The Innate Immune Playbook for Restricting West Nile Virus Infection por Kendra M. Quicke, Mehul S. Suthar

Obter o texto integral

Innate immune sensing of flaviviruses. por Mehul S Suthar, Sebastian Aguirre, Ana Fernandez-Sesma

Obter o texto integral

Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7. por Stephane Daffis, Mehul S Suthar, Kristy J Szretter, Michael Gale, Michael S Diamond

Obter o texto integral

Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling. por Elizabeth J Faul, Celestine N Wanjalla, Mehul S Suthar, Michael Gale, Christoph Wirblich, Matthias J Schnell

Obter o texto integral

Atovaquone and Pibrentasvir Inhibit the SARS-CoV-2 Endoribonuclease and Restrict Infection In Vitro but Not In Vivo por Troy von Beck, Luis Mena Hernandez, Hongyi Zhou, Katharine Floyd, Mehul S. Suthar, Jeffrey Skolnick, Joshy Jacob

Obter o texto integral

Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection. por James D Brien, Stephane Daffis, Helen M Lazear, Hyelim Cho, Mehul S Suthar, Michael Gale, Michael S Diamond

Obter o texto integral

Dendritic cell-associated MAVS is required to control West Nile virus replication and ensuing humoral immune responses. por Kelsey Roe, Daniela Giordano, Lucy B Young, Kevin E Draves, Ursula Holder, Mehul S Suthar, Michael Gale, Edward A Clark

Obter o texto integral

Timing of exposure is critical in a highly sensitive model of SARS-CoV-2 transmission. por Ketaki Ganti, Lucas M Ferreri, Chung-Young Lee, Camden R Bair, Gabrielle K Delima, Kate E Holmes, Mehul S Suthar, Anice C Lowen

Obter o texto integral

Acetaminophen Intoxication Rapidly Induces Apoptosis of Intestinal Crypt Stem Cells and Enhances Intestinal Permeability por Daniel M. Chopyk, Johnasha D. Stuart, Matthew G. Zimmerman, Jing Wen, Sanjeev Gumber, Mehul S. Suthar, Manoj Thapa, Mark J. Czaja, Arash Grakoui

Obter o texto integral

Pre-Existing Dengue Immunity Drives a DENV-Biased Plasmablast Response in ZIKV-Infected Patient por Siddhartha K. Bhaumik, Lalita Priyamvada, Robert C. Kauffman, Lilin Lai, Muktha S. Natrajan, Alice Cho, Nadine Rouphael, Mehul S. Suthar, Mark J. Mulligan, Jens Wrammert

Obter o texto integral

A systems biology approach reveals that tissue tropism to West Nile virus is regulated by antiviral genes and innate immune cellular processes. por Mehul S Suthar, Margaret M Brassil, Gabriele Blahnik, Aimee McMillan, Hilario J Ramos, Sean C Proll, Sarah E Belisle, Michael G Katze, Michael Gale

Obter o texto integral

Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection. por Stacey A Lapp, Venkata Viswanadh Edara, Austin Lu, Lilin Lai, Laila Hussaini, Ann Chahroudi, Larry J Anderson, Mehul S Suthar, Evan J Anderson, Christina A Rostad

Obter o texto integral

Genetic Diversity in the Collaborative Cross Model Recapitulates Human West Nile Virus Disease Outcomes por Jessica B. Graham, Sunil Thomas, Jessica Swarts, Aimee A. McMillan, Martin T. Ferris, Mehul S. Suthar, Piper M. Treuting, Renee Ireton, Michael Gale, Jennifer M. Lund

Obter o texto integral

Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation por Nicholas K. Hurlburt, Emilie Seydoux, Yu-Hsin Wan, Venkata Viswanadh Edara, Andrew B. Stuart, Junli Feng, Mehul S. Suthar, Andrew T. McGuire, Leonidas Stamatatos, Marie Pancera

Obter o texto integral

Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells. por James R Bowen, Kendra M Quicke, Mohan S Maddur, Justin T O'Neal, Circe E McDonald, Nadia B Fedorova, Vinita Puri, Reed S Shabman, Bali Pulendran, Mehul S Suthar

Obter o texto integral

Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis. por Amelia K Pinto, Hilario J Ramos, Xiaobo Wu, Shilpa Aggarwal, Bimmi Shrestha, Matthew Gorman, Kristin Y Kim, Mehul S Suthar, John P Atkinson, Michael Gale, Michael S Diamond

Obter o texto integral

IL-1β signaling promotes CNS-intrinsic immune control of West Nile virus infection. por Hilario J Ramos, Marion C Lanteri, Gabriele Blahnik, Amina Negash, Mehul S Suthar, Margaret M Brassil, Khushbu Sodhi, Piper M Treuting, Michael P Busch, Philip J Norris, Michael Gale

Obter o texto integral

IPS-1 is essential for the control of West Nile virus infection and immunity. por Mehul S Suthar, Daphne Y Ma, Sunil Thomas, Jennifer M Lund, Nu Zhang, Stephane Daffis, Alexander Y Rudensky, Michael J Bevan, Edward A Clark, Murali-Krishna Kaja, Michael S Diamond, Michael Gale

Obter o texto integral

The amphibian peptide Yodha is virucidal for Zika and dengue viruses por Song Hee Lee, Eui Ho Kim, Justin T. O’neal, Gordon Dale, David J. Holthausen, James R. Bowen, Kendra M. Quicke, Ioanna Skountzou, Shyla Gopal, Sanil George, Jens Wrammert, Mehul S. Suthar, Joshy Jacob

Obter o texto integral

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity por Lizhou Zhang, Cody B. Jackson, Huihui Mou, Amrita Ojha, Haiyong Peng, Brian D. Quinlan, Erumbi S. Rangarajan, Andi Pan, Abigail Vanderheiden, Mehul S. Suthar, Wenhui Li, Tina Izard, Christoph Rader, Michael Farzan, Hyeryun Choe

Obter o texto integral