Editorial: Preclinical models and emerging technologies to study the effects of the tumor microenvironment on cancer heterogeneity and drug resistance ‌ Giulia Adriani, Giulia Adriani, Paola Cappello, Sara Lovisa, Sara Lovisa

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The Glycolytic Pathway as a Target for Novel Onco-Immunology Therapies in Pancreatic Cancer ‌ Claudia Curcio, Silvia Brugiapaglia, Sara Bulfamante, Laura Follia, Paola Cappello, Francesco Novelli

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IL17A Depletion Affects the Metabolism of Macrophages Treated with Gemcitabine ‌ Cecilia Roux, Gianluca Mucciolo, Joanna Kopecka, Francesco Novelli, Chiara Riganti, Paola Cappello

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Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype ‌ Simone Borgoni, Andrea Iannello, Santina Cutrupi, Paola Allavena, Maurizio D'Incalci, Francesco Novelli, Paola Cappello

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In pancreatic cancer patients, chemotherapy reshapes the gene expression profile and antigen receptor repertoire of T lymphocytes and enhances their effector response to tumor-asso... ‌ Silvia Brugiapaglia, Silvia Brugiapaglia, Sara Bulfamante, Claudia Curcio, Claudia Curcio, Maddalena Arigoni, Raffaele Calogero, Lisa Bonello, Elisa Genuardi, Rosella Spadi, Maria Antonietta Satolli, Donata Campra, Daniele Giordano, Paola Cappello, Paola Cappello, Francesca Cordero, Francesco Novelli, Francesco Novelli

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Diabetes promotes invasive pancreatic cancer by increasing systemic and tumour carbonyl stress in Kras G12D/+ mice ‌ Stefano Menini, Carla Iacobini, Luisa de Latouliere, Isabella Manni, Martina Vitale, Emanuela Pilozzi, Carlo Pesce, Paola Cappello, Francesco Novelli, Giulia Piaggio, Giuseppe Pugliese

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Effects of Steroids and Tocilizumab on the Immune Response Profile of Patients with COVID-19-Associated ARDS Requiring or Not Veno-Venous Extracorporeal Membrane Oxygenation ‌ Vito Fanelli, Giorgia Montrucchio, Gabriele Sales, Umberto Simonetti, Chiara Bonetto, Francesca Rumbolo, Giulio Mengozzi, Rosario Urbino, Costanza Pizzi, Lorenzo Richiardi, Paola Cappello, Luca Brazzi

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Multiplexed Imaging Mass Cytometry Analysis in Preclinical Models of Pancreatic Cancer ‌ Marco Erreni, Maria Rita Fumagalli, Damiano Zanini, Ermes Candiello, Giorgia Tiberi, Raffaella Parente, Raffaella D’Anna, Elena Magrini, Federica Marchesi, Paola Cappello, Andrea Doni

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Strigolactone Analogs Are Promising Antiviral Agents for the Treatment of Human Cytomegalovirus Infection ‌ Matteo Biolatti, Marco Blangetti, Giulia D’Arrigo, Francesca Spyrakis, Paola Cappello, Camilla Albano, Paolo Ravanini, Santo Landolfo, Marco De Andrea, Cristina Prandi, Valentina Dell’Oste

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PI3Kγ inhibition combined with DNA vaccination unleashes a B-cell-dependent antitumor immunity that hampers pancreatic cancer ‌ Claudia Curcio, Gianluca Mucciolo, Cecilia Roux, Silvia Brugiapaglia, Alessandro Scagliotti, Giorgia Guadagnin, Laura Conti, Dario Longo, Demis Grosso, Mauro Giulio Papotti, Emilio Hirsch, Paola Cappello, Judith A. Varner, Francesco Novelli

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Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic... ‌ Paola Cappello, Maurizio Martini, Aldo Scarpa, Stefano Ugel, Francesco De Sanctis, Giampaolo Tortora, Emilio Bria, Vincenzo Corbo, Carmine Carbone, Geny Piro, Antonio Agostini, Pietro Delfino, Vincenzo Nasca, Francesco Spallotta, Claudio Sette

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Soluble stroma‐related biomarkers of pancreatic cancer ‌ Andrea Resovi, Maria Rosa Bani, Luca Porcu, Alessia Anastasia, Lucia Minoli, Paola Allavena, Paola Cappello, Francesco Novelli, Aldo Scarpa, Eugenio Morandi, Anna Falanga, Valter Torri, Giulia Taraboletti, Dorina Belotti, Raffaella Giavazzi

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In pancreatic cancer, chemotherapy increases antitumor responses to tumor-associated antigens and potentiates DNA vaccination ‌ Paola Cappello, Francesco Novelli, Giorgia Mandili, Claudia Curcio, Sara Bulfamante, Laura Follia, Giulio Ferrero, Emanuela Mazza, Moitza Principe, Francesca Cordero, Maria Antonietta Satolli, Rosella Spadi, Andrea Evangelista, Daniele Giordano, Duy Viet

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Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis ‌ Moitza Principe, Simone Borgoni, Mariafrancesca Cascione, Michelle Samuel Chattaragada, Sammy Ferri-Borgogno, Michela Capello, Sara Bulfamante, Jennifer Chapelle, Francesca Di Modugno, Paola Defilippi, Paola Nisticò, Paola Cappello, Chiara Riganti, Stefano Leporatti, Francesco Novelli

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