Hasil Pencarian - Adrian M Isaacs

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  1. 1
    Specific biomarkers for C9orf72 FTD/ALS could expedite the journey towards effective therapies

    Specific biomarkers for C9orf72 FTD/ALS could expedite the journey towards effective therapies oleh Rubika Balendra, Thomas G Moens, Adrian M Isaacs

    Diterbitkan 2017-05-01
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  2. 2
    Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity

    Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical... oleh Annelies Quaegebeur, Idoia Glaria, Tammaryn Lashley, Adrian M. Isaacs

    Diterbitkan 2020-11-01
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  3. 3
    Quantitative analysis of cryptic splicing associated with TDP-43 depletion

    Quantitative analysis of cryptic splicing associated with TDP-43 depletion oleh Jack Humphrey, Warren Emmett, Pietro Fratta, Adrian M. Isaacs, Vincent Plagnol

    Diterbitkan 2017-05-01
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  4. 4
    Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain

    Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain oleh Javier Morón-Oset, Tessa Supèr, Jacqueline Esser, Adrian M. Isaacs, Sebastian Grönke, Linda Partridge

    Diterbitkan 2019-12-01
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  5. 5
    Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS

    Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS oleh Lauren M. Gittings, Sandrine C. Foti, Bridget C. Benson, Priya Gami-Patel, Adrian M. Isaacs, Tammaryn Lashley

    Diterbitkan 2019-02-01
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  6. 6
    Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration

    Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration oleh Sarah Mizielinska, Charlotte E. Ridler, Rubika Balendra, Annora Thoeng, Nathan S. Woodling, Friedrich A. Grässer, Vincent Plagnol, Tammaryn Lashley, Linda Partridge, Adrian M. Isaacs

    Diterbitkan 2017-04-01
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  7. 7
    The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease [version 2; referees: 1 approved, 2 approved with reservations]

    The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease [version 2; referees: 1 approved, 2 approved with reservations] oleh Justin L. Tosh, Matthew Rickman, Ellie Rhymes, Frances E. Norona, Emma Clayton, Lennart Mucke, Adrian M. Isaacs, Elizabeth M.C. Fisher, Frances K. Wiseman

    Diterbitkan 2018-10-01
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  8. 8
    The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease [version 1; referees: 1 approved, 2 approved with reservations]

    The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease [version 1; referees: 1 approved, 2 approved with reservations] oleh Justin L. Tosh, Matthew Rickman, Ellie Rhymes, Frances E. Norona, Emma Clayton, Lennart Mucke, Adrian M. Isaacs, Elizabeth M.C. Fisher, Frances K. Wiseman

    Diterbitkan 2017-09-01
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  9. 9
    Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity

    Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity oleh Javier Morón-Oset, Lilly Katharina Sophie Fischer, Nathalie Jauré, Pingze Zhang, Annika Julia Jahn, Tessa Supèr, André Pahl, Adrian M. Isaacs, Sebastian Grönke, Linda Partridge

    Diterbitkan 2023-08-01
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  10. 10
    Opinion: more mouse models and more translation needed for ALS

    Opinion: more mouse models and more translation needed for ALS oleh Elizabeth M.C. Fisher, Linda Greensmith, Andrea Malaspina, Pietro Fratta, Michael G. Hanna, Giampietro Schiavo, Adrian M. Isaacs, Richard W. Orrell, Thomas J. Cunningham, Abraham Acevedo Arozena

    Diterbitkan 2023-05-01
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  11. 11
    A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer's disease models.

    A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer's disease models. oleh Dongwei Xu, Alec Vincent, Andrés González-Gutiérrez, Benjamin Aleyakpo, Sharifah Anoar, Ashling Giblin, Magda L Atilano, Mirjam Adams, Dunxin Shen, Annora Thoeng, Elli Tsintzas, Marie Maeland, Adrian M Isaacs, Jimena Sierralta, Teresa Niccoli

    Diterbitkan 2023-09-01
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  12. 12
    A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer’s disease models

    A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer’s disease models oleh Dongwei Xu, Alec Vincent, Andrés González-Gutiérrez, Benjamin Aleyakpo, Sharifah Anoar, Ashling Giblin, Magda L. Atilano, Mirjam Adams, Dunxin Shen, Annora Thoeng, Elli Tsintzas, Marie Maeland, Adrian M. Isaacs, Jimena Sierralta, Teresa Niccoli

    Diterbitkan 2023-09-01
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  13. 13
    Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila

    Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila oleh Magda L Atilano, Sebastian Grönke, Teresa Niccoli, Liam Kempthorne, Oliver Hahn, Javier Morón-Oset, Oliver Hendrich, Miranda Dyson, Mirjam Lisette Adams, Alexander Hull, Marie-Therese Salcher-Konrad, Amy Monaghan, Magda Bictash, Idoia Glaria, Adrian M Isaacs, Linda Partridge

    Diterbitkan 2021-03-01
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  14. 14
    Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster

    Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster oleh Janani Iyer, Qingyu Wang, Thanh Le, Lucilla Pizzo, Sebastian Grönke, Surendra S. Ambegaokar, Yuzuru Imai, Ashutosh Srivastava, Beatriz Llamusí Troisí, Graeme Mardon, Ruben Artero, George R. Jackson, Adrian M. Isaacs, Linda Partridge, Bingwei Lu, Justin P. Kumar, Santhosh Girirajan

    Diterbitkan 2016-05-01
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  15. 15
    C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

    C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9 oleh Björn F. Vahsen, Sumedha Nalluru, Georgia R. Morgan, Lucy Farrimond, Emily Carroll, Yinyan Xu, Kaitlyn M. L. Cramb, Benazir Amein, Jakub Scaber, Antigoni Katsikoudi, Ana Candalija, Mireia Carcolé, Ruxandra Dafinca, Adrian M. Isaacs, Richard Wade-Martins, Elizabeth Gray, Martin R. Turner, Sally A. Cowley, Kevin Talbot

    Diterbitkan 2023-09-01
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  16. 16
    Dysregulation in Subcellular Localization of Myelin Basic Protein mRNA Does Not Result in Altered Myelination in Amyotrophic Lateral Sclerosis

    Dysregulation in Subcellular Localization of Myelin Basic Protein mRNA Does Not Result in Altered Myelination in Amyotrophic Lateral Sclerosis oleh Samantha K. Barton, Samantha K. Barton, Samantha K. Barton, Samantha K. Barton, Jenna M. Gregory, Jenna M. Gregory, Jenna M. Gregory, Bhuvaneish T. Selvaraj, Bhuvaneish T. Selvaraj, Bhuvaneish T. Selvaraj, Karina McDade, Karina McDade, Christopher M. Henstridge, Christopher M. Henstridge, Christopher M. Henstridge, Tara L. Spires-Jones, Tara L. Spires-Jones, Tara L. Spires-Jones, Owen G. James, Owen G. James, Owen G. James, Arpan R. Mehta, Arpan R. Mehta, Arpan R. Mehta, David Story, David Story, David Story, Karen Burr, Karen Burr, Karen Burr, Dario Magnani, Dario Magnani, Dario Magnani, Adrian M. Isaacs, Adrian M. Isaacs, Colin Smith, Colin Smith, Siddharthan Chandran, Siddharthan Chandran, Siddharthan Chandran

    Diterbitkan 2021-09-01
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  17. 17
    Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids

    Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids oleh Astrid T. van der Geest, Channa E. Jakobs, Tijana Ljubikj, Christiaan F. M. Huffels, Marta Cañizares Luna, Renata Vieira de Sá, Youri Adolfs, Marina de Wit, Daan H. Rutten, Marthe Kaal, Maria M. Zwartkruis, Mireia Carcolé, Ewout J. N. Groen, Elly M. Hol, Onur Basak, Adrian M. Isaacs, Henk-Jan Westeneng, Leonard H. van den Berg, Jan H. Veldink, Domino K. Schlegel, R. Jeroen Pasterkamp

    Diterbitkan 2024-09-01
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  18. 18
    SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

    SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits oleh Guillaume M. Hautbergue, Lydia M. Castelli, Laura Ferraiuolo, Alvaro Sanchez-Martinez, Johnathan Cooper-Knock, Adrian Higginbottom, Ya-Hui Lin, Claudia S. Bauer, Jennifer E. Dodd, Monika A. Myszczynska, Sarah M. Alam, Pierre Garneret, Jayanth S. Chandran, Evangelia Karyka, Matthew J. Stopford, Emma F. Smith, Janine Kirby, Kathrin Meyer, Brian K. Kaspar, Adrian M. Isaacs, Sherif F. El-Khamisy, Kurt J. De Vos, Ke Ning, Mimoun Azzouz, Alexander J. Whitworth, Pamela J. Shaw

    Diterbitkan 2017-07-01
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  19. 19
    G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

    G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo oleh Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert‐Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie‐Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs

    Diterbitkan 2017-11-01
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