Somatic mutations render human exome and pathogen DNA more similar. за авторством Ehsan Ebrahimzadeh, Maggie Engler, David Tse, Razvan Cristescu, Aslan Tchamkerten

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Concordance between single-nucleotide polymorphism–based genomic instability assays and a next-generation sequencing–based homologous recombination deficiency test за авторством Razvan Cristescu, Xiao Qiao Liu, Gladys Arreaza, Cai Chen, Andrew Albright, Ping Qiu, Matthew J. Marton

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Prevalence and prognosis of hypoxia‐inducible factor‐2α (HIF‐2α) pathway gene mutations across advanced solid tumors за авторством Wenjun Zhong, Jiemin Ma, Cai Chen, E. J. Dettman, Razvan Cristescu, Girish S. Naik, Fan Jin, Changxia Shao

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80 Evaluation of the trusight oncology 500 assay for routine clinical testing of tumor mutational burden (TMB) and clinical utility for predicting response to pembrolizumab за авторством Lei Chen, Diane Levitan, Gladys Arreaza, Razvan Cristescu, Ping Qiu, Bo Wei, John Kang, Miho Kibukawa, Maureen Maguire, Lixin Lang, Deepti Aurora-Garg

Tumor mutational burden predicts the efficacy of pembrolizumab monotherapy: a pan-tumor retrospective analysis of participants with advanced solid tumors за авторством Lei Xu, Razvan Cristescu, Jared Lunceford, Andrey Loboda, Andrew Albright, Xiao Qiao Liu, Alexandra Snyder, Fan Jin, Lixin Lang, Deepti Aurora-Garg, Eric H Rubin

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Baseline and post-treatment biomarkers of resistance to anti-PD-1 therapy in acral and mucosal melanoma: an observational study за авторством Qing Zhao, Jeeyun Lee, Razvan Cristescu, Xiao Qiao Liu, Jennifer H. Yearley, Seung Tae Kim, Yuan Sun, Irene M. Shui, Tasmiah Choudhury, Andrea L. Webber, Clemens Krepler

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Clinical implication of tumor mutational burden in patients with HER2-positive refractory metastatic breast cancer за авторством Song Ee Park, Kyunghee Park, Eunjin Lee, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Choonghoon Lee, Hun Jung, Soo Youn Cho, Woong-Yang Park, Razvan Cristescu, Yeon Hee Park

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Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination за авторством Slim Fourati, Razvan Cristescu, Andrey Loboda, Aarthi Talla, Ali Filali, Radha Railkar, Andrea K. Schaeffer, David Favre, Dominic Gagnon, Yoav Peretz, I-Ming Wang, Chan R. Beals, Danilo R. Casimiro, Leonidas N. Carayannopoulos, Rafick-Pierre Sékaly

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Evaluation of potential biomarkers for lenvatinib plus pembrolizumab among patients with advanced endometrial cancer: results from Study 111/KEYNOTE-146 за авторством Razvan Cristescu, Andrey Loboda, Robert Orlowski, Vicky Makker, Matthew H Taylor, Carol Aghajanian, Petar Jelinic, Lea Dutta, Allen L Cohn, Marcia S Brose, Christopher Di Simone, Zhu Alexander Cao, Leah Suttner, Junji Matsui, Corina E Dutcus, Yukinori Minoshima, Mark J Messing

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Influence of tumor mutational burden, inflammatory gene expression profile, and PD-L1 expression on response to pembrolizumab in head and neck squamous cell carcinoma за авторством Makoto Tahara, Ranee Mehra, Kei Muro, Bhumsuk Keam, Mark Ayers, Robin Mogg, Razvan Cristescu, Jared Lunceford, Andrew Albright, Jonathan Cheng, Barbara Burtness, Shilpa Gupta, Hyunseok Kang, Laura Q M Chow, Lingkang Huang, Joseph P Eder, Jared Weiss, Robert I Haddad, Tanguy Y Seiwert, Iris Gluck

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Association between gene expression signatures and clinical outcomes of pembrolizumab versus paclitaxel in advanced gastric cancer: exploratory analysis from the randomized, contro... за авторством Kohei Shitara, Kei Muro, Razvan Cristescu, Michael Nebozhyn, Andrey Loboda, Hyun Cheol Chung, Wasat Mansoor, Mustafa Ozguroglu, Mario Mandala, Maria Di Bartolomeo, Christian Caglevic, Julie Kobie, Min-Hee Ryu, Z Alexander Cao, Tomasz Olesinski, Eray Goekkurt, Raymond S McDermott, Zev A Wainberg, Chie-Schin Shih

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457 KEYNOTE-495/KeyImPaCT: interim analysis of a randomized, biomarker-directed, phase 2 trial of pembrolizumab-based combination therapy for non–small cell lung cancer (NSCLC) за авторством Enriqueta Felip, Jianda Yuan, Lawrence Fong, Charu Aggarwal, Razvan Cristescu, Myung-Ju Ahn, Alexandra Snyder, Matthew Hellmann, Roy Herbst, Martin Gutierrez, Edward Garon, Jong-Seok Lee, Julie Kobie, Matthew Gubens, Daniel Shao Weng Tan, Joanne WY Chiu, James Chih-Hsin Yang, Giovanna Finocchiaro, Alexander Luft, Gregory Landers, Andrea Basso, Hua Ma, John Palcza

Biomarkers predictive of response to pembrolizumab in head and neck cancer за авторством David G. Pfister, Robert I. Haddad, Francis P. Worden, Jared Weiss, Ranee Mehra, Laura Q. M. Chow, Stephen V. Liu, Hyunseok Kang, Nabil F. Saba, Lori J. Wirth, Ammar Sukari, Erminia Massarelli, Mark Ayers, Andrew Albright, Andrea L. Webber, Robin Mogg, Jared Lunceford, Lingkang Huang, Razvan Cristescu, Jonathan Cheng, Tanguy Y. Seiwert, Joshua M. Bauml

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Hepatocellular carcinoma patients with high circulating cytotoxic T cells and intra-tumoral immune signature benefit from pembrolizumab: results from a single-arm phase 2 trial за авторством Jung Yong Hong, Hee Jin Cho, Jason K. Sa, Xiaoqiao Liu, Sang Yun Ha, Taehyang Lee, Hajung Kim, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Hee Chul Park, Tae Wook Kang, Hyunchul Rhim, Su Jin Lee, Razvan Cristescu, Jeeyun Lee, Yong Han Paik, Ho Yeong Lim

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364 KRAS mutations in patients with nonsquamous non–small-cell lung cancer: prevalence and relationship with PD-L1 expression, tumor mutation burden and smoking status за авторством Enriqueta Felip, Marina Chiara Garassino, Edward B Garon, Roy S Herbst, Razvan Cristescu, Martin Reck, Yi-Long Wu, Byoung Chul Cho, Michael Boyer, Delvys Rodriguez-Abreu, Hidehito Horinouchi, Rina Hui, Gilberto de Castro, Gilberto Lopes, Dariusz M Kowalski, Hande Z Turna, Tony SK Mok, Shirish M Gadgeel, Kazuo Kasahara, Julie Kobie, Yongjin Li, Mark A Ayers, M Catherine Pietanza

Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity за авторством Yanxia Guo, Kenzie D. MacIsaac, Yi Chen, Richard J. Miller, Renu Jain, Barbara Joyce-Shaikh, Heidi Ferguson, I-Ming Wang, Razvan Cristescu, John Mudgett, Laura Engstrom, Kyle J. Piers, Gretchen A. Baltus, Kenneth Barr, Hongjun Zhang, Huseyin Mehmet, Laxminarayan G. Hegde, Xiao Hu, Laura L. Carter, Thomas D. Aicher, Gary Glick, Dennis Zaller, Abbas Hawwari, Craig C. Correll, Dallas C. Jones, Daniel J. Cua

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Associations of Tissue Tumor Mutational Burden and Mutational Status With Clinical Outcomes With Pembrolizumab Plus Chemotherapy Versus Chemotherapy For Metastatic NSCLC за авторством Marina C. Garassino, MD, Shirish Gadgeel, MD, Silvia Novello, MD, PhD, Balazs Halmos, MD, Enriqueta Felip, MD, Giovanna Speranza, MD, Rina Hui, PhD, Edward B. Garon, MD, Hidehito Horinouchi, MD, PhD, Shunichi Sugawara, MD, PhD, Delvys Rodriguez-Abreu, MD, PhD, Martin Reck, MD, Razvan Cristescu, PhD, Deepti Aurora-Garg, PhD, Andrey Loboda, PhD, Jared Lunceford, PhD, Julie Kobie, PhD, Mark Ayers, MS, Bilal Piperdi, MD, M. Catherine Pietanza, MD, Luis Paz-Ares, MD, PhD

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