Conducting non-commercial international clinical trials: the ICR-CTSU experience von Lisa Fox, Christy Toms, Sarah Kernaghan, Claire Snowdon, Judith M. Bliss

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"You have to keep your nerve on a DMC." Challenges for Data Monitoring Committees in neonatal intensive care trials: Qualitative accounts from the BRACELET Study. von Claire Snowdon, Peter Brocklehurst, Robert C Tasker, Martin Ward Platt, Diana Elbourne

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Death, bereavement and randomised controlled trials (BRACELET): a methodological study of policy and practice in neonatal and paediatric intensive care trials von Claire Snowdon, Peter Brocklehurst, Robert Tasker, Martin Ward Platt, Sheila Harvey, Diana Elbourne

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The SHOW RESPECT adaptable framework of considerations for planning how to share trial results with participants, based on qualitative findings from trial participants and site sta... von Annabelle South, Claire Snowdon, Eva Burnett, Barbara E. Bierer, Katie Gillies, Talia Isaacs, Matthew R. Sydes

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Adapting Patient and Public Involvement processes in response to the Covid‐19 pandemic von Claire Snowdon, Elizabeth Silver, Paul Charlton, Brian Devlin, Emma Greenwood, Andrew Hutchings, Susan Moug, Ravinder Vohra, Richard Grieve

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Patient and public involvement prior to trial initiation: lessons learnt for rapid partnership in the COVID-19 era von Zahra Jamal, Alexander Perkins, Christopher Allen, Research Advisory Group, Richard Evans, Joanna Sturgess, Claire Snowdon, Tim Clayton, Diana Elbourne

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What parents of children who have received emergency care think about deferring consent in randomised trials of emergency treatments: postal survey. von Carrol Gamble, Simon Nadel, Dee Snape, Andrew McKay, Helen Hickey, Paula Williamson, Linda Glennie, Claire Snowdon, Bridget Young

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Using a theory-informed approach to explore patient and staff perspectives on factors that influence clinical trial recruitment for patients with cirrhosis and small oesophageal va... von Clair Le Boutillier, Claire Snowdon, Vishal Patel, Mark McPhail, Christopher Ward, Ben Carter, Ruhama Uddin, Ane Zamalloa, Vanessa Lawrence

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Operational complexity versus design efficiency: challenges of implementing a phase IIa multiple parallel cohort targeted treatment platform trial in advanced breast cancer von Claire Snowdon, Sarah Kernaghan, Laura Moretti, Nicholas C. Turner, Alistair Ring, Katie Wilkinson, Sue Martin, Stephanie Foster, Lucy S. Kilburn, Judith M. Bliss

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Testing approaches to sharing trial results with participants: The Show RESPECT cluster randomised, factorial, mixed methods trial. von Annabelle South, Nalinie Joharatnam-Hogan, Cara Purvis, Elizabeth C James, Carlos Diaz-Montana, William J Cragg, Conor Tweed, Archie Macnair, Matthew R Sydes, Claire Snowdon, Katie Gillies, Talia Isaacs, Barbara E Bierer, Andrew J Copas

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Clinical effectiveness and cost-effectiveness of emergency surgery for adult emergency hospital admissions with common acute gastrointestinal conditions: the ESORT study von Richard Grieve, Andrew Hutchings, Silvia Moler Zapata, Stephen O’Neill, David G Lugo-Palacios, Richard Silverwood, David Cromwell, Tommaso Kircheis, Elizabeth Silver, Claire Snowdon, Paul Charlton, Geoff Bellingan, Ramani Moonesinghe, Luke Keele, Neil Smart, Robert Hinchliffe

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How surgical Trainee Research Collaboratives achieve success: a mixed methods study to develop trainee engagement strategies von Graeme Maclennan, Nick Heywood, Clare Clement, Natalie S Blencowe, Jane Blazeby, Dmitri Nepogodiev, Laura Magill, Alejandro Arenas-Pinto, Tom Pinkney, J Athene Lane, James Glasbey, Victoria Hardy, Karen Coulman, Jonathan Alistair Cook, Claire Snowdon, Richard Bulbulia, Zoe Hilton

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Practical guidance for planning resources required to support publicly-funded adaptive clinical trials von James M. S. Wason, Munyaradzi Dimairo, Katie Biggs, Sarah Bowden, Julia Brown, Laura Flight, Jamie Hall, Thomas Jaki, Rachel Lowe, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar, Christopher J. Weir, Nina Wilson, Christina Yap, Helen Hancock, Rebecca Maier

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Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project von Nina Wilson, Katie Biggs, Sarah Bowden, Julia Brown, Munyaradzi Dimairo, Laura Flight, Jamie Hall, Anna Hockaday, Thomas Jaki, Rachel Lowe, Caroline Murphy, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar, Christopher J. Weir, Jessica Welburn, Christina Yap, Rebecca Maier, Helen Hancock, James M. S. Wason

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A clinical and economic evaluation of Control of Hyperglycaemia in Paediatric intensive care (CHiP): a randomised controlled trial von Duncan Macrae, Richard Grieve, Elizabeth Allen, Zia Sadique, Helen Betts, Kevin Morris, Vithayathil John Pappachan, Roger Parslow, Robert C Tasker, Paul Baines, Michael Broadhead, Mark L Duthie, Peter-Marc Fortune, David Inwald, Paddy McMaster, Mark J Peters, Margrid Schindler, Carla Guerriero, Deborah Piercy, Zdenek Slavik, Claire Snowdon, Laura Van Dyck, Diana Elbourne

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Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units von Sharon B. Love, Fay Cafferty, Claire Snowdon, Karen Carty, Joshua Savage, Philip Pallmann, Lucy McParland, Louise Brown, Lindsey Masters, Francesca Schiavone, Dominic Hague, Stephen Townsend, Claire Amos, Annabelle South, Kate Sturgeon, Ruth Langley, Timothy Maughan, Nicholas James, Emma Hall, Sarah Kernaghan, Judith Bliss, Nick Turner, Andrew Tutt, Christina Yap, Charlotte Firth, Anthony Kong, Hisham Mehanna, Colin Watts, Robert Hills, Ian Thomas, Mhairi Copland, Sue Bell, David Sebag-Montefiore, Robert Jones, Mahesh K. B. Parmar, Matthew R. Sydes

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Realising the full potential of data-enabled trials in the UK: a call for action von Catherine Hewitt, Ian Roberts, Michael King, Irwin Nazareth, Alan Watkins, Frank Sullivan, Derek Stewart, Nick Freemantle, Jane Daniels, Tobias Dreischulte, Brooke Jackson, Michael Donnelly, Martin Landray, Martin Gulliford, David A Harrison, Adam Streeter, Jennifer Logue, Paula Williamson, Marion Campbell, Martin C Gulliford, Jamie Soames, Dheeraj Rai, Stephanie MacNeill, Marion Bennie, Jo Rycroft-Malone, Matthew R Sydes, Andrew Farmer, Martyn Lewis, Elizabeth Williamson, Xavier Griffin, Colin McCowan, John Wilding, Jennifer Quint, Agnieszka Michael, Murali Shyamsundar, Tom Denwood, Deborah Ashby, Jacqui Nuttall, Kate Williams, Doreen Tembo, David Harrison, Andrew Morris, Fiona Lobban, Claire Snowdon, Martin Gibson, Rhoswyn Walker, Will Whiteley, Nick Mills, Juliet Tizzard, Emer Brady, Guillermo Lopez Campos, Catrin Tudur Smith, Yolanda Barbachano, Steph Garfield-Birkbeck, Will Navaie, Martin O'Kane, Jonathan Sheffield, Paula Walker, Rhoswyn R Walker, Janet Valentine, Susan Beatty, Helen Bodmer, Paul Brocklehurst, Steph Garfield‑Birkbeck, Doug Gould, Thomas Hiemstra, Anna Higgins, Julia Hippisley‑Cox, Sasha Korniak, Marion Mafham, Kathleen Meeley, Chris Newby, Martin O’Kane, Mike Robling, Jo Rycroft‑Malone, Matthew Sydes, Hwyel Williams

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