Perspective: the top 11 priorities to improve trauma outcomes, from system to patient level 由 Michael C. Reade

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Resuscitation Fluid Choices to Preserve the Endothelial Glycocalyx 由 Elissa M. Milford, Michael C. Reade

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Comment: Is off-label medication use in the ICU a problem? 由 Menino O. Cotta, Jason A. Roberts, Michael C. Reade

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Fingolimod does not prevent syndecan-4 shedding from the endothelial glycocalyx in a cultured human umbilical vein endothelial cell model of vascular injury 由 Elissa M. Milford, Lara Meital, Anna Kuballa, Michael C. Reade, Fraser D. Russell

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Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients 由 John P. R. Moore, Yahya Shehabi, Michael C. Reade, Michael Bailey, John F. Fraser, Lauren Murray, Christopher Anstey, Mervyn Singer

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Level of sedation in critically ill adult patients: a protocol for a systematic review with meta-analysis and trial sequential analysis 由 Candice Delcourt, Niklas Nielsen, Anders Aneman, Markus B Skrifvars, Anthony Delaney, Michael C Reade, Johanna Hästbacka, Johan Holgersson, Ameldina Ceric, Teresa May, Manoj Saxena, Janus Jakobsen

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Effect of level of sedation on outcomes in critically ill adult patients: a systematic review of clinical trials with meta-analysis and trial sequential analysisResearch in context 由 Ameldina Ceric, Johan Holgersson, Teresa L. May, Markus B. Skrifvars, Johanna Hästbacka, Manoj Saxena, Anders Aneman, Anthony Delaney, Michael C. Reade, Candice Delcourt, Janus Christian Jakobsen, Niklas Nielsen

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Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial 由 Bronagh Blackwood, Matt P Wise, Kalliopi Kydonaki, Nazir I Lone, Timothy S Walsh, Christopher J Weir, Benedict Creagh-Brown, Michael C Reade, Lydia M Emerson, Leanne M Aitken, Cathrine A McKenzie

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Protocol for a multicentre prehospital randomised controlled trial investigating tranexamic acid in severe trauma: the PATCH-Trauma trial 由 Brian Burns, Stephen Bernard, Ann-Marie Baker, Peter Cameron, Mark Fitzgerald, Andrew Forbes, Paul Young, Colin McArthur, Paul S Myles, Russell Gruen, Russell L Gruen, Dashiell Gantner, Marc Maegele, Lynnette Murray, Tony Trapani, Tony Smith, Michael C Reade, Veronica Pitt, Robert Medcalf, Michael Reade, Huyen Tran, Grant Christey, Zsolt J Balogh, Anthony Trapani, Lynne Murray, Stefan Mazur, Camila Battistuzzo, Andy Swain, Jasmin Board, Nicole S Ng, Sally Hurford

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