Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells. по Patrick E MacDonald, Patrik Rorsman

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SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1. по Jeshmi Jeyabalan, M Andrew Nesbit, Juris Galvanovskis, Richard Callaghan, Patrik Rorsman, Rajesh V Thakker

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The endoplasmic reticulum plays a key role in α-cell intracellular Ca2+ dynamics and glucose-regulated glucagon secretion in mouse islets по Samuel Acreman, Jinfang Ma, Geoffrey Denwood, Rui Gao, Andrei Tarasov, Patrik Rorsman, Quan Zhang

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α-cell glucokinase suppresses glucose-regulated glucagon secretion по Davide Basco, Quan Zhang, Albert Salehi, Andrei Tarasov, Wanda Dolci, Pedro Herrera, Ioannis Spiliotis, Xavier Berney, David Tarussio, Patrik Rorsman, Bernard Thorens

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Defective secretion of islet hormones in chromogranin-B deficient mice. по Stefanie Obermüller, Federico Calegari, Angus King, Anders Lindqvist, Ingmar Lundquist, Albert Salehi, Maura Francolini, Patrizia Rosa, Patrik Rorsman, Wieland B Huttner, Sebastian Barg

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Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue по Marco Bauzá-Thorbrügge, Elin Banke, Belén Chanclón, Eduard Peris, Yanling Wu, Saliha Musovic, Cecilia Jönsson, Peter Strålfors, Patrik Rorsman, Charlotta S. Olofsson, Ingrid Wernstedt Asterholm

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A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. по Patrick E MacDonald, Yang Zhang De Marinis, Reshma Ramracheya, Albert Salehi, Xiaosong Ma, Paul R V Johnson, Roger Cox, Lena Eliasson, Patrik Rorsman

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CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets по Linford J.B. Briant, Michael S. Dodd, Margarita V. Chibalina, Nils J.G. Rorsman, Paul R.V. Johnson, Peter Carmeliet, Patrik Rorsman, Jakob G. Knudsen

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PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery по Reshma D. Ramracheya, Laura J. McCulloch, Anne Clark, David Wiggins, Helene Johannessen, Magnus Kringstad Olsen, Xing Cai, Chun-Mei Zhao, Duan Chen, Patrik Rorsman

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Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet по Joely A. Kellard, Nils J.G. Rorsman, Thomas G. Hill, Sarah L. Armour, Martijn van de Bunt, Patrik Rorsman, Jakob G. Knudsen, Linford J.B. Briant

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RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human β Cells по Vikash Chandra, Olivier Albagli-Curiel, Benoit Hastoy, Julie Piccand, Clotilde Randriamampita, Emmanuel Vaillant, Hélène Cavé, Kanetee Busiah, Philippe Froguel, Martine Vaxillaire, Patrik Rorsman, Michel Polak, Raphael Scharfmann

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A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis по Benoît Hastoy, Pier A. Scotti, Alexandra Milochau, Zahia Fezoua-Boubegtiten, Jorge Rodas, Rémi Megret, Bernard Desbat, Michel Laguerre, Sabine Castano, David Perrais, Patrik Rorsman, Reiko Oda, Jochen Lang

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High-content screening identifies a role for Na+ channels in insulin production по Marta Szabat, Honey Modi, Reshma Ramracheya, Vroni Girbinger, Forson Chan, Jason T. C. Lee, Micah Piske, Sepehr Kamal, Yu Hsuan Carol Yang, Andrea Welling, Patrik Rorsman, James D. Johnson

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A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells по Yingying Ye, Mohammad Barghouth, Haiqiang Dou, Cheng Luan, Yongzhi Wang, Alexandros Karagiannopoulos, Xiaoping Jiang, Ulrika Krus, Malin Fex, Quan Zhang, Lena Eliasson, Patrik Rorsman, Enming Zhang, Erik Renström

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Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome. по Robert H Wallis, Stephan C Collins, Pamela J Kaisaki, Karène Argoud, Steven P Wilder, Karin J Wallace, Massimiliano Ria, Alain Ktorza, Patrik Rorsman, Marie-Thérèse Bihoreau, Dominique Gauguier

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AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity по Caroline M. Gorvin, Angela Rogers, Benoit Hastoy, Andrei I. Tarasov, Morten Frost, Silvia Sposini, Asuka Inoue, Michael P. Whyte, Patrik Rorsman, Aylin C. Hanyaloglu, Gerda E. Breitwieser, Rajesh V. Thakker

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Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells по Elizabeth Haythorne, Matthew Lloyd, John Walsby-Tickle, Andrei I. Tarasov, Jonas Sandbrink, Idoia Portillo, Raul Terron Exposito, Gregor Sachse, Malgorzata Cyranka, Maria Rohm, Patrik Rorsman, James McCullagh, Frances M. Ashcroft

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Hindbrain insulin controls feeding behavior по Kim Eerola, Francesco Longo, Thomas M. Reinbothe, Jennifer E. Richard, Olesya T. Shevchouk, Lorena López-Ferreras, Devesh Mishra, Mohammed Asker, Johan Tolö, Caroline Miranda, Saliha Musovic, Charlotta S. Olofsson, Patrik Rorsman, Karolina P. Skibicka

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Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells по Melissa F. Brereton, Maria Rohm, Kenju Shimomura, Christian Holland, Sharona Tornovsky-Babeay, Daniela Dadon, Michaela Iberl, Margarita V. Chibalina, Sheena Lee, Benjamin Glaser, Yuval Dor, Patrik Rorsman, Anne Clark, Frances M. Ashcroft

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A method for the generation of human stem cell-derived alpha cells по Quinn P. Peterson, Adrian Veres, Lihua Chen, Michael Q. Slama, Jennifer H. R. Kenty, Shaimaa Hassoun, Matthew R. Brown, Haiqiang Dou, Caden D. Duffy, Quan Zhou, Aleksey V. Matveyenko, Björn Tyrberg, Maria Sörhede-Winzell, Patrik Rorsman, Douglas A. Melton

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