bernard J. Smilde, Clemens Stockklausner, Richard Keen, Andrew Whittaker, Alex N. Bullock, Annette von Delft, Natasja M. van Schoor, Paul B. Yu, E. Marelise W. Eekhoff

    Diterbitkan 2022-06-01
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  8. 8
    PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo

    PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo oleh Elizabeth J. Brown, Leire Balaguer-Lluna, Adam P. Cribbs, Martin Philpott, Leticia Campo, Molly Browne, Jong Fu Wong, Udo Oppermann, Ángel M. Carcaboso, Alex N. Bullock, Gillian Farnie

    Diterbitkan 2024-01-01
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  9. 9
    A new class of small molecule inhibitor of BMP signaling.

    A new class of small molecule inhibitor of BMP signaling. oleh Caroline E Sanvitale, Georgina Kerr, Apirat Chaikuad, Marie-Christine Ramel, Agustin H Mohedas, Sabine Reichert, You Wang, James T Triffitt, Gregory D Cuny, Paul B Yu, Caroline S Hill, Alex N Bullock

    Diterbitkan 2013-01-01
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  10. 10
    Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family

    Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family oleh Olivier E. Nonga, Darja Lavogina, Erki Enkvist, Katrin Kestav, Apirat Chaikuad, Sarah E. Dixon-Clarke, Alex N. Bullock, Sergei Kopanchuk, Taavi Ivan, Ramesh Ekambaram, Kaido Viht, Stefan Knapp, Asko Uri

    Diterbitkan 2021-07-01
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  11. 11
    Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

    Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1. oleh Edmond M Linossi, Indu R Chandrashekaran, Tatiana B Kolesnik, James M Murphy, Andrew I Webb, Tracy A Willson, Lukasz Kedzierski, Alex N Bullock, Jeffrey J Babon, Raymond S Norton, Nicos A Nicola, Sandra E Nicholson

    Diterbitkan 2013-01-01
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  12. 12
    Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva

    Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva oleh Eleanor Williams, Jana Bagarova, Georgina Kerr, Dong-Dong Xia, Elsie S. Place, Devaveena Dey, Yue Shen, Geoffrey A. Bocobo, Agustin H. Mohedas, Xiuli Huang, Philip E. Sanderson, Arthur Lee, Wei Zheng, Aris N. Economides, James C. Smith, Paul B. Yu, Alex N. Bullock

    Diterbitkan 2021-04-01
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  13. 13
    Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva‐Derived Endothelial Cells

    Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva‐Derived Endothelial Cells oleh Gonzalo Sánchez‐Duffhues, Eleanor Williams, Pascal Benderitter, Valeria Orlova, Michiel vanWijhe, Amaya Garcia de Vinuesa, Georgina Kerr, Josselin Caradec, Kirsten Lodder, Hetty C. deBoer, Marie‐José Goumans, Elisabeth M W Eekhoff, Antonio Morales‐Piga, Javier Bachiller‐Corral, Pieter Koolwijk, Alex N. Bullock, Jan Hoflack, Peter tenDijke

    Diterbitkan 2019-11-01
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  14. 14
    Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

    Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology oleh Anna Castano, Margaux Silvestre, Carrow I Wells, Jennifer L Sanderson, Carla A Ferrer, Han Wee Ong, Yi Lang, William Richardson, Josie A Silvaroli, Frances M Bashore, Jeffery L Smith, Isabelle M Genereux, Kelvin Dempster, David H Drewry, Navlot S Pabla, Alex N Bullock, Tim A Benke, Sila K Ultanir, Alison D Axtman

    Diterbitkan 2023-07-01
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  15. 15
    Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel DiseaseSummary

    Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel DiseaseSummary oleh Ahmad A. Al-Shaibi, Ussama M. Abdel-Motal, Satanay Z. Hubrack, Alex N. Bullock, Amna A. Al-Marri, Nourhen Agrebi, Abdulrahman A. Al-Subaiey, Nazira A. Ibrahim, Adrian K. Charles, Mamoun Elawad, Holm H. Uhlig, Bernice Lo, Saad R. Al-Kaabi, Muneera J. Al-Mohannadi, Fayaz A. Mir, Holm H. Uhlig, Simon P.L. Travis, Mamoun Elawad, Anthony K. Akobeng, Nazira A. Ibrahim, Fatma Al-Mudahka, Bernice Lo

    Diterbitkan 2021-01-01
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