Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis
oleh: José Avendaño-Ortiz, Roberto Lozano-Rodríguez, Alejandro Martín-Quirós, Charbel Maroun-Eid, Verónica Terrón, Jaime Valentín, Karla Montalbán-Hernández, Fátima Ruiz de la Bastida, Miguel A. García-Garrido, Carolina Cubillos-Zapata, Álvaro del Balzo-Castillo, Luis A. Aguirre, Eduardo López-Collazo
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2020-12-01 |
Deskripsi
Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, patients with long-term SARS-CoV-2 infection also exhibited a significant blockade of T-cells proliferation.