Spastin MIT Domain Disease-Associated Mutations Disrupt Lysosomal Function door Rachel Allison, James R. Edgar, Evan Reid

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Tetherin is an exosomal tether door James R Edgar, Paul T Manna, Shinichi Nishimura, George Banting, Margaret S Robinson

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The WDR11 complex facilitates the tethering of AP-1-derived vesicles door Paloma Navarro Negredo, James R. Edgar, Paul T. Manna, Robin Antrobus, Margaret S. Robinson

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Exploiting Connections for Viral Replication door Louise H. Wong, James R. Edgar, Andrea Martello, Brian J. Ferguson, Emily R. Eden

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A dysfunctional endolysosomal pathway common to two sub-types of demyelinating Charcot–Marie–Tooth disease door James R. Edgar, Anita K. Ho, Matilde Laurá, Rita Horvath, Mary M. Reilly, J. Paul Luzio, Rhys C. Roberts

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AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A door Alexandra K. Davies, Daniel N. Itzhak, James R. Edgar, Tara L. Archuleta, Jennifer Hirst, Lauren P. Jackson, Margaret S. Robinson, Georg H. H. Borner

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Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium door Andreia L. Pinto, Ranjit K. Rai, Jonathan C. Brown, Paul Griffin, James R. Edgar, Anand Shah, Aran Singanayagam, Claire Hogg, Wendy S. Barclay, Clare E. Futter, Thomas Burgoyne

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The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell–cell adhesion door Gareth W Fearnley, Katherine A Young, James R Edgar, Robin Antrobus, Iain M Hay, Wei-Ching Liang, Nadia Martinez-Martin, WeiYu Lin, Janet E Deane, Hayley J Sharpe

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Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health door James L. Daly, Chris M. Danson, Philip A. Lewis, Lu Zhao, Sara Riccardo, Lucio Di Filippo, Davide Cacchiarelli, Daehoon Lee, Stephen J. Cross, Kate J. Heesom, Wen-Cheng Xiong, Andrea Ballabio, James R. Edgar, Peter J. Cullen

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Bioengineered small extracellular vesicles deliver multiple SARS‐CoV‐2 antigenic fragments and drive a broad immunological response door Hannah K. Jackson, Heather M. Long, Juan Carlos Yam‐Puc, Roberta Palmulli, Tracey A. Haigh, Pehuén Pereyra Gerber, Jin S. Lee, Nicholas J. Matheson, Lesley Young, John Trowsdale, Mathew Lo, Graham S. Taylor, James E. Thaventhiran, James R. Edgar

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The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity door Hazel Stewart, Yongxu Lu, Sarah O’Keefe, Anusha Valpadashi, Luis Daniel Cruz-Zaragoza, Hendrik A. Michel, Samantha K. Nguyen, George W. Carnell, Nina Lukhovitskaya, Rachel Milligan, Yasmin Adewusi, Irwin Jungreis, Valeria Lulla, David A. Matthews, Stephen High, Peter Rehling, Edward Emmott, Jonathan L. Heeney, Andrew D. Davidson, James R. Edgar, Geoffrey L. Smith, Andrew E. Firth

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Establishing SARS-CoV-2 membrane protein-specific antibodies as a valuable serological target via high-content microscopy door Daniel M. Williams, Hailey R. Hornsby, Ola M. Shehata, Rebecca Brown, Marta Gallis, Naomi Meardon, Thomas A.H. Newman, Megan Plowright, Domen Zafred, Amber S.M. Shun-Shion, Anthony J. Hodder, Deepa Bliss, Andrew Metcalfe, James R. Edgar, David E. Gordon, Jon R. Sayers, Martin J. Nicklin, Miles Carroll, Paul J. Collini, Stephen Brown, Thushan I. de Silva, Andrew A. Peden

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Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections door Matthew D. Parker, Hazel Stewart, Ola M. Shehata, Benjamin B. Lindsey, Dhruv R. Shah, Sharon Hsu, Alexander J. Keeley, David G. Partridge, Shay Leary, Alison Cope, Amy State, Katie Johnson, Nasar Ali, Rasha Raghei, Joe Heffer, Nikki Smith, Peijun Zhang, Marta Gallis, Stavroula F. Louka, Hailey R. Hornsby, Hatoon Alamri, Max Whiteley, Benjamin H. Foulkes, Stella Christou, Paige Wolverson, Manoj Pohare, Samantha E. Hansford, Luke R. Green, Cariad Evans, Mohammad Raza, Dennis Wang, Andrew E. Firth, James R. Edgar, Silvana Gaudieri, Simon Mallal, The COVID-19 Genomics UK (COG-UK) consortium, Mark O. Collins, Andrew A. Peden, Thushan I. de Silva

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