Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance
oleh: Kristi J. Warren, Cassandra Deering-Rice, Tom Huecksteadt, Shubhanshi Trivedi, Alessandro Venosa, Christopher Reilly, Karl Sanders, Frederic Clayton, Todd A. Wyatt, Jill A. Poole, Nicola M. Heller, Daniel Leung, Robert Paine
| Format: | Article |
|---|---|
| Diterbitkan: | BMC 2023-01-01 |
Deskripsi
Highlights Steady levels of estrogen are associated with changes in allergic inflammation. When E2 is maintained at a level comparable to the mid-follicular phase of ovulation mucus production and airway hyperreactivity are increased. Estrogen reduces eosinophils and ILC2 following allergen challenges. Neutrophils and CD19+ B cells were unaffected in the lung tissues by estrogen treatment.